A5010279400- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Pain Mechanisms and Treatments
- Musculoskeletal pain and rehabilitation
- Pain Management and Placebo Effect
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Functional Brain Connectivity Studies
- Spinal Cord Injury Research
- Mental Health Research Topics
- Pain Management and Treatment
- Migraine and Headache Studies
- Stroke Rehabilitation and Recovery
- Traumatic Brain Injury Research
- Neuroscience and Neuropharmacology Research
- Child and Adolescent Psychosocial and Emotional Development
- Obsessive-Compulsive Spectrum Disorders
- Advanced Neuroimaging Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Laser Applications in Dentistry and Medicine
- Neural and Behavioral Psychology Studies
- Neuropeptides and Animal Physiology
- Anesthesia and Pain Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Spinal Dysraphism and Malformations
Harvard University
2016-2025
Spaulding Rehabilitation Hospital
2018-2025
Massachusetts General Hospital
2010-2023
University of Minnesota
2023
Boston University
2021
Boston Children's Hospital
2012-2020
Montreal Neurological Institute and Hospital
2020
McGill University
2020
Athinoula A. Martinos Center for Biomedical Imaging
2020
Boston Children's Museum
2015-2017
Medial prefrontal cortical areas have been hypothesized to underlie altered contextual processing in posttraumatic stress disorder (PTSD). We investigated brain signaling of information this disorder. Eighteen PTSD subjects and 16 healthy trauma-exposed underwent a two-day fear conditioning extinction paradigm. On day 1, within visual context A, conditioned stimulus (CS) was followed 60% the time by an electric shock (conditioning). The response then extinguished (extinction learning) B. 2,...
Neurobiological models of obsessive-compulsive disorder (OCD) predict hyperactivity in brain circuits involving the orbitofrontal cortex and basal ganglia, but it is unclear whether these areas are also characterized by altered network properties.To determine regions abnormal degree connectivity patients with OCD to investigate measures affected antidepressant medication OCD.Case-control cross-sectional study using resting-state functional magnetic resonance imaging a data-driven, model-free...
The amygdala, a small deep brain structure involved in behavioral processing through interactions with other regions, has garnered increased attention recent years relation to pain processing. As is multidimensional experience that encompasses physical sensation, affect, and cognition, the amygdala well suited play part this process. Multiple neuroimaging studies of humans have reported activation amygdala. Here, we summarize these by performing coordinate‐based meta‐analysis within...
Migraine is twice as common in females males, but the mechanisms behind this difference are still poorly understood. We used high-field magnetic resonance imaging male and female age-matched interictal (migraine free) migraineurs matched healthy controls to determine alterations brain structure. Female had thicker posterior insula precuneus cortices compared with of both sexes. Furthermore, evaluation functional responses heat within migraine groups indicated concurrent differences a...
Placebo may yield beneficial effects that are indistinguishable from those of active medication, but the factors underlying proneness to respond placebo widely unknown. Here, we used functional neuroimaging examine neural correlates anxiety reduction resulting sustained treatment under randomized double-blind conditions, in patients with social disorder. Brain activity was assessed during a stressful public speaking task by means positron emission tomography before and after an 8 week...
The amygdala, hippocampus, medial prefrontal cortex (mPFC) and brain-stem subregions are implicated in fear conditioning extinction, brain regions known to be sexually dimorphic. We used functional magnetic resonance imaging (fMRI) investigate sex differences activity these during extinction.Subjects were 12 healthy men comparable women who underwent a 2-day experiment 3 T MR scanner. Fear extinction learning occurred on day 1 recall 2. conditioned stimuli visual cues the unconditioned...
Summary Amygdala connectivity is altered in children with chronic neuropathic pain and responsive to intensive interdisciplinary treatment, an associated decrease pain-related fear. The amygdala a key brain region efferent afferent neural connections that involve complex behaviors such as pain, reward, fear, anxiety. This study evaluated resting state functional of the cortical subcortical regions group patients (pediatric regional syndrome) age-sex matched control subjects before after...
Serotonin is involved in negative affect, but whether anxiety syndromes, such as social disorder (SAD), are characterized by an overactive or underactive serotonin system has not been established. 1A autoreceptors, which inhibit synthesis and release, downregulated SAD, transporter availability might be increased; however, presynaptic activity evaluated extensively.To examine the rate patients with SAD healthy control individuals using positron emission tomography (PET) radioligands...
Humans commit more violent crimes when temperature and air pollution is higher. Here, we investigate if also the day-to-day rates of dogs biting humans influenced by environmental factors. 69,525 reports humans, sourced from public records on animal control requests ER records, were analyzed. The impact pollutants evaluated with a zero-inflated Poisson generalized additive model, while controlling for regional calendar effects. Exposure-response curves used to assess association between...
This study investigated sex similarities and differences in pain-related functional connectivity 60 healthy subjects. We used magnetic resonance imaging psychophysiological interaction analysis to investigate how exposure low vs high experimental pain modulates the of periaqueductal gray (PAG). found no thresholds, both men women, PAG was more functionally connected with somatosensory cortex, supplemental motor area, cerebellum, thalamus during pain, consistent anatomic predictions....
Objective: Individual differences in a person's ability to control fear have been linked activation the dorsal anterior cingulate cortex, ventromedial prefrontal and amygdala. This study investigated whether functional variance this network can be predicted by resting metabolism these same regions. Method: The authors measured brain healthy volunteers with positron emission tomography using [18F]fluorodeoxyglucose. was followed 2-day conditioning extinction training paradigm MRI measure...
Both fear and pain processing are altered in post-traumatic stress disorder (PTSD), as evidenced by functional neuroimaging studies showing increased amygdala responses to threats, insula, putamen caudate activity response heat pain. Using psychophysiology magnetic resonance imaging, we studied conditioned unconditioned autonomic neuronal subjects with PTSD versus trauma-exposed non-PTSD control (TENC) subjects. A design using an electric shock selected be 'highly annoying but not painful'...
Exposure-based therapy, an effective treatment for posttraumatic stress disorder (PTSD), relies on extinction learning principles. In PTSD patients, dysfunctional patterns in the neural circuitry underlying fear have been observed using resting-state or functional activation measures. It remains undetermined whether resting activity predicts activations during recall symptom severity. Moreover, it unclear trauma exposure per se affects this circuitry. The authors employed a multimodal...