A5059772146- Acupuncture Treatment Research Studies
- Pain Management and Placebo Effect
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Musculoskeletal pain and rehabilitation
- Psychosomatic Disorders and Their Treatments
- Heart Rate Variability and Autonomic Control
- Pain Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Vagus Nerve Stimulation Research
- Complementary and Alternative Medicine Studies
- Migraine and Headache Studies
- Advanced MRI Techniques and Applications
- EEG and Brain-Computer Interfaces
- Advanced Neuroimaging Techniques and Applications
- Gastrointestinal motility and disorders
- Pain Management and Treatment
- Traditional Chinese Medicine Studies
- Peripheral Nerve Disorders
- Myofascial pain diagnosis and treatment
- Trigeminal Neuralgia and Treatments
- Transcranial Magnetic Stimulation Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Dermatology and Skin Diseases
- Empathy and Medical Education
- Atomic and Subatomic Physics Research
Athinoula A. Martinos Center for Biomedical Imaging
2016-2025
Harvard University
2016-2025
Massachusetts General Hospital
2016-2025
Brigham and Women's Hospital
2015-2025
Spaulding Rehabilitation Hospital
2021-2025
Logan University
2015-2024
Politecnico di Milano
2015-2024
National Center for Complementary and Integrative Health
2023
Institute of Art
2023
Chestnut Hill College
2015-2022
Abstract Objective Fibromyalgia (FM) is considered to be the prototypical central chronic pain syndrome and associated with widespread that fluctuates spontaneously. Multiple studies have demonstrated altered brain activity in these patients. The objective of this study was investigate degree connectivity between multiple networks patients FM, as well how correlates level spontaneous pain. Methods Resting‐state functional magnetic resonance imaging (FMRI) data from 18 FM age‐matched healthy...
Placebo and nocebo effects occur in clinical or laboratory medical contexts after administration of an inert treatment as part active treatments are due to psychobiological mechanisms such expectancies the patient. studies have evolved from predominantly methodological research into a far-reaching interdisciplinary field that is unravelling neurobiological, behavioural underpinnings these phenomena broad variety conditions. As consequence, there increasing demand health professionals develop...
Although substantial evidence has established that microglia and astrocytes play a key role in the establishment maintenance of persistent pain animal models, glial cells human disorders remains unknown. Here, using novel technology integrated positron emission tomography-magnetic resonance imaging recently developed radioligand (11)C-PBR28, we show increased brain levels translocator protein (TSPO), marker activation, patients with chronic low back pain. As Ala147Thr polymorphism TSPO gene...
The goal of this functional magnetic resonance imaging (fMRI) study was to compare the central effects electroacupuncture at different frequencies with traditional Chinese manual acupuncture. Although not as time-tested acupuncture, does have advantage setting stimulation frequency and intensity objectively quantifiably. Manual 2 Hz 100 Hz, tactile control were carried out acupoint ST-36. Overall, (particularly low frequency) produced more widespread fMRI signal increase than acupuncture...
Central pain augmentation resulting from enhanced excitatory and/or decreased inhibitory neurotransmission is a proposed mechanism underlying the pathophysiology of functional syndromes such as fibromyalgia (FM). Multiple magnetic resonance imaging studies implicate insula region heightened neuronal activity in this condition. Since glutamate (Glu) major cortical neurotransmitter that functions neurotransmission, we undertook study to test our hypothesis increased levels insular Glu would be...
Summary Patterns of intrinsic connectivity within the brain encode intensity clinical pain and predict sustained in patients with chronic low back pain. Neuroimaging studies have suggested presence alterations anatomo-functional properties However, investigation circuitry supporting perception presents significant challenges, particularly when using traditional neuroimaging approaches. While potential markers for included resting connectivity, these cross-sectional not examined sensitivity...
