A5002062858- Pain Management and Placebo Effect
- Empathy and Medical Education
- Pain Mechanisms and Treatments
- Complementary and Alternative Medicine Studies
- Psychosomatic Disorders and Their Treatments
- Acupuncture Treatment Research Studies
- Pediatric Pain Management Techniques
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Musculoskeletal pain and rehabilitation
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Mindfulness and Compassion Interventions
- Clinical Reasoning and Diagnostic Skills
- Patient-Provider Communication in Healthcare
- Optimism, Hope, and Well-being
- Dermatology and Skin Diseases
- Mental Health and Psychiatry
- Neuroscience, Education and Cognitive Function
- Sport Psychology and Performance
- Music Therapy and Health
- Psychology of Moral and Emotional Judgment
- Motivation and Self-Concept in Sports
- Patient Satisfaction in Healthcare
- Nuts composition and effects
- COVID-19 and Mental Health
- Innovations in Medical Education
Leiden University
2016-2025
Netherlands Institute for Neuroscience
2021
Radboud University Nijmegen
2015-2016
Radboud University Medical Center
2015-2016
Maastricht University
2016
Leiden University Medical Center
2016
Aarhus University
2016
Danish Pain Research Center
2016
Aarhus University Hospital
2016
Placebo and nocebo effects occur in clinical or laboratory medical contexts after administration of an inert treatment as part active treatments are due to psychobiological mechanisms such expectancies the patient. studies have evolved from predominantly methodological research into a far-reaching interdisciplinary field that is unravelling neurobiological, behavioural underpinnings these phenomena broad variety conditions. As consequence, there increasing demand health professionals develop...
Control interventions (often called "sham," "placebo," or "attention controls") are essential for studying the efficacy mechanism of physical, psychological, and self-management in clinical trials. This article presents core recommendations designing, conducting, reporting control to establish a quality standard non-pharmacological intervention research. A framework additional considerations supports researchers' decision making this context. We also provide checklist enhance research...
Nocebo effects, i.e., adverse treatment effects which are induced by patients' expectations, known to contribute the experience of physical symptoms such as pain and itch. A better understanding how minimize nocebo responses might eventually enhanced effects. However, little is about reduce In current randomized controlled study, we tested whether can be minimized positive expectation induction with respect electrical histaminic itch stimuli. First, negative expectations stimuli were verbal...
Abstract Mental imagery is a highly common component of everyday cognitive functioning. While substantial progress being made in clarifying this fundamental human function, much still unclear or unknown. A more comprehensive account mental aspects would be gained by examining individual differences age, sex, and background experience an activity their association with different modalities intentionality levels. The current online study combined multiple self-report measures sample ( n = 279)...
Abstract Objectives Placebo effects can relieve acute and chronic pain in both research clinical treatments by learning mechanisms. However, the application of placebo‐based treatment strategies routine medical care is questioned. The current study investigated opinions patients with fibromyalgia healthy controls regarding placebo their practical applications. Method An online survey asked 158 age‐ sex‐matched adult (79 per group) to rate perceived influence various mechanisms on relief,...
Research into placebo effects has convincingly shown that inducing positive outcome expectations can reduce pain and other physical sensations. However, the comparative of different expectation inductions, such as verbal suggestion or mental imagery, their generic on sensitivity, to sensations pain, itch, fatigue, are still largely unknown. In current study, we assessed individual combined imagery fatigue indicators sensitivity in a randomized study design. Healthy participants (n = 116)...
Background: Information provision about prognosis, treatments, and side-effects is important in advanced cancer, yet also associated with impaired patient well-being. To counter potential detrimental effects, communication strategies based on placebo nocebo effect mechanisms might be promising to apply daily practice. This study aimed provide more insight into how often oncologists use expectancy empathy expressions consultations patients breast cancer. Methods: Forty-five between were...
Itch is often regarded as unpleasant or bothersome and accompanied by symptoms of distress impairments in daily life. The biopsychosocial model chronic itch describes how psychological factors can contribute to the improvement exacerbation related scratching behaviour. Recent research underlines important role cognitive-affective information processing, such attention, affect expectancies. This may not only play a for acute states, but particularly apply process chronification, example, due...
Abstract Nocebo hyperalgesia is a clinically relevant phenomenon and may be formed as result of associative learning, implemented by classical conditioning. This study explored for the first time distinct nocebo conditioning methods their consequences attenuation methods. Healthy participants (N = 140) were recruited randomized to following induction groups: with continuous reinforcement (CRF), partial (PRF), sham-conditioning control group. In phase, counterconditioning was compared...
Expectancies can shape pain and other experiences. Generally, experiences change in the direction of what is expected (ie, assimilation effects), as seen with placebo effects. However, case large expectation-experience discrepancies, might away from contrast effects). Previous research has demonstrated effects on various outcomes, but not pain. We investigated strong underpredictions experienced intensity. In addition, we assessed related outcomes including (certainty of) expectations, fear...
Abstract Pain and other somatosensory sensations, such as itch, can be effectively decreased by placebo effects increased nocebo effects. There are indications that on pain generalize to sensations within itch modalities. However, it has not yet been investigated whether learned stimulus modalities or from itch. Our aims were test modalities, ie, heat pressure pain, across with psychophysiological similarities, cowhage-evoked For this purpose, 65 healthy participants randomized either a...
Abstract Background The effects of many treatments in healthcare are determined by factors other than the treatment itself. Patients’ expectations and relationship with their provider can significantly affect outcomes thereby play a major role eliciting placebo nocebo effects. We aim to develop evaluate an innovative communication training, consisting e-learning virtual reality (VR) for providers across all disciplines, optimize minimize through provider-patient communication. current paper...
Abstract Background Placebo effects on pain have been found to vary in size for different routes of medication administration (e.g. oral vs. injection). This has important implications both clinical research and practice. To enhance our understanding these differential placebo effects, the underlying expectations about multiple symptoms other than is vital. Methods A cross‐sectional, Internet‐based survey was conducted a representative sample Dutch population ( n = 508). Respondents rated...
Abstract Background Placebo effects on pain are reliably observed in the literature. A core mechanism of these is response expectancies. Response expectancies can be formed by instructions, prior experiences and observation others. Whether mental imagery a also induce placebo‐like expectancy has not yet been studied systematically. Methods In Study 1, 80 healthy participants were randomly allocated to (i) or (ii) control imagery. 2, 135 with verbal suggestion regarding its effectiveness,...
This study investigated for the first time effects of individual and combined application 3 learning techniques (verbal suggestions, classical conditioning, observational learning) on placebo analgesia extinction. Healthy participants (N = 206) were assigned to 8 different groups in which they taught through either a verbal suggestion, conditioning paradigm, video observing someone, or any combination thereof that device (inactive transcutaneous electric nerve stimulation [TENS]) was capable...
Nocebo effects can adversely affect the experience of physical symptoms, such as pain and itch. on itch have shown to be induced by conditioning with thermal heat stimuli reduced counterconditioning. However, open-label counterconditioning, in which participants are informed about placebo content treatment, has not been investigated, while this highly relevant for clinical practice. Furthermore, (open-label) counterconditioning investigated modalities musculoskeletal disorders, pressure...
Despite the increasing knowledge about placebo effects and their beneficial impact on treatment outcomes, strategies that explicitly employ these mechanisms remain scarce. To benefit from effects, it is important to gain better understanding in how individuals want be informed (for example underlying steer effects). The main aim of this study was investigate information a general population sample by assessing current knowledge, preferences for different explanations (built around well-known...