A5010149983- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Fetal and Pediatric Neurological Disorders
- Dementia and Cognitive Impairment Research
- Vector-borne infectious diseases
- Memory and Neural Mechanisms
- Alzheimer's disease research and treatments
- Advanced MRI Techniques and Applications
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Psychosomatic Disorders and Their Treatments
- Neuroscience and Neuropharmacology Research
- Memory Processes and Influences
- Multiple Sclerosis Research Studies
- Sleep and Wakefulness Research
- Decision-Making and Behavioral Economics
- Robotics and Automated Systems
- Face and Expression Recognition
- Neuroscience and Music Perception
- Cerebrospinal fluid and hydrocephalus
- Child and Animal Learning Development
- Frailty in Older Adults
- Neurobiology of Language and Bilingualism
- Schizophrenia research and treatment
- Traumatic Brain Injury Research
- Neural dynamics and brain function
University of Pennsylvania
2024
Johns Hopkins Medicine
2018-2023
Johns Hopkins University
2018-2023
Temple University
2015-2018
Temple College
2016-2017
Philadelphia University
2016
Abstract Objectives: The extended face network contains clusters of neurons that perform distinct functions on facial stimuli. Regions in the posterior ventral visual stream appear to basic perceptual faces, while more anterior regions, such as temporal lobe and amygdala, function link mnemonic affective information faces. Anterior regions are interconnected by a long-range white matter tracts; however, it is not known if variation connectivity these pathways explains cognitive performance....
Episodic memory undergoes dramatic improvement in early childhood; the reason for this is poorly understood. In adults, episodic relies on a distributed neural network. Key brain regions that supporting these processes include hippocampus, portions of parietal cortex, and prefrontal each which shows different developmental profiles. Here we asked whether differences axonal pathways connecting may account robust gains young children. Using diffusion weighted imaging, examined white matter...
The Penn Electrophysiology of Encoding and Retrieval Study (PEERS) aimed to characterize the behavioral electrophysiological (EEG) correlates memory encoding retrieval in highly practiced individuals. Across five PEERS experiments, 300+ subjects contributed more than 7,000 testing sessions with recorded EEG data. Here we tell story PEERS: its genesis, evolution, major findings, lessons it taught us about taking a big scientific approach studying human brain. (PsycInfo Database Record (c)...
Each day, we make hundreds of decisions. In some instances, these decisions are guided by our innate needs; in other instances they memory. Probabilistic reversal learning tasks exemplify the close relationship between decision making and memory, as subjects exposed to repeated pairings a stimulus choice with reward or punishment outcome. After stimulus-outcome associations have been learned, associated contingencies reversed, participants not immediately aware this reversal. Individual...
Lyme disease is the most common vector-borne infectious in United States. Post-treatment (PTLD) a condition affecting 10-20% of patients which symptoms persist despite antibiotic treatment. Cognitive complaints are among those with PTLD, suggesting that brain changes associated course illness. However, there has been paucity evidence to explain cognitive difficulties expressed by PTLD. This study administered working memory task carefully screened group 12 well-characterized PTLD and 18...
Diffusion tensor imaging (DTI) studies suggest that reduced fractional anisotropy (FA) in the inferior longitudinal fasciculus (ILF) and superior (SLF) occurs among schizophrenia patients those at risk for psychosis. Nevertheless, there is a dearth of knowledge investigating white matter fibre pathways non-help-seeking individuals who endorse attenuated positive psychotic symptoms (APPS) across range mental disorders. The aim current study was to determine if alterations ILF SLF...
The Penn Electrophysiology of Encoding and Retrieval Study (PEERS) aimed to characterize the behavioral electrophysiological (EEG) correlates memory encoding retrieval in highly practiced individuals. Across five PEERS experiments, 300+ subjects contributed more than 7,000 90 minute testing sessions with recorded EEG data. Here we tell story PEERS: it's genesis, evolution, major findings, lessons it taught us about taking a big science approach study human brain.
In this study, we examined the independent contributions of structural and functional connectivity markers to individual differences in episodic memory performance 107 cognitively normal older adults from BIOCARD study. Structural connectivity, defined by diffusion tensor imaging (DTI) measure radial diffusivity (RD), was obtained two medial temporal lobe white matter tracts: fornix hippocampal cingulum, while were derived network-based resting state magnetic resonance (rsfMRI) five...
Introduction The accumulation of neurofibrillary tau tangles, a neuropathological hallmark Alzheimer’s disease (AD), occurs in medial temporal lobe (MTL) regions early the process, with some earliest deposits localized to subregions entorhinal cortex. Although functional specialization cortex has been reported, few studies have considered associations accumulation. Methods In this study, stepwise linear regressions were used examine contributions regional burden specific MTL subregions, as...
Abstract There is a growing consensus that social cognition and behavior emerge from interactions across distributed regions of the “social brain”. Social neuroscience has traditionally focused its attention on functional response properties these gray matter networks neglected vital role white (WM) connections in establishing such their functions. In this article, we conduct comprehensive review prior research structural connectivity highlight importance literature clarifying brain...
Abstract Lyme disease is the most common vector-borne infectious in United States. Post-treatment (PTLD) a condition affecting 10-20% of patients which symptoms persist despite antibiotic treatment. Cognitive complaints are among those with PTLD, suggesting that brain changes associated course illness. However, there has been paucity evidence to explain cognitive difficulties expressed by PTLD. This study administered working memory task carefully screened group 12 well-characterized PTLD...
Abstract Lyme disease (LD) is a tick-borne infection due to the bacteria Borrelia burgdorferi . After antibiotic treatment, 10-20% of patients develop post-treatment (PTLD). Neurological symptoms are commonly reported in PTLD. This case-control study tested hypothesis that brain changes occur LD and related clinical outcomes. A working memory task was administered during functional MRI (fMRI), conjunction with cognitive assessments health surveys, examine function outcomes people acute...
Abstract Background Mounting evidence indicates that tau accumulation in the entorhinal cortex (EC) occurs early course of Alzheimer’s disease (AD). Recent advances automated segmentation methods allow for investigation smaller regions medial temporal lobes (MTL), including subregions EC. This study examined deposition relation to individual differences cognition among older adults, assessing whether MTL explained a greater proportion variance cognition, when compared standard labeling...