Previous studies have defined low-frequency, spatially consistent networks in resting fMRI data which may reflect functional connectivity. We sought to explore how a complex somatosensory stimulation, acupuncture, influences intrinsic connectivity two of these networks: the default mode network (DMN) and sensorimotor (SMN). analyzed taken before after verum sham acupuncture. Electrocardiography were used infer autonomic modulation through measures heart rate variability (HRV). Probabilistic...
In November 2007, the Society for Acupuncture Research (SAR) held an international symposium to mark 10th anniversary of 1997 NIH Consensus Development Conference on Acupuncture. The presentations revealed considerable maturation field acupuncture research, yet two provocative paradoxes emerged. First, a number well-designed clinical trials have reported that true is superior usual care, but does not significantly outperform sham acupuncture, findings apparently at odds with traditional...
A major impediment to the development of novel treatment strategies for fibromyalgia (FM) is lack an objective marker that reflects spontaneously reported clinical pain in patients with FM. Studies resting-state intrinsic brain connectivity FM have demonstrated increased insular default mode network (DMN), a whose activity during nontask states. Moreover, DMN was associated spontaneous levels. However, as these analyses were cross-sectional nature, they provided no insight into dynamic...
Chronic pain remains a significant challenge for modern health care as its pathologic mechanisms are largely unknown and preclinical animal models suffer from limitations in assessing this complex subjective experience. However, human brain neuroimaging techniques enable the assessment of functional neurochemical alterations patients experiencing chronic how these factors may dynamically change with pharmacologic treatment.To identify clinical action pregabalin, proven analgesic, authors...
Chronic pelvic pain (CPP) is a highly prevalent condition, estimated to affect 15%-20% of women in the United States. Endometriosis often associated with CPP, however, other factors, such as preexisting or concomitant changes central system, might contribute development chronic pain. We applied voxel-based morphometry determine whether CPP and without endometriosis display brain morphology regions known be involved processing. Four subgroups participated: 17 15 6 endometriosis, 23 healthy...
Fibromyalgia (FM) is a poorly understood chronic condition characterized by widespread musculoskeletal pain, fatigue, and cognitive difficulties. While mounting evidence suggests role for neuroinflammation, no study has directly provided of brain glial activation in FM. In this study, we conducted Positron Emission Tomography (PET) using [11C]PBR28, which binds to the translocator protein (TSPO), upregulated activated microglia astrocytes. To enhance statistical power generalizability,...
Chronic low back pain is a common neurological disorder. The periaqueductal gray (PAG) plays key role in the descending modulation of pain. In this study, we investigated brain resting state PAG functional connectivity (FC) differences between patients with chronic (cLBP) or high condition and matched healthy controls (HCs). seed based analysis MR imaging data was performed to investigate difference among maps cLBP HC groups as well within at differing endogenous intensities. Results showed...
Abstract Although the pathophysiology of migraine involves a complex ensemble peripheral and central nervous system changes that remain incompletely understood, activation sensitization trigeminovascular is believed to play major role. However, non-invasive, in vivo neuroimaging studies investigating underlying neural mechanisms trigeminal abnormalities human patients are limited. Here, we studied 60 with (55 females, mean age ± SD: 36.28 11.95 years) 20 age-/sex-matched healthy controls (19...
Acupuncture stimulation elicits deqi, a composite of unique sensations that is essential for clinical efficacy according to traditional Chinese medicine (TCM). There lack adequate experimental data indicate what comprise their prevalence and intensity, relationship acupoints, how they compare with conventional somatosensory or noxious response. The objective this study provide scientific evidence on these issues characterize the nature deqi phenomenon in terms as well uniqueness underlying...
On November 8-9, 2007, the Society for Acupuncture Research (SAR) hosted an international conference to mark tenth anniversary of landmark NIH [National Institutes Health] Consensus Development Conference on Acupuncture. More than 300 acupuncture researchers, practitioners, students, funding agency personnel, and health policy analysts from 20 countries attended SAR meeting held at University Maryland School Medicine, Baltimore, MD. This paper summarizes important invited lectures in area...