A5023361835- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Radiopharmaceutical Chemistry and Applications
- Mental Health Research Topics
- Functional Brain Connectivity Studies
- Lanthanide and Transition Metal Complexes
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Imaging and Diagnostics
- Neurological disorders and treatments
- Alzheimer's disease research and treatments
- Estrogen and related hormone effects
- Dementia and Cognitive Impairment Research
- Child and Adolescent Psychosocial and Emotional Development
- Stress Responses and Cortisol
- Hypothalamic control of reproductive hormones
- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Parkinson's Disease Mechanisms and Treatments
- Tryptophan and brain disorders
- Neurotransmitter Receptor Influence on Behavior
- Advanced Neuroimaging Techniques and Applications
- Neuropeptides and Animal Physiology
- Treatment of Major Depression
Uppsala University
2015-2024
Uppsala University Hospital
2015-2023
The aim of this study was to explore the cerebral distribution tau-specific PET tracer [18F]THK5317 (also known as (S)-[18F]THK5117) retention in different stages Alzheimer's disease; and any associations with markers hypometabolism amyloid-beta deposition. Thirty-three individuals were enrolled, including nine patients disease dementia, thirteen mild cognitive impairment (MCI), two non-Alzheimer's healthy controls (five young four elderly). In a multi-tracer design [18F]THK5317, [11C]...
Serotonin is involved in negative affect, but whether anxiety syndromes, such as social disorder (SAD), are characterized by an overactive or underactive serotonin system has not been established. 1A autoreceptors, which inhibit synthesis and release, downregulated SAD, transporter availability might be increased; however, presynaptic activity evaluated extensively.To examine the rate patients with SAD healthy control individuals using positron emission tomography (PET) radioligands...
The development of tau-specific positron emission tomography (PET) tracers allows imaging in vivo the regional load tau pathology Alzheimer's disease (AD) and other tauopathies. Eighteen patients with baseline investigations enroled a 17-month follow-up study, including 16 AD (10 had mild cognitive impairment positive amyloid PET scan, that is, prodromal AD, six dementia) two corticobasal syndrome. All underwent scans [18F]THK5317 (tau deposition) [18F]FDG (glucose metabolism) at follow-up,...
Because a correlation between tau pathology and the clinical symptoms of Alzheimer disease (AD) has been hypothesized, there is increasing interest in developing PET tracers that bind specifically to protein. The aim this study was evaluate tracer kinetic models for quantitative analysis generation parametric images novel ligand (<i>S</i>)-<sup>18</sup>F-THK5117. <b>Methods:</b> Nine subjects (5 with AD, 4 mild cognitive impairment) received 90-min dynamic...
<title>Abstract</title> Testosterone and estrogens play significant roles in female physiology, extending beyond reproductive functions to influence brain health, mood regulation, behavior. low-dosage therapy is increasingly considered for alleviating sexual dysfunction symptoms women, has been recently proposed as depressive symptoms, though the mechanisms safety of this approach are not entirely clear. Specifically, effects testosterone use on estrogen synthase (aromatase), which maintains...
In idiopathic Parkinson disease and atypical parkinsonian disorders, central dopaminergic overall brain functional activity are altered to different degrees, causing difficulties in achieving an unambiguous clinical diagnosis. A dual examination using (123)I-FP-CIT ((123)I-N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane, or (123)I-ioflupane) SPECT and(18)F-FDG PET provides complementary information on dopamine transporter (DAT) availability activity, respectively. Parametric...
Abstract It has been extensively debated whether selective serotonin reuptake inhibitors (SSRIs) are more efficacious than placebo in affective disorders, and it is not fully understood how SSRIs exert their beneficial effects. Along with transporter blockade, altered dopamine signaling psychological factors may contribute. In this randomized clinical trial of participants social anxiety disorder (SAD) we investigated manipulation verbally-induced expectancies, vital for response, affect...
The neurokinin-1 (NK1) receptor is abundantly expressed in the fear circuitry of brain, including amygdala, where it modulates stress and anxiety. Despite its proposed involvement psychopathology, only a few studies NK1 availability human subjects with anxiety disorders exist. Here, we compared patients social disorder (SAD; n = 17) healthy controls (n using positron emission tomography radiotracer [11C]GR205171. Patlak Graphical plot cerebellar reference region was used to model influx...
High interstitial fluid pressure (IFP) in colorectal cancer metastases may decrease the uptake and, thus, effects of antitumor drugs. Imatinib, a selective inhibitor platelet-derived growth factor receptors, and anakinra, an interleukin-1 receptor antagonist, respectively, increase drug or IFP preclinical models carcinoma. Drug-induced human has not been objectively shown but should be reflected by water-perfusable tissue fraction (PTF) tumor blood flow (TBF) using (15)O-water PET/CT kinetic...
Cross-sectional findings using the tau tracer [18F]THK5317 (THK5317) have shown that [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET) data can be approximated perfusion measures (early-frame standardized uptake value ratio; ratio of delivery in target to reference regions). In this way, a single PET study provide both functional and molecular information.We included 16 patients with Alzheimer's disease who completed follow-up THK5317 FDG studies 17 months after baseline...
Abstract Animal studies indicate that substance P (SP) and its preferred neurokinin-1 (NK1) receptor modulate stress anxiety-related behavior. Alterations in the SP-NK1 system have also been observed human anxiety disorders, yet little is known about relation between this individual differences personality traits associated with propensity approach-avoidance behavior, including trait anxiety, neuroticism, extraversion. Exploring could provide important insights into neurobiological...
Of interest to women's mental health, a wealth of studies suggests sex differences in nicotine addiction and treatment response, but their psychoneuroendocrine underpinnings remain largely unknown. A pathway involving steroids could indeed be involved the behavioural effects nicotine, as it was found inhibit aromatase vitro vivo rodents non-human primates, respectively. Aromatase regulates synthesis oestrogens and, relevance addiction, is highly expressed limbic brain.The present study...
Abstract Aromatase, the enzyme that in brain converts testosterone and androstenedione to estradiol estrone, respectively, is a putative key factor psychoneuroendocrinology. In vivo assessment of aromatase was performed evaluate tracer kinetic models optimal scan duration, for quantitative analysis positron emission tomography (PET) ligand [ 11 C]cetrozole. Anatomical magnetic resonance 90‐min dynamic C]cetrozole PET‐CT scans were on healthy women. Volume interest (VOI)‐based analyses with...
Abstract Selective serotonin reuptake inhibitors (SSRIs) and internet-based cognitive behavioral therapy (ICBT) are recommended treatments of social anxiety disorder (SAD), often combined, but their effects on monoaminergic signaling not well understood. In this multi-tracer positron emission tomography (PET) study, 24 patients with SAD were randomized to treatment escitalopram+ICBT or placebo+ICBT under double-blind conditions. Before after 9 weeks treatment, examined the radioligands [ 11...
The aim of this retrospective study was to investigate relationships between relative cerebral blood flow and striatal dopamine transporter D2/3 availability in healthy subjects. data comprised dynamic PET scans with two tracers [ 11 C]PE2I (n = 20) 18 F]FE-PE2I the tracer C]raclopride 18). Subjects a scan also underwent serotonin C]DASB. Binding potential (BP ND ) delivery (R 1 values were calculated on regional voxel-level. Striatal R BP correlated, using either an MRI-based volume...