A5034814142- Renal cell carcinoma treatment
- Renal and related cancers
- Cancer Genomics and Diagnostics
- Testicular diseases and treatments
- Cancer Immunotherapy and Biomarkers
- Sarcoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cancer Diagnosis and Treatment
- Dental materials and restorations
- Neuroblastoma Research and Treatments
- Heart Rate Variability and Autonomic Control
- Complex Systems and Time Series Analysis
- Quantum Chromodynamics and Particle Interactions
- Bladder and Urothelial Cancer Treatments
- Multiple and Secondary Primary Cancers
- Genetic and Kidney Cyst Diseases
- Dialysis and Renal Disease Management
- Particle physics theoretical and experimental studies
- Nuclear physics research studies
- Epigenetics and DNA Methylation
- Brain Metastases and Treatment
- Neonatal Health and Biochemistry
- Cardiac and Coronary Surgery Techniques
- High-Energy Particle Collisions Research
- Infant Nutrition and Health
Memorial Sloan Kettering Cancer Center
2018-2025
University of Zagreb
2001-2024
Kettering University
2020-2023
New York Structural Biology Center
2023
Emory University
2010-2022
Creative Commons
2022
Cornell University
2021
Artificial Intelligence in Medicine (Canada)
2020
Bridge University
2020
Software (Spain)
2020
<h3>Importance</h3> Data regarding the contribution of red blood cell (RBC) transfusion and anemia to necrotizing enterocolitis (NEC) are conflicting. These associations have not been prospectively evaluated, accounting for repeated, time-varying exposures. <h3>Objective</h3> To determine relationship between RBC transfusion, severe anemia, NEC. <h3>Design, Setting, Participants</h3> In a secondary, prospective, multicenter observational cohort study from January 2010 February 2014, very...
Factors contributing to hematopoietic recovery following chimeric antigen receptor (CAR) T-cell therapy have not been well studied. In an analysis of 83 patients with hematologic malignancies treated CAR therapy, we describe patterns and evaluate potentially associated factors. We included who received axicabtagene ciloleucel (n = 30) or tisagenlecleucel 10) for B-cell lymphoma, CD19-28z T acute lymphoblastic leukemia (NCT01044069; n 37), maturation targeting cells multiple myeloma...
Information on the size and shape of neutron skin (208)Pb is extracted from coherent pion photoproduction cross sections measured using Crystal Ball detector together with Glasgow tagger at MAMI electron beam facility. On exploitation an interpolated fit a theoretical model to sections, half-height radius diffuseness distribution are found be c(n)=6.70±0.03(stat.) fm a(n)=0.55±0.01(stat.)(-0.03)(+0.02)(sys.) fm, respectively, corresponding thickness...
PURPOSE To assess the efficacy and safety of cabozantinib plus nivolumab in a phase II trial patients with non–clear-cell renal cell carcinoma (RCC). PATIENTS AND METHODS Patients had advanced who underwent 0-1 prior systemic therapies excluding immune checkpoint inhibitors. received 40 mg once daily 240 every 2 weeks or 480 4 weeks. Cohort 1 enrolled papillary, unclassified, translocation-associated RCC; cohort chromophobe RCC. The primary end point was objective response rate (ORR) by...
To ensure an adequate clinical composite filling light source for photopolymerization is of great importance. In everyday conditions commonly used unit polymerization material halogen curing unit. The development new blue superbright emitting diodes (LED) 470 nm wavelengths comes as alternative to standard 450-470 wavelengths. purpose this study was compare the degree conversion (DC) and temperature rise four hybrid materials: Tetric Ceram, Pertac II, Valux Plus Degufill Mineral during 40 s...
This study analyzed the degree of conversion, temperature increase and polymerization shrinkage two hybrid composite materials polymerized with a halogen lamp using three illumination modes photopolymerization device based on blue light emitting diodes. The conversion Tetric Ceram (TC) (Ivoclar Vivadent) Filtek Z 250 (F) (3M/ESPE) was measured by Fourier transformation infrared spectroscopy at surface 2-mm depth; rise digital multimeter, linear during cure laser interferometry. Composite...
Identification of patients with hereditary renal cell carcinoma (RCC) is important for cancer screening and, in advanced disease, guiding treatment. The prevalence cancer-related germline mutations RCC and the phenotypes associated some rare are unknown.To examine both known predisposition genes other cancer-associated to identify clinical pathologic factors mutations.In this cohort study conducted from October 1, 2015, July 31, 2017, 254 267 (American Joint Committee on Cancer stage III or...
Postnatal cytomegalovirus (CMV) infection can cause serious morbidity and mortality in very low-birth-weight (VLBW) infants. The primary sources of postnatal CMV this population are breast milk blood transfusion. current risks attributable to these vectors, as well the efficacy approaches prevent transmission, poorly characterized. To estimate risk transmission from 2 sources: (1) transfusion CMV-seronegative leukoreduced (2) maternal milk. A prospective, multicenter birth-cohort study was...
HIV infection is associated with high rates of osteopenia and osteoporosis, but the mechanisms involved are unclear. We recently reported that bone loss in transgenic rat model was upregulation B cell expression key osteoclastogenic cytokine receptor-activator NF-κB ligand (RANKL), compounded by a simultaneous decline its physiological moderator, osteoprotegerin (OPG). To clinically translate these findings we performed cross-sectional immuno-skeletal profiling HIV-uninfected antiretroviral...
