A5063526218- Renal cell carcinoma treatment
- Renal and related cancers
- Cancer Genomics and Diagnostics
- Bladder and Urothelial Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Multiple and Secondary Primary Cancers
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Nutrition and Health in Aging
- Urinary and Genital Oncology Studies
- Dialysis and Renal Disease Management
- Sarcoma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Global Cancer Incidence and Screening
- Body Composition Measurement Techniques
- Immune Cell Function and Interaction
- Cancer, Lipids, and Metabolism
- Urologic and reproductive health conditions
- Cutaneous Melanoma Detection and Management
- Genetic factors in colorectal cancer
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Pancreatic and Hepatic Oncology Research
- Cardiovascular Function and Risk Factors
University of Utah
2019-2025
Huntsman Cancer Institute
2019-2025
Kettering University
2023-2024
Memorial Sloan Kettering Cancer Center
2016-2024
University of Exeter
2024
Universidad Complutense de Madrid
2024
Cleveland Clinic Florida
2022-2024
The University of Texas at El Paso
2023-2024
Exelixis (United States)
2023
Bristol-Myers Squibb (Germany)
2023
Abstract Metastasis remains the main reason for renal cell carcinoma (RCC)–associated mortality. Tyrosine kinase inhibitors (TKI) impart clinical benefit most patients with RCC, but determinants of response are poorly understood. We report an integrated genomic and transcriptomic analysis metastatic clear RCC (ccRCC) treated TKI therapy identify predictors response. Patients in COMPARZ phase III trial received first-line sunitinib or pazopanib comparable efficacy. RNA-based analyses revealed...
The NCCN Guidelines for Prostate Cancer Early Detection provide recommendations individuals with a prostate who opt to participate in an early detection program after receiving the appropriate counseling on pros and cons. These Insights summary of recent updates regard testing protocol, use multiparametric MRI, management negative biopsy results optimize clinically significant cancer minimize indolent disease.
Thermogenesis by uncoupling protein 1 (UCP1) is one of the primary mechanisms which brown adipose tissue (BAT) increases energy expenditure. UCP1 resides in inner mitochondrial membrane (IMM), where it dissipates potential independent adenosine triphosphate (ATP) synthase. Here, we provide evidence that phosphatidylethanolamine (PE) modulates UCP1-dependent proton conductance across IMM to modulate thermogenesis. Mitochondrial lipidomic analyses revealed PE as a signature molecule whose...
Abstract Introduction Most studies on body composition in kidney cancer have been conducted among patients with metastatic disease. Given that aggressive tumours can adversely impact and even non‐metastatic be aggressive, we evaluated associations between pre‐surgical features tumour pathological clear cell renal (ccRCC). Methods The Resolve Cohort consists of 1239 ccRCC who underwent nephrectomy at Memorial Sloan Kettering Cancer Center 2000 2020. cross‐sectional areas radiodensities...
Translocation renal cell carcinoma (tRCC) is a rare, aggressive (RCC) subtype. There currently limited understanding on the role of molecular alterations in pathogenesis and progression these tumors. We investigated association between somatic clinical outcomes two independent cohorts profiled using DNA sequencing.
TFEB is overexpressed in -rearranged renal cell carcinomas as well tumors with amplifications of at 6p21.1. As recent literature suggests that 6p21.1 amplification behave more aggressively than those rearrangements , we compared relative gene expression these tumors. This study included 37 -altered tumors: 15 6p21.1-amplified and 22 (including 5 cases from The Cancer Genome Atlas data set). status was verified using a combination fluorescent situ hybridization (n=27) or comprehensive...
38 Background: In a subset of patients with molecular-imaging defined recurrent oligometastatic prostate cancer (PCa), salvage oligometastatectomy surgery and/or radiation may provide improved androgen deprivation therapy (ADT)-free survival. Methods: This is phase II trial oligorecurrent PCa after primary prostatectomy or detected on Axumin (n=11) Prostate-Specific Membrane Antigen (PSMA) (n=9) positron emission tomography. Oligometastatic disease was as ≤ 10 total sites, either lymph node...
