A5060376366- Pain Mechanisms and Treatments
- Pain Management and Treatment
- Musculoskeletal pain and rehabilitation
- Pain Management and Placebo Effect
- Transcranial Magnetic Stimulation Studies
- Botulinum Toxin and Related Neurological Disorders
- Myofascial pain diagnosis and treatment
- Inflammatory mediators and NSAID effects
- Laser Applications in Dentistry and Medicine
- Migraine and Headache Studies
- Olfactory and Sensory Function Studies
- Psychology, Coaching, and Therapy
- Cancer Treatment and Pharmacology
- Functional Brain Connectivity Studies
- Heart Rate Variability and Autonomic Control
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Pain Management and Opioid Use
- Neural and Behavioral Psychology Studies
- Health and Medical Studies
- Biomedical and Chemical Research
- Anesthesia and Pain Management
- Herpesvirus Infections and Treatments
- Neuroscience and Music Perception
- Neuropeptides and Animal Physiology
- Psychoanalysis and Social Critique
Klinikum Fürth
2015-2025
Klinikum Fulda
2021
Friedrich-Alexander-Universität Erlangen-Nürnberg
2010-2020
Nuremberg Hospital
2020
Johannes Gutenberg University Mainz
2003-2019
University Medical Center of the Johannes Gutenberg University Mainz
2019
University Hospital Brno
2019
Central European Institute of Technology
2019
Masaryk University
2019
GTx (United States)
2018
The nationwide multicenter trials of the German Research Network on Neuropathic Pain (DFNS) aim to characterize somatosensory phenotype patients with neuropathic pain. For this purpose, we have implemented a standardized quantitative sensory testing (QST) protocol giving complete profile for one region within 30 min. To judge plus or minus signs in now established age- and gender-matched absolute relative QST reference values from 180 healthy subjects, assessed bilaterally over face, hand...
Current IASP diagnostic criteria for CRPS have low specificity, potentially leading to overdiagnosis. This validation study compared current proposed new (the "Budapest Criteria") regarding accuracy. Structured evaluations of CRPS-related signs and symptoms were conducted in 113 CRPS-I 47 non-CRPS neuropathic pain patients. Discriminating between groups based on presence or meeting showed high sensitivity (1.00), but poor specificity (0.41), replicating prior work. In comparison, the...
Neuropathic pain is accompanied by both positive and negative sensory signs. To explore the spectrum of abnormalities, 1236 patients with a clinical diagnosis neuropathic were assessed quantitative testing (QST) following protocol DFNS (German Research Network on Pain), using thermal mechanical nociceptive as well non-nociceptive stimuli. Data distributions showed systematic shift to hyperalgesia for nociceptive, hypoesthesia parameters. Across all parameters, 92% presented at least one...
<b><i>Objective:</i></b> To use magnetoencephalography to assess possible cortical reorganization in the primary somatosensory cortex (S1) of patients with complex regional pain syndrome (CRPS). <b><i>Background:</i></b> Patterns and sensory symptoms CRPS may indicate plastic changes CNS. <b><i>Methods:</i></b> Magnetic source imaging was used explore representation digits (D) 1 5 relation lower lip on unaffected affected side 12 patients. <b><i>Results:</i></b> The authors found a...
<b><i>Objective:</i></b> To characterize reorganization of the primary somatosensory cortex (S1) during healing process in complex regional pain syndrome (CRPS). <b><i>Background:</i></b> Recently, authors showed extensive S1 contralateral to CRPS affected side. Predictors for these plastic changes were and extent mechanical hyperalgesia. It is unclear how develop following successful therapy. <b><i>Methods:</i></b> The used magnetic source imaging explore cortical representation digits (D)...
The complex regional pain syndrome (CRPS) is a disabling neuropathic condition that may develop following injuries of the extremities. In present study we sought to characterize motor dysfunction in CRPS patients using kinematic analysis and functional imaging investigations on cerebral representation finger movements. Firstly, 10 12 healthy control subjects were investigated assessing possible changes movement patterns during target reaching grasping. Compared controls, particularly showed...
