A5013754150- Circadian rhythm and melatonin
- Dietary Effects on Health
- Diet and metabolism studies
- Birth, Development, and Health
- Genetics, Aging, and Longevity in Model Organisms
- Adipose Tissue and Metabolism
- Sirtuins and Resveratrol in Medicine
- Tryptophan and brain disorders
- Obesity, Physical Activity, Diet
- Sleep and Wakefulness Research
- Calcium signaling and nucleotide metabolism
- Epigenetics and DNA Methylation
- Stress Responses and Cortisol
- Biochemical Acid Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Bioinformatics and Genomic Networks
- Treatment of Major Depression
- Metabolomics and Mass Spectrometry Studies
- Digestive system and related health
- Genetic Syndromes and Imprinting
- Cardiovascular Disease and Adiposity
- Autophagy in Disease and Therapy
National Institute of Genomic Medicine
2020-2025
Center for Research and Advanced Studies of the National Polytechnic Institute
2023-2025
Instituto de Medicina Genómica
2024
University of California, Irvine
2011-2018
Institut National de la Recherche Agronomique
2012
Nantes Université
2008-2010
PhysioPathologie des Adaptations Nutritionnelles
2008-2010
IMT Atlantique
2008
Significance Environmental and nutritional cues are crucial to determine genomic responses. They generally proceed through modulation of epigenetic mechanisms. Nuclear sirtuin 1 (SIRT1) is a well-known modifier, because it deacetylates histones, nutrient sensor, its enzymatic activity coupled hydrolysis NAD + . Compartmentalization metabolism makes difficult predict the pace -dependent reactions in cells. Here, we use nonlinear optics live cells define subnuclear distribution free bound...
Adipocytes are the main cell type in adipose tissue, which is a critical regulator of metabolism, highly specialized storing energy as fat. differentiate from multipotent mesenchymal stromal cells (hMSCs) through adipogenesis, tightly controlled differentiation process involving close interplay between metabolic transitions and sequential programs gene expression. However, specific gears driving this remain largely obscure. Additionally, metabolite nicotinamide adenine dinucleotide (NAD+)...
Abstract Early malnutrition has been associated with a high risk of developing obesity, diabetes and cardiovascular diseases in adulthood. In animals, poor perinatal nutrition produces hyperphagia persistent increased levels serotonin (5‐HT) the brain. Inasmuch as 5‐HT is directly related to negative regulation food intake, here we have investigated whether anorexic effects are altered by protein malnutrition. Pregnant Sprague‐Dawley rats were fed ad libitum either control (20% protein) or...
Background Nutrient deficiency during perinatal development is associated with an increased risk to develop obesity, diabetes and hypertension in the adulthood. However, molecular mechanisms underlying developmental programming of metabolic syndrome remain largely unknown. Methodology/Principal Findings Given essential role hypothalamus integration nutritional, endocrine neuronal cues, here we have analyzed profile transcriptome 180 days-old rats born dams fed either a control (200 g/kg) or...
Abstract Circadian rhythms govern homeostasis and organism physiology. Nutritional cues act as time givers, contributing to the synchronization between central peripheral clocks. Neuronal food-synchronized clocks are thought reside in hypothalamic nuclei such ventromedial hypothalamus (VMH) dorsomedial or extrahypothalamic brain areas nucleus accumbens. Interestingly, metabolic sensor of nicotinamide adenine dinucleotide-dependent deacetylase sirtuin-1 (SIRT1) is highly expressed VMH was...
The prevalence of type 2 diabetes (T2D) has increased significantly over the past three decades, with an estimated 30–40% cases remaining undiagnosed. Brown and beige adipose tissues are known for their remarkable catabolic capacity, ability to diminish blood glucose plasma concentration. Beige tissue can be differentiated from adipose-derived stem cells or through transdifferentiation white adipocytes. However, impact T2D progression on adipocytes' functional capacity remains unclear....
Abstract The circadian clock is an endogenous time-tracking system that anticipates daily environmental changes. Misalignment of the can cause obesity, which accompanied by reduced levels clock-controlled, rhythmic metabolite NAD + . Increasing becoming a therapy for metabolic dysfunction; however, impact fluctuations remains unknown. Here, we demonstrate time-of-day determines efficacy treatment diet-induced disease in mice. prior to active phase obese male mice ameliorated markers...
Abstract Hypothalamic circuits compute systemic information to control metabolism. Astrocytes residing within the hypothalamus directly sense nutrients and hormones, integrating metabolic information, modulating neuronal responses. Nevertheless, role of astrocytic circadian clock on energy balance remains unclear. We used mice with a targeted ablation core‐clock gene Bmal1 Gfap ‐expressing astrocytes gain insight played by this transcription factor in astrocytes. While mutation does not...
Over the past century, age-related diseases, such as cancer, type-2 diabetes, obesity, and mental illness, have shown a significant increase, negatively impacting overall quality of life. Studies on aged animal models unveiled progressive discoordination at multiple regulatory levels, including transcriptional, translational, post-translational processes, resulting from cellular stress circadian derangements. The clock emerges key regulator, sustaining physiological homeostasis promoting...
<title>Abstract</title> The prevalence of type 2 diabetes (T2D) has increased significantly over the past three decades, with an estimated 30-40% cases remaining undiagnosed. Brown and beige adipose tissues, known for their remarkable catabolic capacity, can lower blood glucose levels. Beige tissue be differentiated from stem cells or through transdifferentiation white tissue. However, impact T2D progression on adipocyte functional capacity remains unclear. Transcriptomic profiling...