A5083021518- Pain Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Diabetes Management and Research
- Heart Rate Variability and Autonomic Control
- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Chronic Disease Management Strategies
- Skin and Cellular Biology Research
- Blood Pressure and Hypertension Studies
- Diabetes Management and Education
- Schizophrenia research and treatment
- Diabetes and associated disorders
- Primary Care and Health Outcomes
- Neurological Disorders and Treatments
- Diet and metabolism studies
- Cardiovascular Function and Risk Factors
- Chronic Kidney Disease and Diabetes
- Health Promotion and Cardiovascular Prevention
- Family Support in Illness
- Sexual function and dysfunction studies
- Cardiac Health and Mental Health
- Traditional Chinese Medicine Studies
- Peripheral Nerve Disorders
- Mobile Health and mHealth Applications
Steno Diabetes Centers
2019-2025
Aarhus University
2015-2024
Aarhus University Hospital
2014-2024
Ann Arbor Center for Independent Living
2023
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2021
Gentofte Hospital
2020
Danish College of General Practitioners
2018
Public Health Institute
2011-2017
University of Washington
2015
Danish National Institute of Public Health
2012
OBJECTIVE To study incident diabetic polyneuropathy (DPN) prospectively during the first 13 years after a screening-based diagnosis of type 2 diabetes and determine associated risk factors for development DPN. RESEARCH DESIGN AND METHODS We assessed DPN longitudinally in Danish arm Anglo-Danish-Dutch Intensive Treatment Diabetes Primary Care (ADDITION) using Michigan Neuropathy Screening Instrument questionnaire (MNSIQ), defining with scores ≥4. Risk present at were estimated Cox...
IMPORTANCEAlthough schizophrenia is associated with several age-related disorders and considerable cognitive impairment, it remains unclear whether the risk of dementia higher among persons compared those without schizophrenia.OBJECTIVE To determine in a large nationwide cohort study up to 18 years follow-up, taking age established factors for into account. DESIGN, SETTING, AND PARTICIPANTSThis population-based more than 2.8 million aged 50 or older used individual data from 6 registers...
OBJECTIVE To examine the course of cardiovascular autonomic neuropathy (CAN) and related cardiometabolic risk factors in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS CAN were assessed Danish arm Anglo-Danish-Dutch Study Intensive Treatment People With Screen-Detected Diabetes Primary Care (ADDITION-Denmark) at 6-year (n = 777) 13-year 443) follow-up examinations. Cardiovascular reflex tests (CARTs)—that is, lying to standing, deep breathing, Valsalva maneuver—and 2-min resting...
OBJECTIVE To investigate the longitudinal development of neurofilament light chain (NfL) levels in type 2 diabetes with and without diabetic polyneuropathy (+/−DPN) to explore predictive potential NfL as a biomarker for DPN. RESEARCH DESIGN AND METHODS We performed retrospective case-control analysis data from 178 participants Anglo-Danish-Dutch Study Intensive Treatment People Screen-Detected Diabetes Primary Care-Denmark (ADDITION-Denmark) cohort people screen-detected diabetes. Biobank...
There is limited evidence on how intensive multifactorial treatment (IT) improves outcomes of diabetes when initiated in the lead time between detection by screening and diagnosis routine clinical practice. We examined effects early IT type 2 primary care prevalence diabetic peripheral neuropathy (DPN) arterial disease (PAD) 6 years later a pragmatic, cluster-randomized parallel group trial.A stepwise program 190 general practices Denmark was used to identify 1,533 people with diabetes....
The global rise in type 2 diabetes is associated with a concomitant increase diabetic complications. Diabetic polyneuropathy the most frequent complication and poor outcomes. metabolic syndrome has emerged as major risk factor for polyneuropathy; however, metabolites that correlate are unknown.
Persons with severe mental illness (SMI) have excess mortality, which may partly be explained by their high prevalence of diabetes.We compared the overall and cause-specific mortality in persons SMI diabetes that general Danish population between 1997 2009 linking data from national registries.The cohort counted 4 734 703 persons, during follow-up 651 080 died whom 1083 had diabetes. Compared background population, rate ratios (MRRs) for were 4.14 [95% confidence interval (CI) 3.81-4.51] men...
