A5049018157- Pain Management and Placebo Effect
- Pain Mechanisms and Treatments
- Empathy and Medical Education
- Complementary and Alternative Medicine Studies
- Musculoskeletal pain and rehabilitation
- Acupuncture Treatment Research Studies
- Pediatric Pain Management Techniques
- Botulinum Toxin and Related Neurological Disorders
- Pain Management and Treatment
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neuroscience, Education and Cognitive Function
- Psychosomatic Disorders and Their Treatments
- Olfactory and Sensory Function Studies
- Music Therapy and Health
- Neurology and Historical Studies
- Pain Management and Opioid Use
- Meta-analysis and systematic reviews
- Mindfulness and Compassion Interventions
- Treatment of Major Depression
- Neuroscience and Music Perception
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Psychology of Moral and Emotional Judgment
- Dental Anxiety and Anesthesia Techniques
- Pharmacology and Obesity Treatment
- Pregnancy-related medical research
Aarhus University
2016-2025
Lundbeck Foundation
2024
Danmarks Frie Forskningsfond
2024
Aarhus University Hospital
2011-2022
Danish Pain Research Center
2010-2021
Radboud University Nijmegen
2016
Leiden University
2016
Leiden University Medical Center
2016
Neuroscience Institute
2016
Radboud University Medical Center
2016
Placebo and nocebo effects occur in clinical or laboratory medical contexts after administration of an inert treatment as part active treatments are due to psychobiological mechanisms such expectancies the patient. studies have evolved from predominantly methodological research into a far-reaching interdisciplinary field that is unravelling neurobiological, behavioural underpinnings these phenomena broad variety conditions. As consequence, there increasing demand health professionals develop...
Control interventions (often called "sham," "placebo," or "attention controls") are essential for studying the efficacy mechanism of physical, psychological, and self-management in clinical trials. This article presents core recommendations designing, conducting, reporting control to establish a quality standard non-pharmacological intervention research. A framework additional considerations supports researchers' decision making this context. We also provide checklist enhance research...
In order to investigate external factors that may influence the magnitude of placebo analgesia as well psychological mediate analgesia, 13 irritable bowl syndrome (IBS) patients rated evoked rectal distension and cutaneous heat pain under conditions natural history (NH), (RP), nocebo (RN), lidocaine (RL) oral (OL). Patients were given verbal suggestions for relief expected levels desire both visceral pain, respectively. Large reductions in intensity unpleasantness ratings found RP, RL OL...
A study was conducted to determine whether changes in expected pain levels, desire for relief, or anxiety contribute an increase placebo analgesia over time as well analgesic effects of IBS patients are related endogenous opioid mechanisms. Twenty-six women with were exposed rectal stimulation (35 55 mmHg 30 s) and tested under natural history (NH), (RP) lidocaine (RL) conditions. During all conditions, 16 given saline intravenously (to test a effect) 10 naloxone antagonism the on double...
Irritable bowel syndrome (IBS) is one of the most common gastrointestinal illnesses and characterized by altered visceral perception. The aim study was to determine if local anesthetic blockade peripheral nociceptive input reduces both cutaneous secondary hyperalgesia in IBS patients. Ten women with (mean age 30±10 years) ten control subjects (all women) 29±7 rated pain intensity unpleasantness distension rectum (35 mmHg) thermal stimulation (47 °C) foot before after rectal administration...
Recent meta-analyses find various magnitudes of placebo analgesia effects in mechanism trials versus control trials, which have led to debate. To further investigate the magnitude databases "PubMed", "PsycINFO" and "Web Science" (2002-2007) were searched with term "placebo analgesia". Twenty-one articles including 24 studies fulfilled selection criteria (concerning: mechanisms, control, treatment, randomization pain measures). The validity was assessed by authors effect sizes calculated via...
The pain in Fibromyalgia (FM) is difficult to treat and functional mobility seems be an important comorbidity these patients that could evolve into a disability. In this study we wanted investigate the analgesic effects of music FM pain. Twenty-one were passively exposed 1) self-chosen, relaxing, pleasant music, 2) control auditory condition (pink noise). They rated performed "timed-up & go task (TUG)" measure after each condition. Listening pleasant, self-chosen reduced increased...
<b><i>Introduction:</i></b> Clinical and laboratory studies demonstrate that placebo nocebo effects influence various symptoms conditions after the administration of both inert active treatments. <b><i>Objective:</i></b> There is an increasing need for up-to-date recommendations on how to inform patients about in clinical practice train clinicians disclose this information. <b><i>Methods:</i></b> Based previous...
Despite standard medical treatment endometriosis is often associated with disabling pain and poor quality of life (QoL). Studies indicate that psychological interventions (PIs) may improve QoL, yet studies on the effects PIs for women are sparse limited by low-quality study designs. Therefore, this aimed, in a rigorous three-armed design, to evaluate effect chronic pelvic (CPP) QoL endometriosis.
Peripheral mechanisms are known to play a role in phantom pain following limb amputation, and more recently it has been suggested that central may also be of importance. Some patients seem have psychological sensitivity predisposes them react with catastrophizing after amputation limb, this coping style contribute increased facilitation, impaired modulation nociceptive signals, or both. To investigate how catastrophizing, independently anxiety depression, alterations processing twenty-four...
Several studies have shown that placebo analgesia effects can be obtained in healthy volunteers, as well patients suffering from acute postoperative pain and chronic conditions such irritable bowel syndrome. However, it is unknown whether elicited with a known pathophysiology nerve injury. Nineteen who had developed neuropathic after thoracotomy were exposed to manipulation which they received either open or hidden administrations of lidocaine. Before the treatment, rated their levels...
Research on placebo analgesia and nocebo hyperalgesia has primarily included healthy subjects or acute pain patients, it is unknown whether these effects can be obtained in ongoing patients with chronic caused by an identifiable nerve injury. Eighteen postthoracotomy neuropathic were exposed to manipulations, which they received open hidden administrations of pain-relieving (lidocaine) pain-inducing (capsaicin) treatment controlled for the natural history pain. Immediately after...
Background Variability in patients' postoperative pain experience and response to treatment challenges effective management. reflects individual differences inhibitory modulation psychological sensitivity, which turn may be clinically relevant for the disposition acquire pain. The aim of this study was investigate effects conditioned situational catastrophizing on persistency. Methods Preoperatively, 42 healthy males undergoing funnel chest surgery completed Spielberger's State-Trait Anxiety...