A5032859773- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Mitochondrial Function and Pathology
- Botulinum Toxin and Related Neurological Disorders
- Genetic Neurodegenerative Diseases
- Organ Donation and Transplantation
- Restless Legs Syndrome Research
- Neurogenetic and Muscular Disorders Research
- Amyotrophic Lateral Sclerosis Research
- Clinical Nutrition and Gastroenterology
- Neurological diseases and metabolism
- Neurological and metabolic disorders
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Liver Disease and Transplantation
- Drug Transport and Resistance Mechanisms
- Pancreatic and Hepatic Oncology Research
- Estrogen and related hormone effects
- Autoimmune Neurological Disorders and Treatments
- Functional Brain Connectivity Studies
- Genetics and Neurodevelopmental Disorders
- Sleep and Wakefulness Research
- Renal and Vascular Pathologies
Istituto delle Scienze Neurologiche di Bologna
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2025
Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione
2025
University of Palermo
2022-2025
Cytodiagnostics (Canada)
2024
University of Bologna
2012-2021
Case Western Reserve University
2021
University School
2021
Ospedale Bellaria
2017-2021
Istituto Zooprofilattico Sperimentale delle Venezie
2019-2020
Caveolins-1 and -2 are normally co-expressed, they form a hetero-oligomeric complex in many cell types. These caveolin hetero-oligomers thought to represent the assembly units that drive caveolae formation <i>in vivo</i>. However, functional significance of interaction between caveolins-1 remains unknown. Here, we show caveolin-1 co-expression is required for transport caveolin-2 from Golgi plasma membrane. We identified human erythroleukemic line, K562, expresses but fails express...
Objective Mounting evidence links neurodegenerative disorders such as Parkinson disease and Alzheimer with mitochondrial dysfunction, recent emphasis has focused on dynamics quality control. Mitochondrial mtDNA maintenance is another link recently emerged, implicating mutations in the fusion genes OPA1 MFN2 pathogenesis of multisystem syndromes characterized by neurodegeneration accumulation multiple deletions postmitotic tissues. Here, we report 2 Italian families affected dominant chronic...
Optic neuropathy is common in mitochondrial disorders, but poorly characterized Friedreich's ataxia (FRDA), a recessive condition caused by lack of the protein frataxin. We investigated 26 molecularly confirmed FRDA patients studying both anterior and posterior sections visual pathway using new, integrated approach. This included field testing optical coherence tomography (OCT), pattern evoked potentials (P-VEPs) diffusion-weighted imaging. The latter was used to study optic radiation...
Corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) are two neurodegenerative disorders within the category of tauopathies, which must be considered in differential diagnosis Parkinson's disease. Although specific clinical neuroradiological features help to guide clinician a likely disease, CBD or PSP, remains difficult. The aim our study was analyse apparent diffusion coefficient (ADCave) maps from patients with (corticobasal syndrome, CBS), classical phenotype PSP...
ABSTRACT Background The objective of this study was to use phase imaging evaluate brain iron content in patients with idiopathic restless legs syndrome (RLS). Methods Fifteen RLS and 15 healthy controls were studied using gradient‐echo imaging. Phase analysis performed on localized regions interest selected maps, sensitive paramagnetic tissue. Differences between the 2 subject groups evaluated ANCOVA including age as a covariate. Results Significantly higher values present compared at level...
To investigate whether (1) phosphorylated α-synuclein (p-syn) deposits in skin nerves could be useful differentiating dementia with Lewy bodies (DLB) from different forms of and (2) small fiber neuropathy (SFN) is associated DLB.We studied 18 well-characterized patients DLB (11 autonomic dysfunction), 23 nonsynucleinopathy (NSD; 13 young-onset Alzheimer disease dementia, 6 frontotemporal 4 vascular dementia), 25 healthy controls. All participants underwent biopsies proximal (i.e., cervical)...
To determine whether (1) immunofluorescence is a reproducible technique in detecting misfolded α-synuclein skin nerves and subsequently (2) real-time quaking-induced conversion (RT-QuIC) (both CSF) show comparable vivo diagnostic accuracy distinguishing synucleinopathies from non-synucleinopathies large cohort of patients.
We aimed to characterize in vivo α-synuclein (α-syn) aggregates skin nerves ascertain: 1) the optimal marker identify them; 2) possible differences between synucleinopathies that may justify clinical variability. studied multiple nerve α-syn deposits 44 patients with synucleinopathy: 15 idiopathic Parkinson's disease (IPD), 12 dementia Lewy Bodies (DLB), 5 pure autonomic failure (PAF) and system atrophy (MSA). Ten healthy subjects were used as controls. Antibodies against native α-syn,...
Neurological manifestations can occur during coronavirus disease 19 (COVID-19). Several pathogenic mechanisms have been hypothesized, without conclusive results. In this study, we evaluated the most frequent neurological symptoms in a cohort of hospitalized COVID-19 patients, and also investigated possible relationship between plasmatic inflammatory indices olfactory disorders (ODs) muscle pain creatine kinase (CK).We consecutively enrolled patients. A structured questionnaire concerning...
Abstract To compare the diagnostic accuracy of immunofluorescence (IF) technique and aSyn-seed amplification assay (aSyn-SAA) skin cerebrospinal fluid (CSF) in disclosing pathological α-syn idiopathic REM sleep behavior disorder (iRBD) as early phase a synucleinopathy. We prospectively recruited 41 patients with iRBD 40 matched clinical controls including RBD associated type 1 Narcolepsy (RBD-NT1, 21 patients), iatrogenic causes (2 pt) or OSAS (6 11 peripheral neuropathies. IF from samples...
Lipoxins and aspirin-triggered 15- epi -lipoxins (ATL) are counter-regulatory eicosanoids with potent antiinflammatory actions. Oral efficacy mechanism of action ZK-192, a β-oxidation-resistant 3-oxa-ATL analog, were examined in trinitrobenzenesulphonate (TNBS)-induced colitis. When dosed orally once daily, 300 1,000 μg/kg ZK-192 markedly attenuated TNBS colitis rodents both preventive therapeutic regimens. weight loss, macroscopic histologic colon injury, mucosal neutrophil infiltration,...
The differentiation of a preadipocyte into mature adipocyte is highly regulated process that requires scripted program transcriptional events leading to changes in gene expression. Several genes are associated with adipogenesis, including the CAAT/enhancer-binding protein (C/EBPs) and peroxisome proliferator-activated receptor (PPAR) families transcription factors. In this study, we have investigated role farnesoid X (FXR), bile acid-activated nuclear receptor, regulating adipogenesis cell...
Background and purpose: Optic nerve involvement is frequent in mitochondrial disease, retinal abnormalities are described Parkinson’s disease (PD). Methods: We evaluated fiber layer (RNFL) thickness by optical coherence tomography 43 patients with PD 86 age‐matched controls. considered separately the eyes ipsilateral contralateral to most affected body side PD. ancova analysis, Pearson test, multiple regression analysis were used ( P < 0.05). Results: Patients showed significantly thinner...
Abstract Aging is a major risk factor for progression of liver diseases to hepatocellular carcinoma (HCC). Cellular senescence contributes age-related tissue dysfunction, but the epigenetic basis underlying drug-induced remains unclear. macroH2A1, variant histone H2A, marker senescence-associated heterochromatic foci that synergizes with DNA methylation silence tumor-suppressor genes in human fibroblasts. In this study, we investigated relationship between macroH2A1 splice variants,...