A5016462581- Pain Management and Placebo Effect
- Pain Mechanisms and Treatments
- Neuroscience, Education and Cognitive Function
- Empathy and Medical Education
- Complementary and Alternative Medicine Studies
- Botulinum Toxin and Related Neurological Disorders
- Neurology and Historical Studies
- Acupuncture Treatment Research Studies
- Neurological disorders and treatments
- EEG and Brain-Computer Interfaces
- Psychosomatic Disorders and Their Treatments
- Musculoskeletal pain and rehabilitation
- Mental Health and Psychiatry
- Neural and Behavioral Psychology Studies
- Parkinson's Disease Mechanisms and Treatments
- Mindfulness and Compassion Interventions
- Neural dynamics and brain function
- Delphi Technique in Research
- Functional Brain Connectivity Studies
- Psychotherapy Techniques and Applications
- Patient-Provider Communication in Healthcare
- Health Systems, Economic Evaluations, Quality of Life
- Neuroscience and Neural Engineering
- Migraine and Headache Studies
- Neuroethics, Human Enhancement, Biomedical Innovations
University of Turin
2016-2025
Ospedale San Giuseppe
2024
IRCCS Istituto Auxologico Italiano
2024
Neuroscience Institute
2010-2017
Google (United States)
2011
Elisa (Finland)
2011
This Perspective adapts the ViolEx Model, a framework validated in several clinical conditions, to better understand role of expectations recovery and/or maintenance musculoskeletal (MSK) pain. Here, particular attention is given condition which dysfunctional are maintained despite no longer being supported by confirmatory evidence (i.e., belief-lifting arm leads permanent tendon damage; evidence-after patient lifts damage occurs). While Model suggests that cognitive immunization strategies...
Control interventions (often called "sham," "placebo," or "attention controls") are essential for studying the efficacy mechanism of physical, psychological, and self-management in clinical trials. This article presents core recommendations designing, conducting, reporting control to establish a quality standard non-pharmacological intervention research. A framework additional considerations supports researchers' decision making this context. We also provide checklist enhance research...
Objective Emerging literature suggests contextual factors are important components of therapeutic encounters and may substantially influence clinical outcomes a treatment intervention. At present, single consensus definition factors, which is universal across all health-related conditions lacking. The objective this study was to create better refine concept for clinicians researchers. Design used multi-stage virtual Nominal Group Technique (vNGT) rank factor definitions. group techniques...
Abstract Placebos have been shown to induce powerful effects in a variety of medical conditions, such as pain and movement disorders, well increase physical performance endurance healthy subjects. Here we investigated the an ergogenic placebo on quadriceps muscle, which is responsible for extension leg relative thigh. In first experiment, was administered along with suggestion that it caffeine at high dose. This resulted significant mean muscle work across subjects, which, however, not...
In placebo-controlled trials, the placebo component of treatments is usually assessed by simulating a therapy through administration dummy treatment (placebo) in order to eliminate specific effects therapy. Recently, radically different approach analysis responses has been implemented which are without groups. To do this, (psychological) eliminated conducting hidden (unexpected) administrations active treatment. Compelling experimental evidence now shows that when psychological therapies...
Key points We analysed the placebo response at single‐neuron level in thalamus of Parkinson patients to see differences between first‐time administration and after pharmacological pre‐conditioning. When was given for first time, it induced neither clinical improvement, as assessed through muscle rigidity reduction wrist, nor neuronal changes thalamic neurons. However, if two, three or four prior administrations an anti‐Parkinson drug, apomorphine, produced both responses. Both magnitude...
Abstract Background and aim Despite recent publications, practitioners remain unfamiliar with the current terminology related to placebo nocebo phenomena observed in clinical trials practice, nor factors that modulate them. To cover gap, European Headache Federation appointed a panel of experts clarify terms associated use trials. Methods The working group identified relevant questions agreed upon recommendations. Because no data were required answer questions, GRADE approach was not...
Pain management in elderly people with cognitive impairment poses special challenges, due to difficulties pain assessment and specific neurodegenerative changes along pathways. Most studies have concentrated on Alzheimer's disease (AD) patients, whom some contrasting findings been found. For example, while psychophysical data suggest a selective blunting of the affective dimension pain, pain-related fMRI signal increases also described. Few reported patients frontotemporal dementia (FTD). By...
Abstract Background The exact role of expectation in conditioned analgesia is still elusive as it not clear whether conditioning an automatic process or rather cognitively mediated. This study aimed at understanding the explicit verbal information analgesia. Methods Two groups healthy subjects received a procedure whereby two visual cues were paired with increase and decrease stimulus intensity. In ‘conditioning/verbal information’ group ( VER ), informed about meaning cues, whereas no was...
Abstract Placebos have been found to affect a number of pathological processes and physiological functions through expectations clinical improvement. Recently, the study placebo effect has moved from physical performance setting, wherein placebos can boost by increasing muscle work decreasing perceived exertion. However, nothing is known about neurobiological underpinnings this phenomenon. Here we show for first time that placebo, which subjects believed be endurance‐increasing caffeine,...
Expectation is an important mechanism underlying placebo response. Here, we analysed expectation of hypoalgesia and nocebo hyperalgesia by using, for the first time, contingent negative variation (CNV), also known as expectancy wave.Subjects were presented a green or red cue followed train either non painful electrical stimuli, expected after cue. In experiment 1, was reinforced using conditioning procedure whereby cues paired with respectively (acquisition). second session (test) intensity...
Background Noninvasive physical management is often prescribed for headache and neck pain. Systematic reviews, however, indicate that the evidence of its efficacy limited. Our aim was to evaluate effectiveness a workplace educational program in reducing neck/shoulder Methodology/Principal Findings Cluster-randomized controlled trial. All municipal workers City Turin, Italy, were invited participate. Those who agreed randomly assigned, according their departments, intervention group (IG) or...
In spite of the large number studies on schizophrenia, a full understanding its core pathology still eludes us. The application nonlinear theory electroencephalography (EEG) analysis provides an interesting tool to differentiate between physiologic conditions (e.g., resting state and mathematical task) normal pathologic brain activities. aim present study was investigate EEG activity in patients with schizophrenia.We recorded 19-lead EEGs stable schizophrenia healthy controls under 4...