Background Muscle-invasive urothelial cancer (UC) has a high risk of recurrence after definitive treatment. Nivolumab adjuvant to radical surgery improves disease-free survival in patients with UC recurrence; however, its role chemoradiation therapy (CRT) is unknown. Methods The NEXT trial single-arm, phase-2 study evaluating the efficacy and tolerability nivolumab CRT localized or locoregional UC. primary endpoint failure-free (FFS) at 2 years. Secondary endpoints include patterns...
Abstract Purpose: High body mass index (BMI) may lead to improved immune-checkpoint blockade (ICB) outcomes in metastatic clear cell renal carcinoma (mccRCC). However, BMI is a crude size measure. We investigated and radiographically assessed composition (BC) parameters association with mccRCC ICB outcomes. Experimental Design: Retrospective study of ICB-treated patients mccRCC. BC variables [skeletal muscle (SMI) multiple adiposity indexes] were determined using pretreatment CT scans....
No AccessJournal of UrologyAdult Urology1 Aug 2018Cystic Renal Cell Carcinoma: A Report on Outcomes Surgery and Active Surveillance in Patients Retrospectively Identified Pretreatment Imaging Mahyar Kashan, Mazyar Ghanaat, Andreas M. Hötker, Cihan Duzgol, Alejandro Sanchez, Renzo G. DiNatale, Kyle A. Blum, Maria F. Becerra, Brandon J. Manley, Jozefina Casuscelli, Michael Chiok, Jonathan Coleman, Paul Russo, Satish K. Tickoo, Oguz Akin, Ari Hakimi KashanMahyar Kashan Urology Service,...
Abstract Background Few studies have evaluated mental health disorders comprehensively among patients with prostate cancer on long-term follow-up. The primary aim of our study was to assess the incidence compared a general population cohort. A secondary investigate potential risk factors for cancer. Methods Cohorts 18 134 adenocarcinomas diagnosed between 2004 and 2017 73470 men without matched age, birth state, follow-up time were identified. Mental diagnoses identified from electronic...
Abstract Today, the major challenge in reservoir characterization is integrating data coming from different sources varying scales, order to obtain an accurate and high-resolution model. The role of seismic this integration often limited providing a structural model for reservoir. Its relatively low resolution usually limits its further use. However, areal coverage availability suggest that it has potential valuable more detailed studies through process inversion. In paper, novel intelligent...
Smart grids have been proposed as a mechanism to modernize energy grids. In smart grid, sensors, computers and communication networks are integrated into the power network. As number of sensors ability collect large amounts data increases, big analysis techniques required support decision making. This paper discusses challenges in context illustrates practical scenario visualizing diverse sources.
Background . Leiomyosarcomas (LMS) represent a heterogeneous subset of soft tissue sarcomas. Factors influencing prognosis for patients with metastatic extrauterine LMS (euLMS) are not well described. Limited data available regarding responses to systemic therapy. Methods We collected clinical and pathologic information all euLMS seen at Memorial Sloan Kettering Cancer Center between 1989 2012. Objective first-line therapy were analyzed baseline on-treatment imaging using RECIST 1.1. Results...
This study investigates a real-world multicenter cohort of patients with urinary tract cancer (UTC), primary disease sites including the bladder, urethra, and upper tract, who enrolled for research molecular testing their germline tumor. The purpose this was to evaluate factors that could affect likelihood identifying clinically actionable pathogenic variant (PV).
Abstract Background: Body composition may be related to survival in patients with clear-cell renal cell carcinoma (ccRCC), but studies have not simultaneously considered adipose and muscle tissue quantity radiodensity. Methods: We analyzed data from 1,022 ccRCC who underwent nephrectomy between 2000 2020 at Memorial Sloan Kettering Cancer Center. Skeletal muscle, visceral tissue, subcutaneous indexes (cm2/m2) radiodensities [Hounsfield units (HU)] were assessed noncontrast presurgical CT...