A5024746609- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Metabolomics and Mass Spectrometry Studies
- Diet, Metabolism, and Disease
- Sirtuins and Resveratrol in Medicine
- Gut microbiota and health
- Muscle metabolism and nutrition
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Regulation of Appetite and Obesity
- Nutritional Studies and Diet
- Peroxisome Proliferator-Activated Receptors
- Nutrition, Genetics, and Disease
- Dietary Effects on Health
- Cardiovascular Disease and Adiposity
- PARP inhibition in cancer therapy
- Genital Health and Disease
- Drug Transport and Resistance Mechanisms
- Cholesterol and Lipid Metabolism
- Fatty Acid Research and Health
- Phytoestrogen effects and research
- Cancer, Hypoxia, and Metabolism
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2016-2025
École Polytechnique Fédérale de Lausanne
2009-2013
Nestlé (Switzerland)
2011
Inserm
2009
Centre National de la Recherche Scientifique
2009
Institut de génétique et de biologie moléculaire et cellulaire
2009
Center for Research and Advanced Studies of the National Polytechnic Institute
2007
To study the effects of a functional food-based dietary intervention on faecal microbiota and biochemical parameters in patients with type 2 diabetes (T2D). This placebo-controlled, randomized, double-blind included 81 T2D divided into two 3-month treatment groups: one following reduced-energy diet portfolio (DP) comprising high-fibre, polyphenol-rich vegetable-protein foods; other taking placebo (P). The primary outcome was effect DP microbiota. Secondary endpoints were parameters,...
Sirt5, localized in the mitochondria, is a member of sirtuin family NAD⁺-dependent deacetylases. Sirt5 was shown to deacetylate and activate carbamoyl phosphate synthase 1. Most recently, reported be predominant protein desuccinylase demalonylase mitochondria because ablation enhanced global succinylation malonylation mitochondrial proteins, including many metabolic enzymes. In order determine physiological role homeostasis, we generated germline deficient (Sirt5⁻/⁻) mouse model performed...
Obesity and its comorbidities are a severe public health problem worldwide. The use of bioactive compounds found in some foods has been demonstrated to ameliorate the metabolic abnormalities associated with obesity. purpose this study was assess whether present aguamiel concentrate (AC) from Agave salmiana could attenuate glucose intolerance hepatic steatosis mice fed high fat (HF) diet. HPLC-ELSD analysis showed that AC contained several saponins. consumption an extract rich saponins...
Objective Obesity is associated with metabolic abnormalities, including insulin resistance and dyslipidemias. Previous studies demonstrated that genistein intake modifies the gut microbiota in mice by selectively increasing Akkermansia muciniphila , leading to reduction of endotoxemia sensitivity. However, it not known whether consumption humans obesity could modify reducing Research design methods 45 participants a Homeostatic Model Assessment (HOMA) index greater than 2.5 body mass indices...
BackgroundMitochondrial dysfunction occurs in monocytes during obesity and contributes to a low-grade inflammatory state; therefore, maintaining good mitochondrial conditions is key aspect of health. Dietary interventions are primary strategies for treating obesity, but little known about their impact on monocyte bioenergetics. Thus, the aim this study was evaluate effects calorie restriction (CR), intermittent fasting (IF), ketogenic diet (KD), an ad libitum habitual (AL) function its...
Obesity is frequently associated with the consumption of high carbohydrate/fat diets leading to hyperinsulinemia. We have demonstrated that soy protein (SP) reduces hyperinsulinemia, but it unclear by which mechanism. Thus, purpose present work was establish whether SP stimulates insulin secretion a lower extent and/or resistance, and understand its molecular mechanism action in pancreatic islets rats diet-induced obesity. Long-term fat (HF) diet significantly decreased serum glucose, free...
A diet rich in polyphenols can ameliorate some metabolic alterations associated with obesity and type 2 diabetes. Opuntia ficus-indica (OFI) is a plant isorhamnetin glycosides highly consumed Mexico. The purpose of this research was to determine the effect an OFI extract on mouse model diet-induced isolated pancreatic islets. added high fat (HF) at low (0.3%) or (0.6%) dose administered C57BL/6 mice for 12 weeks. Mice fed HF supplemented gained less body weight exhibited significantly lower...
