A5010046752- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Prostate Cancer Treatment and Research
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Imaging and Diagnostics
- Advanced X-ray and CT Imaging
- Radiation Dose and Imaging
- Glioma Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- CAR-T cell therapy research
- Social and Educational Sciences
- Neuroendocrine Tumor Research Advances
- Respiratory Support and Mechanisms
- Adolescent Sexual and Reproductive Health
- Computational Drug Discovery Methods
- Sustainable Supply Chain Management
- Brain Tumor Detection and Classification
- Cell Image Analysis Techniques
- Prostate Cancer Diagnosis and Treatment
- Statistical Methods in Clinical Trials
Uppsala University
2018-2025
Uppsala University Hospital
2018-2025
The resolution and quantitative accuracy of PET are highly influenced by the reconstruction method. Penalized-likelihood estimation algorithms allow for fully convergent iterative reconstruction, generating a higher image contrast than ordered-subsets expectation maximization (OSEM) while limiting noise. In this study, type penalized known as block-sequential regularized (BSREM) was compared with time-of-flight OSEM (TOF OSEM). Various strengths noise penalization factor β were tested along...
Abstract Background Prone positioning is part of the management acute respiratory distress syndrome (ARDS) and has been demonstrated to successfully improve ventilation–perfusion match reduce mortality in patients with severe failure. However, effect pronation on other organs than lungs not widely studied. This study aimed compare abdominal edema, perfusion inflammation supine prone a porcine ARDS model. Methods Seventeen piglets were randomized into two groups: group ( n = 9) 8). Both...
Block-sequential regularized expectation maximization (BSREM) is a fully convergent iterative image reconstruction algorithm. We hypothesize that tracers with different distribution patterns will result in optimal settings for the BSREM The aim of this study was to evaluate quality variations applied β-value and acquisition time three positron emission tomography (PET) tracers. NEMA phantom measurements clinical whole-body digital time-of-flight (TOF) PET/computed (CT) examinations...
Accurate localization of recurrent prostate cancer (PCa) is critical, especially if curative therapy intended. With the aim to optimize target-to-background uptake ratio in 68Ga-PSMA-11 PET, we investigated image quality and quantitative measures regularized reconstruction by block-sequential expectation maximization (BSREM). Methods: The study encompassed retrospective analysis 20 digital time-of-flight (TOF) PET/CT examinations acquired 60 min post injection 2 MBq/kg PCa patients with...
Vascular endothelial growth factor receptor-2 (VEGFR2) is a key mediator of angiogenesis and therefore promising therapeutic target in malignancies including glioblastoma multiforme (GBM).Molecular imaging VEGFR2 expression may enable patient stratification for antiangiogenic therapy.The goal the current study was to evaluate capacity novel anti-VEGFR2 biparatopic affibody conjugate (ZVEGFR2-Bp2) vivo visualization GBM.Methods: ZVEGFR2-Bp2 coupled NODAGA chelator generated radiolabeled with...
To assess how some of the new developments in brain positron emission tomography (PET) image reconstruction affect quantitative measures and software-aided assessment pathology patients with neurodegenerative diseases. PET data were grouped into four cohorts: prodromal Alzheimer's disease controls receiving [18F]flutemetamol, [18F]FDG scans. Reconstructed images obtained by ordered-subsets expectation maximization (OSEM; 3 iterations (i), 16/34 subsets (s), 3/5-mm filter, ±time-of-flight...
Coronavirus disease 2019 (COVID-19) can cause life-threatening lung inflammation that is thought to be mediated by neutrophils. The aim of the present work was evaluate a novel PET tracer for neutrophil elastase (NE). <b>Methods:</b> In this first-in-humans study, 4 patients with hypoxia due COVID-19 and 2 healthy controls were investigated using <sup>11</sup>C-NES <sup>15</sup>O-water visualization quantification NE perfusion in lungs, respectively. <b>Results:</b><sup>11</sup>C-NES...
Abstract Aim The aim of this prospective study was to evaluate a data-driven gating software’s performance, in terms identifying the respiratory signal, comparing [ 68 Ga]Ga-DOTATOC and 18 F]FDG examinations. In addition, for examinations, tracer uptake quantitation liver lesion detectability were assessed. Methods Twenty-four patients with confirmed or suspected neuroendocrine tumours underwent whole-body PET/CT Prospective DDG applied on all bed positions motion correction triggered...
Abstract Positron emission tomography (PET) imaging is used to localize recurrent disease in prostate cancer (PCa). The tracer 68 Ga-PSMA-11 visualizes lesions overexpressing prostate-specific membrane antigen (PSMA), while 11 C-acetate with increased anabolic metabolism. aim of this study was compare the performance PSMA-PET and acetate-PET re-staging patients biochemical relapse. Thirty PCa (PSA) relapse after primary curative therapy were prospectively evaluated. PET/CT examinations using...
18F-NaF positron emission tomography/computed tomography (fluoride PET/CT) is considered the most sensitive technique to detect bone metastasis in prostate cancer (PCa). 68Ga-PSMA-11 (PSMA) PET/CT increasingly used for staging of PCa. This study primarily aimed compare diagnostic performance fluoride and gallium-based PSMA identifying followed by a comparison with contrast-enhanced CT (CE-CT) soft tissue lesions as secondary objective.Twenty-eight PCa patients high suspicion disseminated...
Abstract Background Respiratory motion during PET imaging reduces image quality. Data-driven gating (DDG) based on principal component analysis (PCA) can be used to identify respiratory signals. The use of DDG, without need for external devices, would greatly increase the feasibility using in a routine clinical setting. objective this study was evaluate data-driven relation hardware and regular static acquisition PET-MRI data with respect SUV max lesion volumes. Methods Sixteen patients...
The impact on quantitative
Abstract Introduction Patient motion is a common problem in cardiac PET, impairing the diagnostic accuracy of hemodynamically significant CAD for both qualitative and quantitative assessments. Motion correction PET challenging general because time-varying distribution tracer, even more so 15O-water due to its lack retention myocardium. The aim present work was evaluate frame-by-frame method using patient specific synthetic dynamic reference. Materials Methods implemented as follows....