The new IASP diagnostic criteria for complex regional pain syndrome (CRPS) (aka "the Budapest Criteria"3; Table 1) have improved the specificity CRPS while maintaining good sensitivity. Internationally, these are now in common use. Special Interest Group convened a workshop of experts Valencia/Spain September 2019 to review perceived ambiguities text and issues identified applying both research clinical contexts. After this review, attendees discussed reached consensus regarding adaptations...
Complex Regional Pain Syndromes (CRPS) are characterized by a triad of sensory, motor and autonomic dysfunctions still unknown origin. mechanical hyperalgesia hallmarks CRPS. There several lines evidence that central nervous system (CNS) changes crucial for the development maintenance hyperalgesia. However, little is known about cortical structures associated with processing in pain patients. This study describes use functional magnetic resonance imaging (fMRI) to delineate brain activations...
<b>Objective: </b> To investigate cerebral activations underlying touch-evoked pain (dynamic–mechanical allodynia) in patients with neuropathic pain. <b>Methods: fMRI was used 12 complex regional syndromes (CRPSs). Allodynia elicited by gently brushing the affected CRPS hand. Elicited ratings were recorded online to obtain pain-weighted predictors. Both and deactivations of blood oxygenation level–dependent signals investigated. <b>Results: Nonpainful stimulation on nonaffected hand...
Summary QST revealed more similarities than differences between CRPS-I, CRPS-II, and PNI: sensory loss occurred in 63% of CRPS-I gain 81% PNI patients. This study determined patterns signs complex regional pain syndrome (CRPS) type I II peripheral nerve injury (PNI). Patients with upper-limb (n = 298), CRPS-II 46), 72) were examined quantitative testing according to the protocol German Research Network on Neuropathic Pain. The majority patients (66%–69%) exhibited a combination gain. had...
Visual art represents a powerful resource for mental and physical well-being. However, little is known about the underlying effects at neural level. A critical question whether visual production cognitive evaluation may have different on functional interplay of brain's default mode network (DMN). We used fMRI to investigate DMN non-clinical sample 28 post-retirement adults (63.71 years ±3.52 SD) before (T0) after (T1) weekly participation in two 10-week-long interventions. Participants were...
Transient receptor potential channels are important mediators of thermal and mechanical stimuli play an role in neuropathic pain. The contribution hereditary variants the genes transient to pain is unknown. We investigated frequency ankyrin 1, melastin 8 vanilloid 1 single nucleotide polymorphisms their impact on somatosensory abnormalities patients. Within German Research Network Neuropathic Pain (Deutscher Forscbungsverbund Neuropathischer Schmerz) 371 patients were phenotypically...
The clinical diagnosis of Complex Regional Pain Syndrome (CRPS) is a dichotomous (yes/no) categorization necessary for decision-making. However, such diagnostic categories do not convey an individual's subtle and temporal gradations in severity the condition, have poor statistical power when used as outcome measure research. This study evaluated validity potential utility continuous type score to index CRPS. Psychometric medical evaluations were conducted 114 CRPS patients 41 non-CRPS...
Abstract Limited research suggests that there may be Warm complex regional pain syndrome (CRPS) and Cold CRPS subtypes, with inflammatory mechanisms contributing most strongly to the former. This study for first time used an unbiased statistical pattern recognition technique evaluate whether distinct vs subtypes can discerned in clinical population. An international, multisite was conducted using standardized procedures signs symptoms 152 patients at baseline, 3-month follow-up evaluations...
Reversible defunctionalisation of nociceptors by the TRPV1 agonist capsaicin in high concentration is an emerging new concept for treatment peripheral neuropathic pain.The 8% cutaneous patch with a long-lasting effect up to 3 months after single application available Germany prescription since October 2010. The aim this study was monitor its usage and therapeutic performance clinical practice.Patients had 4 patches were followed 7-14 days, 4, 8, 12 weeks. Average pain intensity (NPRS-11),...
Clinical diagnosis of complex regional pain syndrome (CRPS) is a dichotomous (yes/no) categorization, format necessary for clinical decision making. Such diagnostic categories do not convey an individual's subtle gradations in the severity condition over time and have poor statistical power when used as outcome measure research. This prospective, international, multicenter study slightly modified further evaluated validity CRPS Severity Score (CSS), continuous index severity. Using...