A5041962211- Pain Management and Placebo Effect
- Pain Mechanisms and Treatments
- Empathy and Medical Education
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Musculoskeletal pain and rehabilitation
- COVID-19 and Mental Health
- Psychosomatic Disorders and Their Treatments
- Neuroscience, Education and Cognitive Function
- Mental Health Research Topics
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Heart Rate Variability and Autonomic Control
- Mindfulness and Compassion Interventions
- Mental Health via Writing
- Neuroendocrine regulation and behavior
- Pediatric Pain Management Techniques
- Neural dynamics and brain function
- Olfactory and Sensory Function Studies
- Psychology of Moral and Emotional Judgment
- Infrared Thermography in Medicine
- Computational and Text Analysis Methods
- Misinformation and Its Impacts
- Sentiment Analysis and Opinion Mining
National Institutes of Health
2016-2025
National Center for Complementary and Integrative Health
2016-2025
National Institute of Mental Health
2019-2025
National Institute on Drug Abuse
2016-2025
Duke University
2023
University of Baltimore
2023
Seattle University
2022
University of California, Riverside
2021
University of Pittsburgh
2021
Texas Health Dallas
2021
Persistent pain is measured by means of self-report, the sole reliance on which hampers diagnosis and treatment. Functional magnetic resonance imaging (fMRI) holds promise for identifying objective measures pain, but brain that are sensitive specific to physical have not yet been identified.In four studies involving a total 114 participants, we developed an fMRI-based measure predicts intensity at level individual person. In study 1, used machine-learning analyses identify pattern fMRI...
Placebo and nocebo effects occur in clinical or laboratory medical contexts after administration of an inert treatment as part active treatments are due to psychobiological mechanisms such expectancies the patient. studies have evolved from predominantly methodological research into a far-reaching interdisciplinary field that is unravelling neurobiological, behavioural underpinnings these phenomena broad variety conditions. As consequence, there increasing demand health professionals develop...
Information about upcoming pain strongly influences experience in experimental and clinical settings, but little is known the brain mechanisms that link expectation experience. To identify pathways by which informational cues influence perception, analyses must jointly consider both effects of on responses relationship between changes reported Our task analysis strategy were designed to test these relationships. Auditory elicited expectations for barely painful or highly thermal stimulation,...
Recent studies have identified brain correlates of placebo analgesia, but none assessed how accurately patterns activity can predict individual differences in responses. We reanalyzed data from two fMRI analgesia ( N = 47), using during the anticipation and experience pain to new subjects' scores on placebo-induced changes processing. used a cross-validated regression procedure, LASSO-PCR, which provided both unbiased estimates predictive accuracy interpretable maps regions are most...
Abstract Cerebral processes contribute to pain beyond the level of nociceptive input and mediate psychological behavioural influences. However, cerebral contributions nociception are not yet well characterized, leading a predominant focus on when studying developing interventions. Here we use functional magnetic resonance imaging combined with machine learning develop multivariate pattern signature—termed stimulus intensity independent signature-1 (SIIPS1)—that predicts above in four...
Placebo treatments and opiate drugs are thought to have common effects on the opioid system pain-related brain processes. This has created excitement about potential for expectations modulate drug themselves. If differ as a function of belief, this would challenge assumptions underlying standard clinical trial. We conducted two studies directly examine relationship between analgesia. administered agonist remifentanil human subjects during experimental thermal pain manipulated participants9...
Recent human neuroimaging studies have investigated the neural correlates of either noxious stimulus intensity or reported pain. Although useful, analyzing brain relationships with and behavior separately does not address how sensation pain are linked in central nervous system. In this study, we used multi-level mediation analysis to identify mediators pain--regions which trial-by-trial responses heat explained variability relationship between (across 4 levels) This approach has potential...
There has been extensive discussion about gender gaps in representation and career advancement the sciences. However, psychological science itself yet to be focus of or systematic review, despite our field’s investment questions equity, status, well-being, bias, disparities. In present article, we consider 10 topics relevant for women’s science. We on issues that have subject empirical study, discuss evidence within outside science, draw established theory social-science research begin chart...
We examined the complex relationship between depression, anxiety, and seizure control quality of life (QOL) outcomes after epilepsy surgery.Seven centers enrolled 373 patients completed a comprehensive diagnostic workup psychiatric follow-up QOL evaluation. Subjects were evaluated before surgery then at 3, 6, 12, 24, 48, 60 months surgery. Standardized assessments included Quality Life in Epilepsy Inventory-89, Beck Depression Inventory (BDI), Anxiety (BAI). A mixed-model repeated-measures...
Socially-conveyed rules and instructions strongly shape expectations emotions. Yet most neuroscientific studies of learning consider reinforcement history alone, irrespective knowledge acquired through other means. We examined fear conditioning reversal in humans to test whether instructed modulates the neural mechanisms feedback-driven learning. One group was informed about contingencies reversals. A second learned only from reinforcement. combined quantitative models with functional...
<b><i>Introduction:</i></b> Clinical and laboratory studies demonstrate that placebo nocebo effects influence various symptoms conditions after the administration of both inert active treatments. <b><i>Objective:</i></b> There is an increasing need for up-to-date recommendations on how to inform patients about in clinical practice train clinicians disclose this information. <b><i>Methods:</i></b> Based previous...
Background Health care providers and health-related researchers face significant challenges when applying sentiment analysis tools to free-text survey data. Most state-of-the-art applications were developed in domains such as social media, their performance the health context remains relatively unknown. Moreover, existing studies indicate that these often lack accuracy produce inconsistent results. Objective This study aims address of comparative on applied data COVID-19. The objective was...
Human neuroimaging offers a powerful way to connect animal and human research on emotion, with profound implications for psychological science. However, the gulf between studies remains formidable obstacle: typically focus cortex few subcortical regions such as amygdala, whereas deeper structures brainstem periaqueductal gray (PAG) play key role in models. Here, we directly assessed of PAG affect by interleaving single fMRI session two conditions known elicit strong emotional...