A5081758371- Pain Mechanisms and Treatments
- Heart Rate Variability and Autonomic Control
- Pain Management and Treatment
- Musculoskeletal pain and rehabilitation
- Cardiovascular Syncope and Autonomic Disorders
- Botulinum Toxin and Related Neurological Disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Parkinson's Disease Mechanisms and Treatments
- Myofascial pain diagnosis and treatment
- Laser Applications in Dentistry and Medicine
- Psychosomatic Disorders and Their Treatments
- Neurological disorders and treatments
- Pain Management and Placebo Effect
- Olfactory and Sensory Function Studies
- Cardiac Health and Mental Health
- Neurological and metabolic disorders
- Mental Health and Psychiatry
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cardiac Imaging and Diagnostics
- Transcranial Magnetic Stimulation Studies
- Mindfulness and Compassion Interventions
- Infrared Thermography in Medicine
- Sympathectomy and Hyperhidrosis Treatments
- Neuropeptides and Animal Physiology
- Gastrointestinal motility and disorders
Danish Pain Research Center
2013-2025
Aarhus University Hospital
2014-2025
Aarhus University
2014-2025
Steno Diabetes Centers
2025
Committee on Publication Ethics
2014
Northwestern University
2012
Williams & Associates
2012
National Postdoctoral Association
2008
Rigshospitalet
2005
The new IASP diagnostic criteria for complex regional pain syndrome (CRPS) (aka "the Budapest Criteria"3; Table 1) have improved the specificity CRPS while maintaining good sensitivity. Internationally, these are now in common use. Special Interest Group convened a workshop of experts Valencia/Spain September 2019 to review perceived ambiguities text and issues identified applying both research clinical contexts. After this review, attendees discussed reached consensus regarding adaptations...
Neuropathic pain in spinal cord injury is a common challenging therapeutic condition. The current study examines the analgesic effect of sodium channel blocker lidocaine on neuropathic patients with and predictive role concomitant evoked relief lidocaine.Twenty-four at or below level were randomized completed double-blind crossover trial 5 mg/kg placebo infused over 30 min. Twelve reported pain, 12 had no pain. Spontaneous pains assessed using visual analog scale quantitative sensory...
Background Complex regional pain syndrome is a painful condition of unknown etiology. Clinical and experimental observations suggest that limb immobilization may induce symptoms signs characteristic complex syndrome. This study examined the effect forearm on sensory autonomic functions in healthy subjects. Methods Thermal mechanical sensitivity, skin temperature, vasoconstrictor responses were measured 30 subjects before 0, 3, 28 days after scaphoid cast immobilization. Fifteen served as...
Parkinson's disease is associated with early parasympathetic dysfunction leading to constipation and gastroparesis. It has been suggested that pathological α-synuclein aggregations originate in the gut ascend brainstem via vagus. Our understanding of pathogenesis time course denervation limited would benefit from a validated imaging technique visualize integrity function. The positron emission tomography tracer 5-[11C]-methoxy-donepezil was recently for acetylcholinesterase density brain...
Abstract Neuronal aggregates of misfolded alpha-synuclein protein are found in the brain and periphery patients with Parkinson’s disease. Braak colleagues have hypothesized that initial formation may start gut, then spread to via peripheral autonomic nerves hereby affecting several organs, including heart intestine. Age is considered greatest risk factor for disease, but effect age on pathology its propagation has not been studied detail. We aimed investigate whether from gut more efficient...
Abstract Background Complex regional pain syndrome is a painful and disabling post‐traumatic primary disorder. Acute chronic complex (CRPS) are major clinical challenges. In Europe, progress hampered by significant heterogeneity in practice. We sought to establish standards for the diagnosis management of CRPS. Methods The European Pain Federation established pan‐European task force experts CRPS who followed four‐stage consensus challenge process produce mandatory quality worded as...
Complex regional pain syndrome (CRPS) is a condition with sensory and autonomic abnormalities in the affected limb. The authors studied systemic hemodynamic function CRPS patients during rest, orthostatic mental arithmetic stress.Twenty 20 age-, sex-, body mass index-matched control subjects participated. Mean values of heart rate variability, baroreceptor sensitivity, blood pressure, stroke volume, cardiac output, total peripheral resistance were estimated supine rest 60° tilt-table...