Diabetic neuropathy (DN) affects up to half of individuals with type 1 and 2 diabetes. Despite evidence that improving metabolic cardiovascular health can slow its progression, DN remains a significant clinical challenge due the lack disease-modifying therapies effective pain management strategies. This consensus aimed identify gaps recommend strategies address these challenges. A workshop, initiated by Steno Diabetes Centre Copenhagen Danish Endocrinology Academy, conducted gap analysis...
To describe the clinical characteristics, comorbidity, and medical treatment in a primary care population with chronic kidney disease (CKD). Additionally, to investigate how physicians (PCPs) diagnose, manage treat impaired function, including uptake of cardio-renoprotective renin-angiotensin-aldosterone system inhibitors (RAASis) sodium glucose co-transporter 2 (SGLT2is). An observational study CKD prevalence, patterns comorbidities based on patient record data combined questionnaire...
OBJECTIVE Slow nerve conduction velocity and reduction in response amplitude are objective hallmarks of diabetic sensorimotor polyneuropathy. Because subjective or clinical indicators neuropathy do not always match well with the presence abnormal physiology tests, we evaluated associations to patients type 1 diabetes. RESEARCH DESIGN AND METHODS Nerve studies were performed distal sural ulnar sensory nerves peroneal motor 456 individuals diabetes who participated follow-up visit EURODIAB...
Objective: Persons with severe mental illness die 15–20 years earlier on average than persons without illness. Although infection is one of the leading overall causes death, no studies have evaluated whether a higher mortality after those without. Method: The authors studied rate ratios and cumulative proportions an admission for compared by linking data from Danish national registries. Results: cohort consisted all hospitalized during period 1995–2011 in Denmark (N=806,835), whom 11,343 had...
Cardiovascular autonomic neuropathy and diabetic peripheral are common complications independent predictors of cardiovascular disease. The glucose metabolite methylglyoxal has been suggested to play a causal role in the pathogeneses possibly neuropathy. aim this study was investigate cross-sectional association between serum subset patients ADDITION-Denmark with short-term screen-detected Type 2 diabetes (duration ~ 5.8 years).The were well controlled regard HbA(1c), lipids blood pressure....
OBJECTIVE To study cardiometabolic risk-factor trajectories (in terms of levels and changes over time) preceding diabetic polyneuropathy (DPN) 13 years after a screen-detected diagnosis type 2 diabetes. RESEARCH DESIGN AND METHODS We clinically diagnosed DPN in nested case-control 452 people the Danish arm Anglo-Danish-Dutch Study Intensive Treatment People with Screen-Detected Diabetes Primary Care (ADDITION). By linear regression models, we estimated during years. Risk was by multivariate...
To determine bidirectional associations between the timing of chronic diabetes complications (CDCs) and mental health disorders (MHDs) in individuals with type 1 or 2 diabetes.
AimsTo investigate the relationship between neurofilament light chain (NfL) and presence severity of diabetic polyneuropathy (DPN).MethodsWe performed cross-sectional analysis data from 178 participants ADDITION-Denmark cohort people with screen-detected type 2 diabetes 32 healthy controls. Biobank serum samples were analyzed for NfL using single-molecule array. DPN was defined by Toronto criteria confirmed DPN. Original axonal nerve conduction study (NCS) sum z-scores used as indicators...
Breast cancer is the leading cause of death in women worldwide. Nevertheless, it unknown whether higher mortality after breast contributes to life-expectancy gap 15 years with severe mental illness (SMI).We estimated all-cause rate ratios (MRRs) SMI, and both disorders compared neither disorder using data from nationwide registers Denmark for 1980-2012.The cohort included 2.7 million women, hereof 31,421 SMI (12,852 deaths), 104,342 (52,732 1,106 (656 deaths). Compared disorder, was 118%...
OBJECTIVE Type 1 diabetes is a complex disease, and development of multiple complications over time can be analyzed only with advanced statistical methods. This study describes the microvascular explores effect complication burden important concurrent risk factors by applying multistate model. RESEARCH DESIGN AND METHODS We used clinical cohort at Steno Diabetes Center Copenhagen to diabetic kidney retinopathy, neuropathy. extracted information from electronic patient records estimated...
Diabetic retinopathy (DR) screening methods are costly, requiring specialized personnel and patient mydriasis. The Optos apparatus can be operated by nonspecialists provides ultra-wide-field imaging, with 200° views of the retina in a single image. We compared DR grading obtained from imaging conventional Topcon imaging.We conducted cross-sectional study 101 persons diabetes who participated Addition-DK 10-year follow-up study. Retina fundus photos using both were taken for eyes. All graded...