A5102725373- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Pain Management and Placebo Effect
- Mental Health Research Topics
- Functional Brain Connectivity Studies
- Olfactory and Sensory Function Studies
- Child and Adolescent Psychosocial and Emotional Development
- Biochemical Analysis and Sensing Techniques
- Treatment of Major Depression
- Neural and Behavioral Psychology Studies
- Migraine and Headache Studies
- Advanced Chemical Sensor Technologies
- Psychosomatic Disorders and Their Treatments
- Perfectionism, Procrastination, Anxiety Studies
- Pediatric Pain Management Techniques
- Neuroscience, Education and Cognitive Function
- Stress Responses and Cortisol
- Neurology and Historical Studies
- Creativity in Education and Neuroscience
- Neuroscience and Music Perception
- Nicotinic Acetylcholine Receptors Study
- Psychological Well-being and Life Satisfaction
- Cognitive Abilities and Testing
- Advanced Statistical Modeling Techniques
- Complementary and Alternative Medicine Studies
- Musculoskeletal pain and rehabilitation
Center for Pain and the Brain
2014-2024
Boston Children's Hospital
2014-2024
TU Dresden
2019-2024
Uppsala University
2008-2024
University Hospital Carl Gustav Carus
2023-2024
Harvard University
2014-2023
Beth Israel Deaconess Medical Center
2015-2023
Boston University
2020
Massachusetts General Hospital
2014-2016
Control interventions (often called "sham," "placebo," or "attention controls") are essential for studying the efficacy mechanism of physical, psychological, and self-management in clinical trials. This article presents core recommendations designing, conducting, reporting control to establish a quality standard non-pharmacological intervention research. A framework additional considerations supports researchers' decision making this context. We also provide checklist enhance research...
Placebo may yield beneficial effects that are indistinguishable from those of active medication, but the factors underlying proneness to respond placebo widely unknown. Here, we used functional neuroimaging examine neural correlates anxiety reduction resulting sustained treatment under randomized double-blind conditions, in patients with social disorder. Brain activity was assessed during a stressful public speaking task by means positron emission tomography before and after an 8 week...
Serotonin is involved in negative affect, but whether anxiety syndromes, such as social disorder (SAD), are characterized by an overactive or underactive serotonin system has not been established. 1A autoreceptors, which inhibit synthesis and release, downregulated SAD, transporter availability might be increased; however, presynaptic activity evaluated extensively.To examine the rate patients with SAD healthy control individuals using positron emission tomography (PET) radioligands...
In Brief The prevalence of migraine has an exponential trajectory that is most obvious in young females between puberty and early adulthood. Adult are affected twice as much males. During development, hormonal changes may act on predetermined brain circuits, increasing the probability migraine. However, little known about pediatric evolution. Using magnetic resonance imaging, we evaluated 28 children with (14 14 males) sex-matched healthy controls to determine differences structure function...
Highlights•Overt surpassed covert SSRI treatment with doubled effect size and tripled response rate on the main social anxiety outcome.•Overt vs. yielded different neural changes in brain areas involved emotion-cognition interactions.•This study suggests that presentation of a may be as important itself.Using truthful or deceiving verbal instructions, we tested how expectancies influence efficacy disorder. The number responders was more than three times higher after open administration...
Social anxiety disorder (SAD) can come in different forms, presenting problems for diagnostic classification. Here, we examined personality traits a large sample of patients (N = 265) diagnosed with SAD comparison to healthy controls 164) by use the Revised NEO Personality Inventory (NEO-PI-R) and Karolinska Scales (KSP). In addition, identified subtypes based on cluster analysis NEO-PI-R Big Five dimensions. Significant group differences between were noted all dimensions except...
Background Selective serotonin reuptake inhibitors (SSRIs) and cognitive–behavioural therapy (CBT) are often used concomitantly to treat social anxiety disorder (SAD), but few studies have examined the effect of this combination. Aims To evaluate whether adding escitalopram internet-delivered CBT (ICBT) improves clinical outcome alters brain reactivity connectivity in SAD. Method Double-blind, randomised, placebo-controlled neuroimaging trial ICBT combined either with ( n = 24) or placebo...
Abstract It has been extensively debated whether selective serotonin reuptake inhibitors (SSRIs) are more efficacious than placebo in affective disorders, and it is not fully understood how SSRIs exert their beneficial effects. Along with transporter blockade, altered dopamine signaling psychological factors may contribute. In this randomized clinical trial of participants social anxiety disorder (SAD) we investigated manipulation verbally-induced expectancies, vital for response, affect...
Accumulating data emphasizes the importance of olfaction in migraine pathophysiology. However, there are only a few studies evaluating how brain processes olfactory stimulation, and virtually no comparing patients with without aura this context.This cross-sectional study recorded event-related potentials from 64 electrodes during pure or trigeminal stimulus females episodic (n = 13) 15), to characterize central nervous processing these intranasal stimuli. Patients were tested interictal...
In patients with social anxiety disorder (SAD) it has been reported that selective serotonin reuptake inhibitors (SSRIs) and placebo induce anxiolytic effects by attenuating neural activity in overlapping amygdala subregions, i.e. left basolateral right ventrolateral amygdala. However, is not known whether these treatments inhibit subregions via similar or distinct brain pathways. As may alter amygdala-frontal couplings we investigated differences similarities functional co-activation...
<b><i>Introduction:</i></b> Patients with chemosensory dysfunction frequently report symptoms of depression. The current study aims to clarify whether the type (smell dysfunction, taste and mixed smell dysfunction), severity, duration, or cause have differential impacts on <b><i>Methods:</i></b> 899 patients disorders 62 controls were included. Following a structured interview an otorhinolaryngological examination, subjects underwent olfactory...
Social anxiety disorder (SAD) is associated with aberrant emotional information processing while little known about non-emotional cognitive biases. The dorsal anterior cingulate cortex (dACC) has been implicated in SAD neuropathology and activated both by non-affective challenges like the Multisource Interference Task (MSIT).Here, we used fMRI to compare dACC activity test performance during MSIT 69 patients 38 healthy controls. In addition patient-control comparisons, examined whether...
Much is known about the effect of odors on mood, cognition and behavior, but little relationship between well-being. We investigated neural processing with different degrees association well-being (WB) through two large independent datasets. The study encompassed pre-testing fMRI. During pre-testing, 100 80 (studies 1 2) young, healthy subjects participated, rating intensity, valence, WB for 14 (study 1) 8 odors. Pre-testing resulted in selection high (WB-associated) lower (neutral odors)...
Objective Functional magnetic resonance imaging (fMRI) is a non‐invasive neuroimaging technique widely used in olfactory research. During typical fMRI block‐design, one functional “run” refers to combination of multiple blocks with continuous brain image acquisition. The current study investigated the length runs on odor‐induced response signals (blood oxygen level dependent [BLOD]) within primary and key secondary areas. Methods Twenty‐five female adults (age range 19 30 years, mean age 25...
Olfactory loss can be acquired (patients with a history of olfactory experiences), or inborn without experiences/life-long inability to smell). Inborn loss, congenital anosmia (CA), is relatively rare and there knowledge gap regarding the compensatory neural mechanisms involved in this condition. The study aimed investigate top-down processing patients CA idiopathic (IA) comparison normosmia controls (NC) during expectancy reading odor-associated words. Functional magnetic resonance imaging...