A5100324060- Epilepsy research and treatment
- Neurological disorders and treatments
- Neuroscience and Neuropharmacology Research
- Radiomics and Machine Learning in Medical Imaging
- Functional Brain Connectivity Studies
- Pharmacological Effects and Toxicity Studies
- EEG and Brain-Computer Interfaces
- Parkinson's Disease Mechanisms and Treatments
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Botulinum Toxin and Related Neurological Disorders
- Fetal and Pediatric Neurological Disorders
- Advanced Neuroimaging Techniques and Applications
- Glioma Diagnosis and Treatment
- Neonatal and fetal brain pathology
- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Genetic Neurodegenerative Diseases
- Medical Imaging Techniques and Applications
- Sexual function and dysfunction studies
- Advanced X-ray and CT Imaging
- Dementia and Cognitive Impairment Research
- Regulation of Appetite and Obesity
- Sleep and Wakefulness Research
- Cerebral Venous Sinus Thrombosis
Beijing Tian Tan Hospital
2016-2025
Capital Medical University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Beijing Anzhen Hospital
2019-2025
Peking Union Medical College Hospital
2025
University at Albany, State University of New York
2024-2025
Yixing People's Hospital
2025
Jiangsu University
2025
Beijing Institute of Neurosurgery
2013-2024
Chinese PLA General Hospital
2011-2024
Importance A leading cause of surgically remediable, drug-resistant focal epilepsy is cortical dysplasia (FCD). FCD challenging to visualize and often considered magnetic resonance imaging (MRI) negative. Existing automated methods for detection are limited by high numbers false-positive predictions, hampering their clinical utility. Objective To evaluate the efficacy interpretability graph neural networks in automatically detecting lesions on MRI scans. Design, Setting, Participants In this...
Deep brain stimulation (DBS) of the ventral intermediate nucleus thalamus (VIM) has proven to be efficacious in treatment essential tremor (ET). The authors report on long-term follow-up a series patients treated at 1 institution by neurosurgeon.Thirty-four with ET received unilateral or bilateral VIM DBS. and handwriting components Fahn-Tolosa-Marin clinical rating scale were assessed pre- postoperatively. Visual analog scores for overall patient satisfaction control recorded. Stimulation...
Mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE-HS) is the most common type of focal epilepsy. The present study aimed to explore expression and functions exosomal microRNAs in mTLE-HS. A total 50 were found be differentially expressed mTLE-HS compared healthy controls. Among them, 2 increased 48 decreased. 6 significant candidate (miR-3613-5p, miR-4668-5p, miR-8071, miR-197-5p, miR-4322, miR-6781-5p ) exosome validated. bioinformatics analysis showed that potential target...
Summary Objective Focal cortical dysplasia ( FCD ) is a major pathology in patients undergoing surgical resection to treat pharmacoresistant epilepsy. Magnetic resonance imaging MRI postprocessing methods may provide essential help for detection of . In this study, we utilized surface‐based morphometry and machine learning automated lesion mixed cohort with type II from 3 different epilepsy centers. Methods Sixty‐one histologically proven were included the study. The had been evaluated at...
Neuroimaging evidence suggests that the default mode network (DMN) exhibits antagonistic activity with dorsal attention (DAN) and salience (SN) networks. Here we use human intracranial electroencephalography to investigate behavioral relevance of fine-grained dynamics within between these The three networks show dissociable profiles task-evoked electrophysiological activity, best captured in high-frequency broadband (HFB; 70-170 Hz) range. On order hundreds milliseconds, HFB responses peak...
Drug-resistant focal epilepsy is often caused by cortical dysplasias (FCDs). The distribution of these lesions across the cerebral cortex and impact lesion location on clinical presentation surgical outcome are largely unknown. We created a neuroimaging cohort patients with individually mapped FCDs to determine factors associated predictors postsurgical outcome.
Abstract One outstanding challenge for machine learning in diagnostic biomedical imaging is algorithm interpretability. A key application the identification of subtle epileptogenic focal cortical dysplasias (FCDs) from structural MRI. FCDs are difficult to visualize on MRI but often amenable surgical resection. We aimed develop an open-source, interpretable, surface-based machine-learning automatically identify heterogeneous data epilepsy surgery centres worldwide. The Multi-centre Epilepsy...
The purpose of this study was to investigate the protective mechanism leptin-mediated metabolic recovery against cerebral injury after ischemia and reperfusion. We determined neurologic deficit score, extent brain edema, infarct volume histopathologic alterations changes in glucose uptake were also observed. Moreover, levels lactate dehydrogenase (LDH), lactic acid, pyruvate, ATP tissue detected. Leptin serum To further define leptin-induced neuroprotective signaling pathways, we examined...
Abstract At least 50% of patients with tuberous sclerosis complex present intractable epilepsy; for these patients, resective surgery is a treatment option. Here, we report nationwide multicentre retrospective study and analyse the long-term seizure neuropsychological outcomes epilepsy in complex. There were 364 who underwent study. Patients’ clinical data, postoperative at 1-, 4-, 10-year follow-ups, preoperative intelligence quotients, quality life 1-year follow-up collected. The patients’...
Abstract Objective Temporal lobe epilepsy is a common form of that might be amenable to surgery. However, magnetic resonance imaging (MRI)‐negative hippocampal sclerosis (HS) can hamper early diagnosis and surgical intervention for patients in clinical practice, resulting disease progression. Our aim was automatically detect evaluate the structural alterations HS. Methods Eighty with pharmacoresistant histologically proven HS 80 healthy controls were included study. Two automated classifiers...
Abstract Objective To develop and validate a model to predict seizure freedom in children undergoing cerebral hemispheric surgery for the treatment of drug‐resistant epilepsy. Methods We analyzed 1267 surgeries performed pediatric participants across 32 centers 12 countries identify predictors at 3 months after surgery. A multivariate logistic regression was developed based on 70% dataset (training set) validated 30% (validation set). Missing data were handled using multiple imputation...
Dystonia is one of the most challenging movement disorders to treat. Medications and surgeries are two methods control dystonic symptoms. For patients with dystonia in whom symptoms inadequately controlled pharmacologic measures, use deep brain stimulation (DBS) can improve enhance functional capacity. The best candidate for DBS believed be primary generalized dystonia, especially DYT-1 type. Here, we report 9 cases secondary explore feasibility, indications complications treatment...
Significance Direct electrical stimulation and intracranial recordings from the human brain during cognitive experiments revealed unique information about temporal order of signal processing within across intrinsic resting-state networks. Pairs regions located same networks communicate faster coactivate closer in time than those different
This study was undertaken to determine whether the vertical parasagittal approach or lateral peri-insular/peri-Sylvian hemispheric surgery is superior technique in achieving long-term seizure freedom. We conducted a post hoc subgroup analysis of HOPS (Hemispheric Surgery Outcome Prediction Scale) study, an international, multicenter, retrospective cohort that identified predictors freedom through logistic regression modeling. Only patients undergoing parasagittal, peri-insular/peri-Sylvian,...