A5073216233- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Sirtuins and Resveratrol in Medicine
- Exercise and Physiological Responses
- Circadian rhythm and melatonin
- Mitochondrial Function and Pathology
- Lipid metabolism and biosynthesis
- Muscle metabolism and nutrition
- Diet and metabolism studies
- Regulation of Appetite and Obesity
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Neurobiology and Insect Physiology Research
- Dietary Effects on Health
- Genetics, Aging, and Longevity in Model Organisms
- Endoplasmic Reticulum Stress and Disease
- Liver Disease Diagnosis and Treatment
- Light effects on plants
- Metabolism, Diabetes, and Cancer
- Cardiovascular Disease and Adiposity
- Pharmacological Effects and Assays
- Stress Responses and Cortisol
- Pancreatic function and diabetes
- Signaling Pathways in Disease
- Retinoids in leukemia and cellular processes
Novo Nordisk Foundation
2015-2025
University of Copenhagen
2015-2025
University of Southern Denmark
2021-2024
Odense Municipality
2024
Foundation Center
2020-2024
Novo Nordisk Foundation Center for Basic Metabolic Research
2020-2024
University Hospital Heidelberg
2023
Heidelberg University
2023
ASIT Biotech (Belgium)
2022
University of Pennsylvania
2013-2014
Cancer cells exhibit an aberrant metabolism that facilitates more efficient production of biomass and hence tumor growth progression. However, the genetic cues modulating this metabolic switch remain largely undetermined. We identified a function for promyelocytic leukemia (PML) gene, uncovering unexpected role bona fide suppressor in breast cancer cell survival. found PML acted as both negative regulator PPARγ coactivator 1A (PGC1A) acetylation potent activator PPAR signaling fatty acid...
The ribotoxic stress response (RSR) is a signaling pathway in which the p38- and c-Jun N-terminal kinase (JNK)-activating mitogen-activated protein (MAP3K) ZAKα senses stalling and/or collision of ribosomes. Here, we show that reactive oxygen species (ROS)-generating agents trigger ribosomal impairment activation. Conversely, zebrafish larvae deficient for are protected from ROS-induced pathology. Livers mice fed ROS-generating diet exhibit ZAKα-activating changes elongation dynamics....
Activation of energy expenditure in thermogenic fat is a promising strategy to improve metabolic health, yet the dynamic processes that evoke this response are poorly understood. Here we show synthesis mitochondrial phospholipid cardiolipin indispensable for stimulating and sustaining function. Cardiolipin biosynthesis robustly induced brown beige adipose upon cold exposure. Mimicking through overexpression synthase (Crls1) enhances consumption mouse human adipocytes. Crls1 deficiency...
Neutrophils provide first line of host defense against bacterial infections utilizing glycolysis for their effector functions. How and its major byproduct lactate are triggered in bone marrow (BM) neutrophils contribution to neutrophil mobilization acute inflammation is not clear. Here we report that lipopolysaccharides (LPS) or Salmonella Typhimurium triggers release by increasing glycolysis, NADPH-oxidase-mediated reactive oxygen species HIF-1α levels BM neutrophils. Increased...
Exercise training is a powerful means to combat metabolic diseases. Mice are extensively used investigate the benefits of exercise, but mild cold stress induced by ambient housing temperatures may confound translation humans. Thermoneutral strategy make mice more metabolically similar humans its effects on exercise adaptations unknown. Here we show that thermoneutral blunts exercise-induced improvements in insulin action muscle and adipose tissue reduces energy expenditure, body composition,...
Impairment of translation can lead to collisions ribosomes, which constitute an activation platform for several ribosomal stress-surveillance pathways. Among these is the ribotoxic stress response (RSR), where sensing by MAP3K ZAKα leads p38 and JNK kinases. Despite insights, physiological ramifications impairment downstream RSR signaling remain elusive. Here, we show that stalling ribosomes sufficient activate ZAKα. In amino acid deprivation full nutrient starvation, impacts on ensuing...
Specialized fat tissue generates heat and holds the potential to counter metabolic diseases.
Thermogenesis by uncoupling protein 1 (UCP1) is one of the primary mechanisms which brown adipose tissue (BAT) increases energy expenditure. UCP1 resides in inner mitochondrial membrane (IMM), where it dissipates potential independent adenosine triphosphate (ATP) synthase. Here, we provide evidence that phosphatidylethanolamine (PE) modulates UCP1-dependent proton conductance across IMM to modulate thermogenesis. Mitochondrial lipidomic analyses revealed PE as a signature molecule whose...