A5059837830- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Diet and metabolism studies
- Cannabis and Cannabinoid Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Regulation of Appetite and Obesity
- Pharmacological Effects and Toxicity Studies
- Ion channel regulation and function
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Neurological disorders and treatments
- Photoreceptor and optogenetics research
- Biochemical Analysis and Sensing Techniques
- Parkinson's Disease Mechanisms and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Stress Responses and Cortisol
- Genetics and Neurodevelopmental Disorders
- Neuroendocrine regulation and behavior
- Lysosomal Storage Disorders Research
- Mitochondrial Function and Pathology
- Anesthesia and Neurotoxicity Research
- Receptor Mechanisms and Signaling
- Metabolism and Genetic Disorders
- Neuropeptides and Animal Physiology
- Drug Transport and Resistance Mechanisms
University of Modena and Reggio Emilia
2016-2025
Polyclinic Medical Center
2018
Montreal Neurological Institute and Hospital
2000-2015
McGill University
2000-2015
University of Bologna
2015
Centro Interuniversitario di Ricerca Per lo Sviluppo sostenibile
2002
Université de Montréal
2001
Montreal Clinical Research Institute
2001
Istituti di Ricovero e Cura a Carattere Scientifico
1994
University of Milan
1991-1992
Abstract Cannabis is a multifaceted plant with numerous therapeutic properties on one hand, and controversial psychotropic activities the other which are modulated by CB1 endocannabinoid receptors. Δ9-Tetrahydrocannabinol (Δ9-THC) has been identified as main component responsible for effects, while its constitutional isomer cannabidiol (CBD) shown completely different pharmacological properties. Due to reported beneficial gained global popularity openly sold in shops online. To circumvent...
Proton receptors of the acid-sensing ion channel (ASIC) family are expressed in sensory neurons and thus could play a critical role detection noxious acidosis. To investigate subunit composition native ASICs peripheral central neurons, we co-injected human as well rodent ASIC2a ASIC3 subunits in<i>Xenopus</i> oocytes. The amplitudes acid-induced biphasic responses mediated by co-expressed were much larger (as 20-fold) than currents respective homomers, clearly indicating functional...
Abstract The aim of the present experiment was to study effects early postnatal maternal separation on behavioural and adrenocortical responses novelty in rats tested as adults. Sprague–Dawley rat pups were exposed daily (5 h/day) from day 2 6, during stress hyporesponsive period. Since this procedure requires physical contact with animals, a first control group handled introduced. A second group, consisting never or separated mother, also considered. At 45, two‐compartment exploratory...
Interictal spiking is seen in the EEG of epileptic patients between seizures. To date, roles played by interictal events seizure occurrence and epileptogenesis remain elusive. While spikes may herald onset electrographic seizures, experimental data indicate that hippocampus-driven prevent precipitation. Even less clear than role whether how contribute to epileptogenesis. Thus, while plastic changes within limbic neuronal networks result from ongoing activity, evidence supports view...
Multiple sclerosis (MS) is an autoimmune demyelinating disorder of the central nervous system (CNS) characterized by loss myelin accompanied infiltration T‐lymphocytes and monocytes. Although it has been shown that these infiltrates are important for progression MS, role microglia, resident macrophages CNS, remains ambiguous. Therefore, we have compared phenotypes microglia in a mouse model experimental encephalomyelitis (EAE). In order to properly discriminate between two cell types, were...
We established the effects of antiepileptic drugs (AEDs) carbamazepine (CBZ), topiramate (TPM), and valproic acid (VPA) on epileptiform activity induced by 4-aminopyridine (4AP) in rat entorhinal cortex (EC) an vitro brain slice preparation.Brain slices were obtained from Sprague-Dawley rats (200-250 g). Field intracellular recordings made EC during bath application 4AP (50 microm). AEDs, some experiments, picrotoxin applied concomitantly.Prolonged (>3 s), ictal-like events abolished CBZ...
Activated microglia, astrogliosis, expression of pro-inflammatory cytokines, blood brain barrier (BBB) leakage and peripheral immune cell infiltration are features mesial temporal lobe epilepsy. Numerous studies correlated the cytokines with activated morphology attributing them a pro-epileptogenic role. However, microglia myeloid cells such as macrophages have always been difficult to distinguish due an overlap in expressed surface molecules. Thus, detrimental role epilepsy that is...
We evaluated the effects of cannabidiol (CBD) on seizures and peroxisome proliferator-activated receptor gamma (PPARγ) levels in an animal model temporal lobe epilepsy (TLE). Adult male Sprague-Dawley rats were continuously monitored by video-electrocorticography up to 10 weeks after intraperitoneal kainic acid (15 mg/kg) injection. Sixty-seven days induction status epilepticus appearance spontaneous recurrent all rats, CBD was dissolved medium-chain triglyceride (MCT) oil administered...
Abstract Trilostane is a 3β‐hydroxysteroid dehydrogenase/Δ 5‐4 isomerase inhibitor able to produce manyfold increase in brain levels of various neurosteroids, including allopregnanolone. We previously found that treatment with trilostane can slow down epileptogenesis the kainic acid (KA) model temporal lobe epilepsy. It unknown whether may have similar effect on progression epilepsy severity, as observed KA‐treated rats. Consequently, we investigated effects (50 mg/kg/day, 1 week) epileptic...
In this study, we used in vitro electrophysiology along with immunohistochemistry and molecular techniques to study the subiculum--a limbic structure that gates information flow from hippocampus--in pilocarpine-treated epileptic rats. Comparative data were obtained age-matched nonepileptic controls (NEC). Subicular neurons hippocampal-entorhinal cortex (EC) slices of rats were: (i) hyperexcitable when activated by CA1 or EC inputs; (ii) generated spontaneous postsynaptic potentials at higher...