A5053860294- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Mind wandering and attention
- Neural and Behavioral Psychology Studies
- Heart Rate Variability and Autonomic Control
- Pain Mechanisms and Treatments
- Mental Health Research Topics
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Mindfulness and Compassion Interventions
- Advanced MRI Techniques and Applications
- Pain Management and Placebo Effect
- Advanced Neuroimaging Techniques and Applications
- Psychosomatic Disorders and Their Treatments
- Tryptophan and brain disorders
- Transcranial Magnetic Stimulation Studies
- Spatial Neglect and Hemispheric Dysfunction
- Bipolar Disorder and Treatment
- Visual perception and processing mechanisms
- Neurological disorders and treatments
- Medical Imaging and Analysis
- Psychological Well-being and Life Satisfaction
- Musculoskeletal pain and rehabilitation
- Intensive Care Unit Cognitive Disorders
- Posttraumatic Stress Disorder Research
Drexel University
2022-2025
Stanford University
2016-2022
Northeastern University
2020-2022
University of Illinois Urbana-Champaign
2022
Harvard University
2015-2021
Massachusetts General Hospital
2015-2021
Athinoula A. Martinos Center for Biomedical Imaging
2016-2019
Stanford Medicine
2017-2018
University of Toronto
2011-2017
University Health Network
2010-2017
Significance The mind easily wanders away from mundane tasks, but pain is presumed to automatically capture attention. We demonstrate that individuals differ in how often their minds spontaneously wander and these differences are associated with the disruptive effect of on cognitive performance. Brain–behavior relationships underscore individual differences. When people’s pain, there increased activations default mode network (DMN) strong interactions between DMN periaqueductal gray (PAG),...
Rumination is a form of thought characterized by repetitive focus on discomforting emotions or stimuli. In chronic pain disorders, rumination can impede treatment efficacy. The brain mechanisms underlying about are not understood. Interestingly, link between and functional connectivity (FC) the brain's default mode network (DMN) has been identified within context mood disorders. We, others, have also found DMN dysfunction in populations. medial prefrontal cortex (mPFC) key node that...
Human attention is intrinsically dynamic, with focus continuously shifting between elements of the external world and internal, self-generated thoughts. Communication within large-scale brain networks also fluctuates spontaneously from moment to moment. However, behavioral relevance dynamic functional connectivity possible link attentional state shifts unknown. We used a unique approach examine whether network dynamics reflect spontaneous fluctuations in moment-to-moment variability,...
ABSTRACT Trait mindfulness refers to one's disposition or tendency pay attention their experiences in the present moment, a non‐judgmental and accepting way. has been robustly associated with positive mental health outcomes, but its neural underpinnings are poorly understood. Prior resting‐state fMRI studies have trait within‐ between‐network connectivity of default‐mode (DMN), fronto‐parietal (FPN), salience networks. However, it is unclear how generalizable findings are, they relate...
Neuroimaging studies have demonstrated that the right temporoparietal junction (TPJ) is activated during detection of salient stimuli, including pain, in sensory environment. Right TPJ damage more often produces spatial neglect than left damage. We recently reported a lateralized system white matter connectivity TPJ. However, lateralization intrinsic functional task/stimuli-independent state has not been fully characterized. Here we used resting-state MRI healthy humans to compare and with...
The brain's default mode network (DMN) is highly active during wakeful rest when people are not overtly engaged with a sensory stimulus or externally oriented task. In multiple contexts, increased spontaneous DMN activity has been associated self-reported episodes of mind-wandering, thoughts that unrelated to the present environment. Mind-wandering characterizes much waking life and often error-prone, variable behavior. However, also reliably stable, rather than variable, We aimed address...
Evidence for intrinsic functional connectivity (FC) within the human brain is largely from neuroimaging studies of hemodynamic activity. Data are lacking anatomically precise electrophysiological recordings in most widely studied nodes networks. Here we used a combination fMRI and electrocorticography (ECoG) five neurosurgical patients with electrodes canonical “default” (medial prefrontal posteromedial cortex), “dorsal attention” (frontal eye fields superior parietal lobule),...
Abstract The periaqueductal gray matter (PAG) is a key brain region of the descending pain modulation pathway. It also involved in cardiovascular functions, anxiety, and fear; however, little known about PAG subdivisions humans. aims this study were to use resting‐state fMRI‐based functional connectivity (FC) parcellate human determine FC its subregions. To do this, we acquired fMRI scans from 79 healthy subjects (1) used data‐driven method PAG, (2) predefined seeds subregions evaluate whole...
Neuroimaging evidence suggests that the default mode network (DMN) exhibits antagonistic activity with dorsal attention (DAN) and salience (SN) networks. Here we use human intracranial electroencephalography to investigate behavioral relevance of fine-grained dynamics within between these The three networks show dissociable profiles task-evoked electrophysiological activity, best captured in high-frequency broadband (HFB; 70-170 Hz) range. On order hundreds milliseconds, HFB responses peak...
In cognitive neuroscience, focus is commonly placed on associating brain function with changes in objectively measured external stimuli or actively generated processes. everyday life, however, many forms of processes are initiated spontaneously, without an individual’s active effort and explicit manipulation behavioral state. Recently, there has been increased emphasis, especially functional neuroimaging research, spontaneous correlated activity among spatially segregated regions (intrinsic...
Abstract Neural substrates of “mind wandering” have been widely reported, yet experiments varied in their contexts and definitions this psychological phenomenon, limiting generalizability. We aimed to develop test the generalizability, specificity, clinical relevance a functional brain network-based marker for well-defined feature mind wandering—stimulus-independent, task-unrelated thought (SITUT). Combining MRI (fMRI) with online experience sampling healthy adults, we defined...
The temporoparietal junction (TPJ) is a key node in the brain's ventral attention network (VAN) that involved spatial awareness and detection of salient sensory stimuli, including pain. anatomical basis this network's right-lateralized organization poorly understood. Here we used diffusion-weighted MRI probabilistic tractography to compare strength white matter connections emanating from right versus left TPJ target regions both hemispheres. Symmetry structural connectivity was evaluated for...