A5041123083- Parkinson's Disease Mechanisms and Treatments
- Cardiovascular Syncope and Autonomic Disorders
- Heart Rate Variability and Autonomic Control
- Neurological disorders and treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Sleep and Wakefulness Research
- Neuroscience of respiration and sleep
- Restless Legs Syndrome Research
- Obstructive Sleep Apnea Research
- Circadian rhythm and melatonin
- Genetic Neurodegenerative Diseases
- Non-Invasive Vital Sign Monitoring
- RNA regulation and disease
- Migraine and Headache Studies
- EEG and Brain-Computer Interfaces
- Peptidase Inhibition and Analysis
- Transcranial Magnetic Stimulation Studies
- Long-Term Effects of COVID-19
- Mitochondrial Function and Pathology
- Botulinum Toxin and Related Neurological Disorders
- Sarcoidosis and Beryllium Toxicity Research
- Blood Pressure and Hypertension Studies
- Nuclear Structure and Function
- Psychosomatic Disorders and Their Treatments
- Attention Deficit Hyperactivity Disorder
Istituto delle Scienze Neurologiche di Bologna
2011-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2025
Ospedale Bellaria
2020-2025
Institute of Neurological Sciences
2013-2023
University of Bologna
2010-2022
Azienda Unita' Sanitaria Locale Di Modena
2014-2020
University of Cambridge
2020
John Wiley & Sons (United States)
2019
Humanitas University
2019
Hudson Institute
2019
Hereditary amyloid transthyretin amyloidosis with polyneuropathy (ATTRv-PN) is a rare, inherited, multisystemic, progressive adult-onset disease, affecting sensorimotor nerves, and various organs. It caused by mutations in the TTR gene, leading to misfolded monomers that aggregate, forming fibrils. Patisiran small, double-stranded interfering RNA encapsulated lipid nanoparticle, designed enter hepatocytes selectively target mRNA reduce both variant wild-type (wt). This study presents...
<h3>Objective:</h3> To evaluate the predictive value of stridor and its latency onset to investigate role treatment in a cohort patients with multiple system atrophy (MSA) referred tertiary center. <h3>Methods:</h3> We retrospectively identified diagnosed MSA our department beginning 1991 evaluated at least yearly during disease course. Stridor was defined as present when confirmed by whole night video-polysomnography early if presenting within 3 years onset. Survival data, from time death,...
To investigate the impact of coronavirus-disease-2019 (COVID-19) pandemic on European clinical autonomic practice.Eighty-four neurology-driven or interdisciplinary centers in 22 countries were invited to fill a web-based survey between September and November 2021.Forty-six completed (55%). During first year, number performed tilt-table tests, outpatient inpatient visits decreased respectively by 50%, 45% 53%, every-third center reported major adverse events due postponed examinations visits....
Abstract Aims Hereditary transthyretin amyloidosis (ATTRv) is one of the leading aetiologies systemic with more than 135 mutations described and a broad spectrum clinical manifestations. We aimed to provide systematic description population individuals carrying pathogenic (TTR) gene investigate major events during follow-up. Methods results This was an observational, retrospective, cohort study including consecutive patients TTR gene, admitted tertiary referral centre in Bologna, Italy,...
To investigate (1) the prevalence of REM sleep behavior disorder (RBD) as mode disease onset in a cohort patients with multiple system atrophy (MSA) and (2) progression prognosis MSA RBD predating (pre-RBD) following (post-RBD) onset.We retrospectively identified all clinical diagnosis evaluated at least once year during course. Type was defined by first reported motor or autonomic symptom/sign related to MSA. The occurrence symptoms/signs milestone progression, their latency from onset,...
An expert committee was formed to reach consensus on the use of Tilt Table Testing (TTT) in diagnosis disorders that may cause transient loss consciousness (TLOC) and outline when other provocative cardiovascular autonomic tests are needed. While TTT adds history taking, it cannot be a substitute for it. abnormal result is most meaningful if provoked event recognised by patients or eyewitnesses as similar spontaneous ones. The minimum requirements perform tilt table, continuous beat-to-beat...
Levodopa (LD) is the main treatment for parkinsonism, but its use may be limited by a potential hypotensive effect.