To investigate the impact of coronavirus-disease-2019 (COVID-19) pandemic on European clinical autonomic practice.Eighty-four neurology-driven or interdisciplinary centers in 22 countries were invited to fill a web-based survey between September and November 2021.Forty-six completed (55%). During first year, number performed tilt-table tests, outpatient inpatient visits decreased respectively by 50%, 45% 53%, every-third center reported major adverse events due postponed examinations visits....
Abstract Aim: Do distraction from‐ or attention to sural nerve stimulation affect pain, heart rate variability, and a spinal withdrawal reflex? Material methods: In 26 male volunteers, electrical at the distal cutaneous receptive field of elicited pain nociceptive reflex. Intensity was rated on numeric rating scale. Electromyographic reflex responses were measured from biceps femoris muscle. Cardiac autonomic function estimated by variability measures expressed in time domain as mean...
Abstract Complex regional pain syndrome (CRPS) is a persistent condition that remains incompletely understood and challenging to treat. Historically, wide range of different outcome measures have been used capture the multidimensional nature CRPS. This has significant limiting factor in advancement our understanding mechanisms management In 2013, an international consortium patients, clinicians, researchers, industry representatives was established, develop agree on minimum core set...
Diabetic neuropathy (DN) affects up to half of individuals with type 1 and 2 diabetes. Despite evidence that improving metabolic cardiovascular health can slow its progression, DN remains a significant clinical challenge due the lack disease-modifying therapies effective pain management strategies. This consensus aimed identify gaps recommend strategies address these challenges. A workshop, initiated by Steno Diabetes Centre Copenhagen Danish Endocrinology Academy, conducted gap analysis...
Introduction The aim of this study was to investigate serum Neurofilament Light polypeptide (NfL) as a biomarker for diabetic polyneuropathy (DPN) in adolescents with type 1 diabetes (T1D). Secondarily, vitamin B 12 (B ) deficiency cause DPN T1D. Research design and methods Cross-sectional study. Sixty Danish T1D (age 15–18 years, duration >5 years) 23 age-matched control subjects were included. Based on nerve conduction studies (NCS), intraepidermal fibre density (IENFD) neurological...
Findings regarding small nerve fiber damage in complex regional pain syndrome type I (CRPS-I) are not uniform, and studies have included a matched healthy control group. The aim was to assess intraepidermal density (IENFD) relation thermal sensitivity of the same skin areas CRPS-I patients gender- age-matched group.IENFD investigated biopsies from CRPS-affected contralateral limbs eight an equivalent site controls (HCs). Thermal thresholds (cold/warm detection, cold- heat-pain detection)...
Complex regional pain syndrome is multifactorial. Exaggerated inflammatory responses to limb injury may be involved. The authors hypothesized that capsaicin-induced and neurogenic inflammation (skin perfusion flare area) are increased in patients with complex compared controls.Twenty unilateral upper-limb 20 age-, sex-, body mass index-matched controls participated. Topical capsaicin 5% was applied the back of both hands for 30 min, intensity assessed on a visual analogue scale. A laser...
Background A maladaptation of the autonomic nervous system may been seen in patients with chronic pain that includes persistent changes tone, increased heart rate, and reduced rate variability baroreflex sensitivity. Baroreflex sensitivity acute intensity have reported to be inversely correlated. However, it is unknown whether same correlation applies regard post‐operative pain. In present study, function was measured scheduled for minor hand surgery correlated early after procedure. Thus,...
Noradrenergic neurotransmission may play an important role in tremor modulation through its innervation of key structures the central circuits. Here, Parkinson's disease (PD) patients with (PDT+) or without (PDT-) rest had 11C-methylreboxetine(11C-MeNER) positron emission tomography (PET) to test hypothesis that noradrenaline terminal function was relatively preserved PDT+ compared PDT-. Sixty-five PD and 28 healthy controls (HC) were scanned 11C-MeNER PET. Patients categorized as if...
A nociceptive withdrawal reflex in 12 human volunteers was elicited by painful electrical stimulation applied to the cutaneous innervation area of sural nerve. The evoked electromyographic activities were recorded with surface electrodes placed on short head biceps femoris muscle ipsi‐lateral nerve stimulation, before, during and after conditioning stimuli. conditioned non‐nociceptive, heterotopic segmental counter‐stimulation. Heterotopic counter‐stimulation induced ice water contra‐lateral...