Abstract Purpose: KRAS mutations are identified in approximately 30% of patients with non–small cell lung cancer (NSCLC). Novel direct inhibitors G12C have shown activity early-phase clinical trials. We hypothesized that may distinct characteristics and responses to therapies. Experimental Design: Through routine next-generation sequencing, we KRAS-mutant NSCLC treated at Memorial Sloan Kettering Cancer Center (New York, NY) from 2014 2018 reviewed tumor characteristics, overall survival,...
Urothelial cancers (UCs) have a substantial hereditary component, but, other than their association with Lynch syndrome, the contribution of genetic risk factors to UC pathogenesis has not been systematically defined. We sought determine prevalence pathogenic/likely pathogenic (P/LP) germline variants in patients and identify associated clinical factors.Overall, 586 underwent prospective, matched tumor-normal DNA sequencing. Seventy-seven genes cancer predisposition were analyzed; allele...
Abstract Purpose: Fumarate hydratase–deficient renal cell carcinoma (FH-RCC) is a rare, aggressive form of RCC associated with hereditary leiomyomatosis and syndrome. Evidence for systemic therapy efficacy lacking. Experimental Design: We studied clinical genomic characteristics FH-RCC, including response [objective rate (ORR)] to therapies next-generation sequencing (NGS). Patients metastatic defined by presence pathogenic germline or somatic FH mutation plus IHC evidence loss, were...
The unavoidable consequence of composite resin photopolymerization is temperature rise in tooth tissue. depends not only on the illumination time, but also light intensity, distance guide tip from surface, composition and shade thickness. most commonly used units for polymerization today are halogen curing units, which emit a large spectrum wavelengths. A proportion has no influence degree conversion therefore causes unnecessary rise. Units based source - blue emitting diodes (LED), as an...
The objective of this study was to evaluate the degree conversion and temperature rise in three different composite materials when illuminated by an experimental light source [blue superbright emitting diodes (LEDs)] compared with plasma traditional photopolymerization unit. were measured using Fourier transform infrared (FTIR) spectroscopy digital multimeter, respectively. results revealed significantly higher values case conventional curing than other two sources whereas lower blue LEDs...
The objective was to compare the resolution of organ dysfunction, 28-day mortality, and biochemical markers in children with thrombocytopenia-associated multiple failure who received therapeutic plasma exchange versus no exchange.Observational longitudinal cohort study.Nine U.S. PICUs.Eighty-one sepsis-induced failure.Therapeutic exchange.Adjusted relative risk for mortality modeled using standard multivariate regression propensity score weighting reduce covariate confounding. Change from...
Abstract Introduction Most studies on body composition in kidney cancer have been conducted among patients with metastatic disease. Given that aggressive tumours can adversely impact and even non‐metastatic be aggressive, we evaluated associations between pre‐surgical features tumour pathological clear cell renal (ccRCC). Methods The Resolve Cohort consists of 1239 ccRCC who underwent nephrectomy at Memorial Sloan Kettering Cancer Center 2000 2020. cross‐sectional areas radiodensities...
Background Loss-of-function alterations in DNA damage repair (DDR) genes are associated with human tumorigenesis and may determine benefit from immune-oncology (I/O) agents as shown colon cancer. However, biologic significance relevance to I/O metastatic clear cell RCC (ccRCC) unknown. Methods Genomic data treatment outcomes were retrospectively collected for patients ccRCC. Tumor germline subject targeted next generation sequencing across >400 of interest, including 34 DDR genes....
4509 Background: Cabozantinib plus nivolumab (CaboNivo) improved objective response rate (ORR), progression-free survival (PFS), and overall (OS) over sunitinib in a phase 3 trial for metastatic clear cell renal carcinoma (RCC). (Choueiri, abstract 6960, ESMO 2020) We report the results of 2 CaboNivo patients (pts) with non-clear RCC. Methods: Pts had advanced RCC, 0 or 1 prior systemic therapies excluding immune checkpoint inhibitors, measurable disease by RECIST. Cabo 40 mg/day Nivo 240 mg...
Primary surgical treatment with retroperitoneal lymph node dissection aims to accurately stage and treat patients node-positive pure seminoma while avoiding long-term risks of chemotherapy or radiation, traditional standard-of-care treatments.
In Brief BACKGROUND: Monitoring heparin concentration along with the activated clotting time (ACT) may provide a more accurate guide for administration of to infants during cardiopulmonary bypass (CPB). However, standard laboratory assays (antifactor Xa concentration) require plasma instead whole blood, and results are not immediately available clinicians. Alternatively, measurements blood be performed at bedside using an automated protamine titration device, Hepcon instrument (Hepcon...
Human immunodeficiency virus (HIV) infection and antiretroviral therapy (ART) are associated with bone loss leading to increased fracture rate among HIV-infected individuals. ART-induced is most intense within the first 48 weeks of therapy, providing a window for prophylaxis long-acting antiresorptives.In phase 2, double-blind, placebo-controlled trial, we randomized 63 nonosteoporotic, ART-naive adults HIV initiating ART atazanavir/ritonavir + tenofovir/emtricitabine single zoledronic acid...