Abstract Background Early stridor onset (≤ 3 years from disease onset) is a predictor of shorter survival in Multiple System Atrophy (MSA), but its role on progression not yet established. In MSA, previous studies trajectories did include and REM sleep behavior disorder (RBD) as clinical variable. The aims the study were: (1) to investigate MSA patients with early and/or RBD onset; (2) assess cerebrospinal fluid (CSF) levels neurofilament light chain protein (NfL) disorders. Methods This...
Isolated REM sleep behavior disorder (iRBD) is a prodromal state of α-synucleinopathies, presenting years before overt neurodegenerative disorders. Autonomic nervous system (ANS) involvement, particularly cardiovascular autonomic failure, may indicate progression. However, its role as (multidimensional) marker for disease progression and phenoconversion remains unclear. This study aimed to investigate whether failure symptoms dysfunction serve multidimensional markers in patients with iRBD....
ABSTRACT Background Urinary and sexual symptoms are common following neurological disease, we aimed to develop multidisciplinary inter‐society evidence‐based management guidelines. Methods The ADAPTE framework was used, a systematic search of guidelines published in different languages performed. Guidelines, consensus statements, reviews were included, guideline quality appraised using AGREE II. Patient representatives reviewed the relevance suitability recommendations. A modified Delphi...
The objective of this study was to determine the cardiovascular effects chronic stimulation posterior hypothalamic area (PHA) in cluster headache (CH) patients. Systolic and diastolic blood pressure (SBP, DBP), cardiac output, total peripheral resistance (TPR), heart rate (HR) breathing were monitored at supine rest during head-up tilt test (HUTT), Valsalva manoeuvre, deep breathing, cold face isometric handgrip eight drug-resistant CH patients who underwent monolateral electrode...
Sleep disturbances represent important predictors of poor quality life (QoL) in Parkinson's disease (PD). This open-label pilot study aimed to objectively assess, by means actigraphic recording, effect rotigotine on sleep PD patients with self-reported complaints. 15 underwent one-week recording before (T0) and during (T1) treatment, which was titrated the dose subjectively improving motor symptoms (4-8 mg/24 h). disturbances, daytime sleepiness, cognitive performance, QoL, depression were...
<h3>Objective</h3> To retrospectively describe clinical and instrumental features of a cohort patients with at least 5-year history idiopathic autonomic failure (IAF) longitudinally evaluated the Autonomic Unit University Bologna (IAF-Bo cohort). <h3>Methods</h3> We identified IAF who were referred to our department from 1989 2016 once year during disease course. Clinical data collected medical records. variables categorized as early if presenting within 3 years onset. Predictors associated...
Abstract Advanced age represents one of the major risk factors for Parkinson’s Disease. Recent biomedical studies posit a role microRNAs, also known to be remodelled during ageing. However, relationship between microRNA remodelling and ageing in Disease, has not been fully elucidated. Therefore, aim present study is unravel relevance microRNAs as biomarkers Disease within framework. We employed Next Generation Sequencing profile serum from samples informative (recently diagnosed, drug-naïve)...
Abstract: Hereditary transthyretin amyloidosis (ATTRv) is a multisystemic, rare, inherited, progressive and adult-onset disease, affecting the sensorimotor nerves, heart, autonomic function other organs. The actual scenario of pharmaceutical approaches for ATTRv includes five main groups: TTR stabilizers, mRNA silencers, fibril disruptors, inhibitor seeding gene therapy. Patisiran small, double-stranded interfering RNA encapsulated in lipid nanoparticle, able to penetrate into hepatocytes,...
Of 41 HIV-infected patients with facial lipoatrophy who underwent autologous fat transplantation, disfiguring lipohypertrophy at the graft site occurred same time as recurrent accumulation tissue harvest in 4 had transferred from dorsocervical pad or subcutaneous abdominal tissue.
Abstract Parkinson’s disease (PD) is the neurological disorder showing greatest rise in prevalence from 1990 to 2016. Despite clinical definition criteria and a tremendous effort develop objective biomarkers, precise diagnosis of PD still unavailable at early stage. In recent years, an increasing number studies have used omic methods unveil molecular basis PD, providing detailed characterization potentially pathological alterations various biological specimens. Metabolomics could provide...