A5015465152- Pain Management and Placebo Effect
- Pain Mechanisms and Treatments
- Musculoskeletal pain and rehabilitation
- Health, Medicine and Society
- Complementary and Alternative Medicine Studies
- Pain Management and Opioid Use
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Opioid Use Disorder Treatment
- Pediatric Pain Management Techniques
- Connective tissue disorders research
- Psychosomatic Disorders and Their Treatments
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Botulinum Toxin and Related Neurological Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Homelessness and Social Issues
- Empathy and Medical Education
- Anesthesia and Pain Management
- Food Security and Health in Diverse Populations
- Acupuncture Treatment Research Studies
- Mental Health Research Topics
- Neural and Behavioral Psychology Studies
- Healthcare Systems and Practices
- Maternal and Perinatal Health Interventions
- Mind wandering and attention
- Neurology and Historical Studies
University of Lausanne
2018-2025
University Hospital of Lausanne
2016-2025
The Sense Innovation and Research Center
2022-2024
National Center for Complementary and Integrative Health
2022-2024
University of Fribourg
2021-2022
Integrative Medicine Institute
2022
Harvard University
2012-2019
Warneford Hospital
2010-2018
University of Oxford
2009-2018
Wellcome Centre for Integrative Neuroimaging
2009-2018
The dominant theories of human placebo effects rely on a notion that consciously perceptible cues, such as verbal information or distinct stimuli in classical conditioning, provide signals activate effects. However, growing evidence suggest behavior can be triggered by presented outside conscious awareness. Here, we performed two experiments which the responses to thermal pain were assessed. first experiment assessed whether conditioning paradigm, using clearly visible cues for high and low...
Control interventions (often called "sham," "placebo," or "attention controls") are essential for studying the efficacy mechanism of physical, psychological, and self-management in clinical trials. This article presents core recommendations designing, conducting, reporting control to establish a quality standard non-pharmacological intervention research. A framework additional considerations supports researchers' decision making this context. We also provide checklist enhance research...
Relief fits the definition of a reward. Unlike other reward types pleasantness relief depends on violation negative expectation, yet this has not been investigated using neuroimaging approaches. We hypothesized that degree expectation state (dread) and trait (pessimism) sensitivity. Of brain regions are involved in mediating pleasure, nucleus accumbens also signals unexpected positive prediction error. activity reflects level subsequent pleasant relief. Using fMRI two purpose-made tasks, we...
Summary When moderate pain was presented in a context of intense pain, it induced relief and ‘hedonic flip’ such that reported as pleasant. Context can influence the experience any event. For instance, thought “it could be worse” improve feelings towards present misfortune. In this study we measured hedonic feelings, skin conductance, brain activation patterns 16 healthy volunteers who experienced two different contexts. “relative context,” represented best outcome, since alternative outcome...
Objective While patients with fibromyalgia (FM) are known to exhibit hyperalgesia, the central mechanisms contributing this altered pain processing not fully understood. This study was undertaken investigate potential dysregulation of neural circuitry underlying cognitive and hedonic aspects subjective experience pain, such as anticipation relief. Methods Thirty‐one FM 14 controls underwent functional magnetic resonance imaging, while receiving cuff pressure stimuli on leg calibrated elicit...
Fibromyalgia (FM) is a chronic, common pain disorder characterized by hyperalgesia. A key mechanism which cognitive-behavioral therapy (CBT) fosters improvement in outcomes via reductions hyperalgesia and pain-related catastrophizing, dysfunctional set of cognitive-emotional processes. However, the neural underpinnings these CBT effects are unclear. Our aim was to assess CBT's on brain circuitry underlying FM patients, explore role treatment-associated reduction catastrophizing as...
Although self-report pain ratings are the gold standard in clinical assessment, they inherently subjective nature and significantly influenced by multidimensional contextual variables. objective biomarkers for could substantially aid diagnosis development of novel therapies, reliable markers have been elusive. In this study, individualized physical maneuvers were used to exacerbate patients with chronic low back (N = 53), thereby experimentally producing lower higher states. Multivariate...