The aim of this study is to assess whether the long-term addition genistein a high-fat diet can ameliorate metabolic and cognitive alterations changes be associated with modifications gut microbiota.C57/BL6 mice were fed either control (C) diet, (HF) or containing (HFG) for 6 months. During study, indirect calorimetry, IP glucose tolerance tests, behavioral analyses performed. At end plasma, liver, brain, fecal samples collected. results showed that HFG gained less weight, had lower serum...
Adipocytes are the main cell type in adipose tissue, which is a critical regulator of metabolism, highly specialized storing energy as fat. differentiate from multipotent mesenchymal stromal cells (hMSCs) through adipogenesis, tightly controlled differentiation process involving close interplay between metabolic transitions and sequential programs gene expression. However, specific gears driving this remain largely obscure. Additionally, metabolite nicotinamide adenine dinucleotide (NAD+)...
Abstract Subcutaneous (SAT) and visceral (VAT) adipose tissues stores excess energy as triglycerides synthesize adiponectin to prevent ectopic lipid accumulation lipotoxicity. During obesity, an impairment in the capacity of SAT store is associated with increased free fatty acids (FFA) release, leading VAT hypertrophy hepatic skeletal muscle Endoplasmic reticulum (ER) stress unfolded protein response (UPR) may be involved dysfunction during obesity. The objectives this study were assess UPR...
Scope There is few information about the possible health effects of a food combination based on pre‐hispanic Mexican diet (PMD). This rich in fiber, polyphenols, healthy ratio omega 6/omega 3 fatty acids, and vegetable protein could improve carbohydrate lipid metabolism, gut microbiota cognitive function. Methods results We examined effect PMD sucrose enriched high‐fat model. The contains corn, beans, tomato, nopal, chia pumpkin seeds dehydrated form. Following induction obesity, rats were...
Omega-3 fatty acids (w-3 FA) have anti-inflammatory effects and improve mitochondrial function. Nonetheless, little is known about their effect on bioenergetics of peripheral blood mononuclear cells (PBMCs) in individuals with obesity. Thus, this study aimed to determine the status cell subset composition PBMCs during obesity, before after 1 month supplementation w-3 FA. We performed a case-control twelve women normal BMI (lean group) 19 grade 2 obesity (obese group), followed by...
Pecans (Carya illinoinensis) are considered a functional food due to the high content of polyunsaturated fatty acids, dietary fiber and polyphenols. To determine effect whole pecans (WP) or pecan polyphenol (PP) extract on development metabolic abnormalities in mice fed high-fat (HF) diet, we C57BL/6 with Control diet (7% fat), HF (23% containing 30% WP an supplemented 3.6 6 mg/g PP for 18 weeks. Supplementation reduced fat mass, serum cholesterol, insulin HOMA-IR by 44, 40, 74 91%,...
Childhood obesity increases the risk of developing metabolic diseases in adulthood, since environmental stimuli during critical windows development can impact on adult health. Studies demonstrating effect prepubertal diet disease are still limited. We hypothesized that a control (CD) protects phenotype from diet-induced (DIO), while high-fat (HFD) would predispose to alterations. Sprague-Dawley male rats were fed either CD or HFD period (day 30–40 age) and subsequently chronic CD,...
Excess amino acids from a protein-rich diet are mainly catabolized in the liver. However, it is still unclear to what extent gut microbiota may be involved mechanisms governing this catabolism. Therefore, aim of study was investigate whether consumption different dietary protein concentrations induces changes taxonomy microbiota, which contribute regulation hepatic acid Consumption high-protein caused overexpression HIF-1α colon and increase mitochondrial activity, creating more anaerobic...
The prevalence of type 2 diabetes (T2D) has increased significantly over the past three decades, with an estimated 30–40% cases remaining undiagnosed. Brown and beige adipose tissues are known for their remarkable catabolic capacity, ability to diminish blood glucose plasma concentration. Beige tissue can be differentiated from adipose-derived stem cells or through transdifferentiation white adipocytes. However, impact T2D progression on adipocytes' functional capacity remains unclear....