A5055926856- Carbohydrate Chemistry and Synthesis
- Chemical Synthesis and Reactions
- Chemical Synthesis and Analysis
- Sulfur-Based Synthesis Techniques
- Organic Chemistry Cycloaddition Reactions
- Asymmetric Synthesis and Catalysis
- Synthesis and Catalytic Reactions
- Synthesis and Reactivity of Sulfur-Containing Compounds
- DNA and Nucleic Acid Chemistry
- Fluorine in Organic Chemistry
- Synthesis of heterocyclic compounds
- HIV/AIDS drug development and treatment
- Phenothiazines and Benzothiazines Synthesis and Activities
- Chemical Reaction Mechanisms
- Oxidative Organic Chemistry Reactions
- Asymmetric Hydrogenation and Catalysis
- Organic and Inorganic Chemical Reactions
- Glycosylation and Glycoproteins Research
- Synthetic Organic Chemistry Methods
- RNA and protein synthesis mechanisms
- Advanced biosensing and bioanalysis techniques
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Nuts composition and effects
- Plant biochemistry and biosynthesis
- Axial and Atropisomeric Chirality Synthesis
University of Naples Federico II
2013-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2024
Federico II University Hospital
1995-2022
Istituto Nazionale di Fisica Nucleare, Sezione di Napoli
1991-2015
University of Rome Tor Vergata
1999
University of Milan
1994
University of Parma
1992
Sapienza University of Rome
1987
Hereditary transthyretin amyloidosis with polyneuropathy (ATTRv) is an adult-onset multisystemic disease, affecting the peripheral nerves, heart, gastrointestinal tract, eyes, and kidneys. Nowadays, several treatment options are available; thus, avoiding misdiagnosis crucial to starting therapy in early disease stages. However, clinical diagnosis may be difficult, as present unspecific symptoms signs. We hypothesize that diagnostic process benefit from use of machine learning (ML).397...
Hereditary amyloid transthyretin amyloidosis with polyneuropathy (ATTRv-PN) is a rare, inherited, multisystemic, progressive adult-onset disease, affecting sensorimotor nerves, and various organs. It caused by mutations in the TTR gene, leading to misfolded monomers that aggregate, forming fibrils. Patisiran small, double-stranded interfering RNA encapsulated lipid nanoparticle, designed enter hepatocytes selectively target mRNA reduce both variant wild-type (wt). This study presents...
Last years have witnessed enormous progresses in glycomic field, mainly as a consequence of the crucial role carbohydrates shown biological systems. While up to few ago attention was focused on use easily available D-sugars, recent interest has emerged around their L-enantiomers, they been found be key components several bioactive compounds, whether form oligosaccharides, glycopeptides, terpene glycosides or other clinically useful agents. However, L-sugars (L-hexoses especially) are rather...
The development of tumor-targeting drug delivery systems, able to selectively transport cytotoxic agents into the tumor site by exploiting subtle morphological and physiological differences between healthy malignant cells, currently stands as one most attractive anticancer strategies used overcome selectivity problems conventional chemotherapy. Owing frequent overexpression folate receptors (FRs) on surface conjugation folic acid (FA) via suitable linkers have demonstrated enhance selective...
The highly stereocontrolled de novo synthesis of l-NBDNJ (the unnatural enantiomer the iminosugar drug Miglustat) and a preliminary evaluation its chaperoning potential are herein reported. is able to enhance lysosomal α-glucosidase levels in Pompe disease fibroblasts, either when administered singularly or coincubated with recombinant human α-glucosidase. In addition, differently from d-enantiomer, does not act as glycosidase inhibitor.
The combined use of silanes (Et3SiH or PMHS) and I2 as novel N-glycosidation reagents for the synthesis bioactive oxathiolane nucleosides 3TC FTC is reported. Both systems (working anhydrous HI sources) were devised to act substrate activators promoters. Excellent results in terms chemical efficiency stereoselectivity reactions obtained; surprisingly, nature protective group at N4 position (fluoro)cytosine additionally influenced stereochemical reaction outcome.
A stereoselective procedure for the preparation of non-naturally occurring deoxy iminosugars belonging to L-series has been developed. The synthesis involves construction key intermediate bicycle pyperidine 8, available in few steps by coupling heterocyclic synthon 3 and readily Garner aldehyde 4.
An efficient and general de novo synthetic route to enantiomerically pure L-hexoses has been accomplished starting from the heterocyclic homologating agent 5,6-dihydro-1,4-dithiin-2-yl[(4-methoxybenzyl)oxy]methane methyl alpha,beta-isopropylidene-L-glycerate. The sugar scaffold was constructed by an acid-catalyzed domino reaction, which enabled selective preparation of either 2,3-dideoxy-alpha-L-threo-hex-2-enopyranosides or 1,6-anhydro-2,3-dideoxy-beta-L-threo-hex-2-enopyranose as key...
Polystyryldiphenylphosphine-halogen complexes are convenient reagents for converting epoxides to halohydrins under mild and non-acidic conditions. The method requires only a filtration evaporation process product isolation.
Oligonucleotides composed of 1',5'-anhydro-arabino-hexitol nucleosides belonging to the L series (L-HNA) were prepared and preliminarily studied as a novel potential base-pairing system. Synthesis enantiopure L-hexitol nucleotide monomers equipped with 2'-(N(6)-benzoyladenin-9-yl) or 2'-(thymin-1-yl) moiety was carried out by de novo approach based on domino reaction key step. The oligonucleotide analogues evaluated in duplex formation natural complements well unnatural sugar-modified...
ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTA New and Versatile Allylic Alcohol Anion Acyl β-Anion Equivalent for Three-Carbon HomologationsRomualdo Caputo, Annalisa Guaragna, Giovanni Palumbo, Silvana PedatellaView Author Information Dipartimento di Chimica Organica e Biologica, Università Napoli Federico II, Via Mezzocannone, 16 I-80134 Napoli, Italy Cite this: J. Org. Chem. 1997, 62, 26, 9369–9371Publication Date (Web):December 1997Publication History Received5 August 1997Published online26...
A novel route to 2',3'-dideoxy-β-l-erythro-hexopyranosyl nucleosides equipped with a 1'-(N(6)-benzoyladenin-9-yl) or 1'-(thymin-1-yl) moiety has been developed. Synthesis of the enantiopure sugar was carried out by de novo approach based on domino reaction as key step. N-Glycosidation explored via either nucleobase-transfer mechanism (B = T) in situ anomerization T), affording target high overall stereoselectivity.