A5030315869- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Neuropeptides and Animal Physiology
- Nicotinic Acetylcholine Receptors Study
- Functional Brain Connectivity Studies
- Tryptophan and brain disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Treatment of Major Depression
- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- Mental Health Research Topics
- Heart Rate Variability and Autonomic Control
- Neural and Behavioral Psychology Studies
- Neuroscience and Neural Engineering
- Pain Management and Placebo Effect
- Monoclonal and Polyclonal Antibodies Research
- Schizophrenia research and treatment
- Pain Mechanisms and Treatments
- Regulation of Appetite and Obesity
- Neural dynamics and brain function
- SARS-CoV-2 and COVID-19 Research
- Pluripotent Stem Cells Research
- Hypothalamic control of reproductive hormones
FIT Consulting (Italy)
2024
Alfasigma (Italy)
2021-2023
Takeda (Switzerland)
2018-2022
Imperial College London
2015-2021
Takeda (Japan)
2020-2021
Takeda (United Kingdom)
2015-2018
Howard University
2018
Charité - Universitätsmedizin Berlin
2018
University of Brescia
2013-2018
University of Basel
2018
<h3>Background</h3> Depression is associated with interpersonal difficulties related to abnormalities in affective facial processing. <h3>Objectives</h3> To map brain systems activated by sad affect processing patients depression and identify functional correlates of antidepressant treatment symptomatic response. <h3>Design</h3> Two groups underwent scanning twice using magnetic resonance imaging (fMRI) during an 8-week period. The event-related fMRI paradigm entailed incidental recognition...
The function of neuropeptide Y, one the most abundant peptide transmitters mammalian brain, remains unclear because a lack specific receptor antagonists. An antisense oligodeoxynucleotide corresponding to NH 2 -terminus rat Y1 was constructed and added cultures cortical neurons. This treatment resulted in reduced density (but not Y2) receptors diminished decrease adenosine 3′,5′-monophosphate (cAMP) usually seen after activation. Repeated injection same into lateral cerebral ventricle rats...
Regional brain activation was assessed by mapping of Fos-related protein expression in rats trained to self-administration intravenous nicotine and cocaine. Both drugs produced specific overlapping patterns the shell core nucleus accumbens, medial prefrontal cortex, caudate areas, but not amygdala. Thus, reinforcing properties cocaine map on selected structures terminal fields mesocorticolimbic dopamine system, supporting idea that common substrates for these addictive exist.
Processing affective facial expressions is an important component of interpersonal relationships. However, depressed patients show impairments in this system. The present study investigated the neural correlates implicit processing happy depression and identified regions affected by antidepressant therapy.Two groups subjects participated a prospective with functional magnetic resonance imaging (fMRI). were 19 medication-free (mean age, 43.2 years) major depression, acute depressive episode,...
Placebo may yield beneficial effects that are indistinguishable from those of active medication, but the factors underlying proneness to respond placebo widely unknown. Here, we used functional neuroimaging examine neural correlates anxiety reduction resulting sustained treatment under randomized double-blind conditions, in patients with social disorder. Brain activity was assessed during a stressful public speaking task by means positron emission tomography before and after an 8 week...
The antiparkinsonian ropinirole and pramipexole are D3 receptor- (D3R-) preferring dopaminergic (DA) agonists used as adjunctive therapeutics for the treatment resistant depression (TRD). While exact antidepressant mechanism of action remains uncertain, a role D3R in restoration impaired neuroplasticity occurring TRD has been proposed. Since highly expressed on DA neurons humans, we studied effect structural plasticity using translational model human-inducible pluripotent stem cells...
The Gut Microbiome-Liver-Brain Axis is a relatively novel construct with promising potential to enhance our understanding of Alcohol Use Disorder (AUD), and its therapeutic approaches. Significant alterations in the gut microbiome occur AUD even before any other systemic signs or symptoms manifest. Prolonged inappropriate alcohol consumption, by affecting microbiota mucosa permeability, thought contribute development behavioral cognitive impairments, leading Alcohol-Related Liver Disorders...
Abstract The aim of the present experiment was to study effects early postnatal maternal separation on behavioural and adrenocortical responses novelty in rats tested as adults. Sprague–Dawley rat pups were exposed daily (5 h/day) from day 2 6, during stress hyporesponsive period. Since this procedure requires physical contact with animals, a first control group handled introduced. A second group, consisting never or separated mother, also considered. At 45, two‐compartment exploratory...