A5103415629- Pain Mechanisms and Treatments
- Pain Management and Placebo Effect
- Musculoskeletal pain and rehabilitation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Empathy and Medical Education
- Pediatric Pain Management Techniques
- Myofascial pain diagnosis and treatment
- Gastrointestinal motility and disorders
- Acupuncture Treatment Research Studies
- Complementary and Alternative Medicine Studies
- Anesthesia and Pain Management
- Neuroscience and Neuropharmacology Research
- Botulinum Toxin and Related Neurological Disorders
- Neuropeptides and Animal Physiology
- Pain Management and Treatment
- Heart Rate Variability and Autonomic Control
- Neuroscience, Education and Cognitive Function
- Ion channel regulation and function
- Infrared Thermography in Medicine
- Neurology and Historical Studies
- Pain Management and Opioid Use
- Psychosomatic Disorders and Their Treatments
- Anesthesia and Sedative Agents
- Peripheral Nerve Disorders
- Thermoregulation and physiological responses
National Renewable Energy Laboratory
2024
Vidant Medical Center
2021
East Carolina University
2021
University of Florida
2008-2017
Florida College
2004-2015
National Medical Research Center of Dentistry and Maxillofacial Surgery
2007-2015
Virginia Commonwealth University
1978-2014
Allen Institute for Brain Science
2002-2013
De Montfort University
2005-2011
Commonwealth Scientific and Industrial Research Organisation
2011
Clinical criteria for the diagnosis of Alzheimer9s disease include insidious onset and progressive impairment memory other cognitive functions. There are no motor, sensory, or coordination deficits early in disease. The cannot be determined by laboratory tests. These tests important primarily identifying possible causes dementia that must excluded before may made with confidence. Neuropsychological provide confirmatory evidence help to assess course response therapy. proposed intended serve...
Visual analogue scales (VAS) of sensory intensity and affective magnitude were validated as ratio scale measures for both chronic experimental pain. Chronic pain patients healthy volunteers made VAS responses to 6 noxious thermal stimuli (43, 45, 47, 48, 49 51°C) applied 5 sec the forearm by a contact thermode. Sensory these temperatures yielded power functions with exponents 2.1 3.8, respectively; similar volunteers. The predictive estimated ratios sensation or affect produced pairs...
Recent evidence demonstrating multiple regions of human cerebral cortex activated by pain has prompted speculation about their individual contributions to this complex experience. To differentiate cortical areas involved in affect, hypnotic suggestions were used alter selectively the unpleasantness noxious stimuli, without changing perceived intensity. Positron emission tomography revealed significant changes pain-evoked activity within anterior cingulate cortex, consistent with encoding...
Clinical criteria for the diagnosis of Alzheimer's disease include insidious onset and progressive impairment memory other cognitive functions.There are no motor, sensory, or coordination deficits early in disease.The cannot be determined by laboratory tests.These tests important primarily identifying possible causes dementia that must excluded before may made with confidence.Neuropsychological provide confirmatory evidence help to assess course response therapy.The proposed intended serve...
Numerical rating scales and mechanical visual analogue (M-VAS) were compared for their capacity to provide ratio scale measures of experimental pain. Separate estimates pain sensation intensity unpleasantness obtained by each method, as clinical Orofacial patients made numerical VAS ratings in response noxious thermal stimuli (45–51°C) applied 5 sec the forearm a contact thermode. The derived stimulus-response function was well fit power only case sensory M-VAS. from M-VAS predicted...
Although individuals with fibromyalgia syndrome (FMS) consistently report wide-spread pain, clear evidence of structural abnormalities or other sources chronic stimulation pain afferents in the involved body areas is lacking. Without convincing for peripheral tissue FMS patients, it seems likely that a central pathophysiological process at least partly responsible FMS, as case many conditions. Therefore, present study sought to obtain psychophysical possibility input nociceptive pathways...
Psychophysical experiments were carried out on 6 human subjects to determine how first and second pain are influenced by peripheral receptor mechanisms central nervous system inhibitory facilitatory mechanisms. For these experiments, brief natural painful stimuli delivered the hand a train of 4–8 constant waveform heat pulses generated contact thermode (peak temp. = 51.5°C). The magnitude sensations was estimated using cross-modality matching procedures reaction times determined. latter...
Placebo analgesia was produced by conditioning trials wherein heat induced experimental pain surreptitiously reduced in order to test psychological factors of expectancy and desire for reduction as possible mediators placebo analgesia. The magnitudes effects were assessed after these during stimulus intensities reestablished original baseline levels. In addition, analyses made the influence on concurrently remembered intensities. Statistically reliable sensory affective measures graded...
Whether elevated beta-secretase (BACE) activity is related to plaque formation or amyloid beta peptide (Abeta) production in Alzheimer's disease (AD) brains remains inconclusive. Here, we report that used sandwich enzyme-linked immunoabsorbent assay quantitate various Abeta species the frontal cortex of AD homogenized 70% formic acid. We found most detected rapidly autopsied (<3 h) with sporadic were Abeta(1-x) and Abeta(1-42), as well Abeta(x-42). To establish a linkage between levels BACE,...
In a rat model of morphine tolerance, we examined the hypotheses that thermal hyperalgesia to radiant heat develops in association with development tolerance and both expression morphine-tolerant rats are mediated by central NMDA non-NMDA receptors subsequent protein kinase C (PKC) activation. Tolerance analgesic effect was developed utilizing an intrathecal repeated treatment regimen. The employing tail-flick test paw-withdrawal test, respectively. Intrathecal MK 801 (an receptor...
Abstract The neural mechanisms underlying hypnotic states and responses to suggestions remain largely unknown and, date, have been studied only with indirect methods. Here, the effects of hypnosis alter pain perception were investigated in hypnotizable subjects by using positron emission tomography (PET) measures regional cerebral blood flow (rCBF) electroencephalographic (EEG) brain electrical activity. experimental conditions included a restful state (Baseline) followed relaxation alone...
Abstract Judgments of the intensity a stimulus are dependent on level central nervous system activity it generates. Generally, is assumed that such judgments based along modality-specific pathways. Thus, visual would be unimodal activity. However, many neurons do not fit neatly within categories, but can influenced by more than one sensory modality. Often "multisensory" effect quite pronounced. If these multisensory participate in fundamental functions as perceived intensity, presence...
Different types of pain patients used visual analogue scales (VAS) to rate their level sensation intensity (VAS sensory) and degree unpleasantness affective) associated with experienced at its maximum, usual, minimum intensity. Women the same VAS labor during early, active, transition phases stage I in pushing (stage II). Consistent hypothesis that affective dimension clinical can be selectively augmented by perceived threat health or life, cancer chronic gave higher ratings as compared...
Individuals diagnosed with fibromyalgia syndrome (FMS) report chronic pain that is frequently worsened by physical activity and improved rest. Palpation of muscle tendinous structures suggests nociceptors in deep tissues are abnormally sensitive FMS, but methods controlled mechanical stimulation muscles needed to better characterize the sensitivity tissues. Accordingly, force-controlled was applied flexor digitorum forearm a series brief contacts (15 stimuli, each 1s duration, at 3 or 5s...