A5063257586- Fibromyalgia and Chronic Fatigue Syndrome Research
- Musculoskeletal pain and rehabilitation
- Pain Mechanisms and Treatments
- Stress Responses and Cortisol
- Long-Term Effects of COVID-19
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- S100 Proteins and Annexins
Athinoula A. Martinos Center for Biomedical Imaging
2018-2021
Harvard University
2018-2021
Massachusetts General Hospital
2018-2021
Fibromyalgia (FM) is a poorly understood chronic condition characterized by widespread musculoskeletal pain, fatigue, and cognitive difficulties. While mounting evidence suggests role for neuroinflammation, no study has directly provided of brain glial activation in FM. In this study, we conducted Positron Emission Tomography (PET) using [11C]PBR28, which binds to the translocator protein (TSPO), upregulated activated microglia astrocytes. To enhance statistical power generalizability,...
Gulf War Illness (GWI) is a chronic disorder affecting approximately 30% of the veterans who served in 1991 War. It characterised by constellation symptoms including musculoskeletal pain, cognitive problems and fatigue. The cause GWI not definitively known but exposure to neurotoxicants, prophylactic use pyridostigmine bromide (PB) pills, and/or stressors during deployment have all been suspected play some pathogenic role. Recent animal models suggested that neuroinflammatory mechanisms may...
Chronic pain and mood disorders share common neuroanatomical substrates involving disruption of the reward system. Although increase in negative affect (NA) decrease positive (PA) are well-known factors complicating clinical presentation chronic patients, our understanding mechanisms underlying interaction between PA/NA remains limited. Here, we used a validated task probing behavioral neural responses to monetary rewards losses conjunction with functional magnetic resonance imaging (fMRI)...