A5008238182- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Memory and Neural Mechanisms
- Memory Processes and Influences
- Functional Brain Connectivity Studies
- Visual perception and processing mechanisms
- Multisensory perception and integration
- Railway Engineering and Dynamics
- Neural Networks and Applications
- EEG and Brain-Computer Interfaces
- Face Recognition and Perception
- Child and Animal Learning Development
- Sleep and Wakefulness Research
- Deception detection and forensic psychology
- Mechanical stress and fatigue analysis
- Neuroscience and Neuropharmacology Research
- Transcranial Magnetic Stimulation Studies
- Mental Health Research Topics
- Neuroscience of respiration and sleep
- Neuroendocrine regulation and behavior
- Olfactory and Sensory Function Studies
- Spatial Cognition and Navigation
- Neurotransmitter Receptor Influence on Behavior
- Obsessive-Compulsive Spectrum Disorders
- Data Visualization and Analytics
University of Pennsylvania
2008-2024
Swansea University
2014-2023
Columbia University
2019-2023
Philadelphia University
2008-2017
Instituto Tecnológico de Santo Domingo
2009
Instituto de Desarrollo Tecnológico para la Industria Química
2009
Indiana University Bloomington
2005
The brain's sensitivity to unexpected outcomes plays a fundamental role in an organism's ability adapt and learn new behaviors. Emerging research suggests that midbrain dopaminergic neurons encode these outcomes. We used microelectrode recordings during deep brain stimulation surgery study neuronal activity the human substantia nigra (SN) while patients with Parkinson's disease engaged probabilistic learning task motivated by virtual financial rewards. Based on model of participants'...
The subthalamic nucleus (STN), which receives excitatory inputs from the cortex and has direct connections with inhibitory pathways of basal ganglia, is well positioned to efficiently mediate action selection. Here, we use microelectrode recordings captured during deep brain stimulation surgery as participants engage in a decision task examine role human STN We demonstrate that spiking activity increases when level degree conflict. These data implicate an important mediator selection processes.
Classification of stimuli into categories (such as 'old' and 'new' in tests recognition memory or 'present' versus 'absent' signal detection tasks) requires the mapping internal signals to discrete responses. Introspective judgements about a given choice response are regularly employed research, legal clinical settings an effort measure that is thought be basis classification decision. Correlations between introspective task performance suggest such ratings often do convey information states...
Objective. Although interest in using electroencephalogram (EEG) activity for subject identification has grown recent years, the state of art still lacks a comprehensive exploration discriminant information within it. This work aims to fill this gap, and particular, it focuses on time-frequency representation EEG. Approach. We executed qualitative quantitative analyses six publicly available data sets following sequential experimentation approach. approach was divided three blocks analysing...
[Correction Notice: An Erratum for this article was reported in Vol 148(4) of Journal Experimental Psychology: General (see record 2019-19962-009). In article, the second sentence paragraph author note omitted additional grant information and should appear instead as follows: This work supported by DARPA Restoring Active Memory (RAM) program (Cooperative Agreement N66001-14-2-4032) National Institutes Health (Grant MH055687).] Whereas numerous findings support a distinction between episodic...
A wealth of evidence from behavioural, neuropsychological and neuroimaging research supports the view that face recognition is reliant upon a domain-specific network does not process words. In contrast, recent many-to-many model visual posits brain areas involved in word are functionally integrated. Developmental prosopagnosia (DP) characterised by severe deficits faces, which predicts should negatively affect recognition. Alternatively, accounts suggest impairments processing need go hand...
Scientific advances across a range of disciplines hinge on the ability to make inferences about unobservable theoretical entities basis empirical data patterns. Accurate rely both discovering valid, replicable patterns and accurately interpreting those in terms their implications for constructs. The replication crisis science has led widespread efforts improve reliability research findings, but comparatively little attention been devoted validity based findings. Using an example from...
In modern railway industry the simulation of behaviour vehicles has become an important design method during last years. Modern packages offer modelling elements that are highly adapted for standard and unusual scenarios. A specific application case is a vehicle travelling through switch. It makes high demands on software due to inconvenient needed: changing rail profiles blade in crossing vee area as well guard with its additional contact at back wheel. The article gives overview over state...
DUAL PROCESS MODELS OF RECOGNITION MEMORY PROPOSE TWO DISTINCT ROUTES FOR RECOGNIZING A FACE: recollection and familiarity. Recollection is characterized by the remembering of some contextual detail from a previous encounter with face whereas familiarity feeling finding familiar without any details. The Remember/Know (R/K) paradigm thought to index relative contributions recognition performance. Despite researchers measuring deficits in developmental prosopagnosia (DP) through variety...
Summary Spatial navigation relies on neural systems that encode information about places, distances, and directions in relation to the external world or relative navigating organism. Since proposal of cognitive maps, neuroscience has focused allocentric (world-referenced) representations including place, grid, head-direction cells. Here, using single-neuron recordings during virtual navigation, we identify “anchor cells” human brain as a code for egocentric (self-centered) spatial maps:...
The Penn Electrophysiology of Encoding and Retrieval Study (PEERS) aimed to characterize the behavioral electrophysiological (EEG) correlates memory encoding retrieval in highly practiced individuals. Across five PEERS experiments, 300+ subjects contributed more than 7,000 testing sessions with recorded EEG data. Here we tell story PEERS: its genesis, evolution, major findings, lessons it taught us about taking a big scientific approach studying human brain. (PsycInfo Database Record (c)...
Multi-body simulation is a key method for design, homologation and research of railed vehicles all kind. Not only the "classic" assessment rail-to-wheel forces running stability but also many other common advanced tasks can today be handled by multi-body simulation. This paper gives an overview state art different fields application, lifecycle steps user groups in railway industry, along with some examples basic applications current topics.
The human substantia nigra (SN) is thought to consist of two functionally distinct neuronal populations--dopaminergic (DA) neurons in the pars compacta subregion and GABA-ergic reticulata subregion. However, a functional dissociation between these populations has not previously been demonstrated awake human. Here we obtained microelectrode recordings from SN patients undergoing deep brain stimulation (DBS) surgery for Parkinson's disease as they performed two-alternative reinforcement...
Human cognition exhibits a striking degree of variability: Sometimes we rapidly forge new associations whereas at other times information simply does not stick. Correlations between neural activity during encoding and subsequent retrieval performance have implicated such "subsequent memory effects" (SMEs) as important for understanding the basis formation. Uncontrolled variability in external factors that also predict performance, however, confounds interpretation these effects. By...
The authors investigated spatial, temporal, and attentional manipulations in a short-term repetition priming paradigm. Brief primes produced strong preference to choose the primed alternative, whereas long had opposite effect. However, 2nd brief presentation of prime for word despite total duration. These surprising results are explained by computational model that posits offsetting components source confusion (prime features confused with target features) discounting (evidence from is...