The tendency to interpret ambiguous everyday situations in a relatively negative manner (negative interpretation bias) is central cognitive models of depression. Limited tools are available measure this bias, either experimentally or the clinic. This study aimed develop pragmatic bias using an scenarios test relevant depressed mood (the AST-D). In Study 1, after pilot phase (N = 53), AST-D was presented via web-based survey 208). Participants imagined and rated each scenario. As predicted,...
Abstract Diagnosing hypermobile Ehlers–Danlos syndrome (hEDS) remains challenging, despite new 2017 criteria. Patients not fulfilling these criteria are considered to have spectrum disorder (HSD). Our first aim was evaluate whether patients hEDS were more severely affected and had higher prevalence of extra-articular manifestations than HSD. Second compare their outcome after coordinated physical therapy. hEDS/HSD included in this real-life prospective cohort (November 2017/April 2019). They...
Objective. To ascertain whether a small sample of patients with chronic pelvic pain experienced any pain-related cognitions in the form mental images.
Therapy with mental images is prevalent in the field of chronic pain, and this has been case for centuries. Yet few recent advances cognitive behavioural understanding spontaneous (i.e. intrusive) imagery have translated to field. Such include as a component psychopathological process, an emotional amplifier therapeutic target its own right. Hence very little known about contents, prevalence impact context pain. This article discusses evidence favour being potentially important part...
Implementing a recall paradigm without hypnosis, we use functional MRI (fMRI) to explore and compare nociceptive centrally-driven pain experiences. We posit that trace of recent event can be used create sensory-re-experiencing qualified in terms intensity vividness. Fifteen healthy volunteers received three levels thermal stimuli (warm, low high pain) subsequently were asked then rate this experience. Neuroimaging results reveal recalling previous sensory experience activates an extensive...
Abstract In randomized controlled trials, medication side effects may lead to beliefs that one is receiving the active intervention and enhance treatment responses, thereby increasing drug–placebo differences. We tested these hypotheses with an experimental double-blind trial of a nonsteroidal anti-inflammatory drug without addition atropine induce effects. One hundred healthy volunteers were told they would be either combined analgesics might produce dry mouth or inert placebos. reality,...
Abstract Impairments in emotion regulation are thought to have a key role the pathogenesis of anxiety disorders, but neurobiological underpinnings contributing vulnerability remain poorly understood. It has been long-held view that exaggerated fear is linked hyperresponsivity limbic brain areas and impaired recruitment prefrontal control. However, increasing evidence suggests prefrontal–cortical networks hyperactive during threat processing disorders. This study directly explored...
Pain is regulated endogenously through both opioid and non-opioid mechanisms. We hypothesized that two novel pain modulation tasks, one drawing on context/expectations using voluntary reappraisal, would show differing levels of dependence. Specifically, we expected naloxone block context-related analgesia, whereas mental imagery-based reappraisal be opioid-independent. A double-blind, placebo-controlled intravenous versus saline crossover design was used. Twenty healthy volunteers completed...
Exploring psychophysiological changes during hypnosis can help to better understand the nature and extent of hypnotic phenomenon by characterizing its influence on autonomic nervous system (ANS), in addition central brain effects. Hypnosis is thought induce a relaxation response, yet studies using objective measures alongside protocols show various results. We review this literature clarify effects indices ANS activity more specifically stress/relaxation such as heart rate variability...
AIMS: The literature from Canada, the UK and USA reports health inequities among people experiencing homelessness; however little is known about this population’s in Switzerland. Our study first to comprehensively assess needs, expectations experiences of homelessness METHODS: We describe French-speaking Switzerland, using both quantitative qualitative methods. From May August 2022, 123 completed questionnaires experiences. Recruitment took place 10 homeless-serving institutions across four...
Palliative care patients facing the end of their life often experience severe symptoms and seek complementary therapies for relief improved well-being. Clinical hypnosis is a promising mind-body therapy in palliative settings, benefiting both relatives. Nevertheless, access at end-of-life can be limited due to symptom severity restricted mobility. This study aimed assess feasibility acceptability home-based intervention alleviate relatives enhance coping resources. A mixed-method...