A5020145667- HIV-related health complications and treatments
- HIV/AIDS Research and Interventions
- Cervical Cancer and HPV Research
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- HIV, Drug Use, Sexual Risk
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 Clinical Research Studies
- Bone and Joint Diseases
- Colorectal and Anal Carcinomas
- Adolescent Sexual and Reproductive Health
- Viral-associated cancers and disorders
- Bone health and treatments
- Biochemical and Molecular Research
- Medication Adherence and Compliance
- Blood Pressure and Hypertension Studies
- COVID-19 and Mental Health
- Maternal Mental Health During Pregnancy and Postpartum
- COVID-19 epidemiological studies
- Vitamin D Research Studies
- Oral microbiology and periodontitis research
- HIV/AIDS oral health manifestations
- Pharmacological Effects and Toxicity Studies
- Long-Term Effects of COVID-19
- Head and Neck Cancer Studies
Emory University
2016-2025
Grady Memorial Hospital
2015-2024
Grady Health System
2016-2022
GTx (United States)
2018
Cecil College
2018
University of Florida
2016
Princeton University
2016
Integrase strand-transfer inhibitor (INSTI)-based antiretroviral therapy (ART) is recommended for human immunodeficiency virus (HIV) management. Although studies have suggested associations between INSTIs and weight gain, women living with HIV (WLHIV) been underrepresented in research. We evaluated the effect of switching or adding among WLHIV.Women enrolled Women's Interagency Study (WIHS) from 2006-2017 who switched to added an INSTI ART (SWAD group) were compared on non-INSTI (STAY...
Antiretroviral therapy (ART) paradoxically intensifies bone loss in the setting of HIV infection. Although extent varies, it occurs with virtually all ART types, suggesting a common pathway that may be aligned disease reversal. Using an animal model immunodeficiency we recently demonstrated immune activation associated CD4 T-cell reconstitution induces increased production osteoclastogenic cytokines RANKL and TNFα by cells, driving enhanced resorption mineral density.To confirm these...
Integrase strand transfer inhibitors (INSTIs) have been associated with weight gain among women living HIV. We aimed to investigate the association between INSTIs and change in cardiometabolic risk indicators.
Abstract Background: Effective screening for oropharyngeal cancer is lacking. Four oncogenic HPV clearance definitions were explored to understand long-term natural history persistent oral (oncHPV), the precursor of cancer. Methods: Prospective multicenter cohort participants living with/at-risk HIV, with rinse and gargle samples collected every 6 12 months up 10 years tested oncHPV. included 1 (clear1), 2 (clear2), 3 (clear3) consecutive negatives, or being negative at last two visits...
There are limited data describing the presenting characteristics and outcomes among US persons with HIV (PWH) requiring hospitalization for coronavirus disease 2019 (COVID-19).We performed a case series of all PWH sequentially admitted COVID-19 from 8 March 2020 to 23 April at three hospitals in Atlanta, Georgia. Sociodemographic, clinical HIV-associated were collected.Of 530 confirmed cases hospitalized during this period, 20 occurred (3.8%). The median age was 57 (Q1-Q3, 48-62) years, 65%...
Human immunodeficiency virus (HIV) infection and antiretroviral therapy (ART) are associated with bone loss leading to increased fracture rate among HIV-infected individuals. ART-induced is most intense within the first 48 weeks of therapy, providing a window for prophylaxis long-acting antiresorptives.In phase 2, double-blind, placebo-controlled trial, we randomized 63 nonosteoporotic, ART-naive adults HIV initiating ART atazanavir/ritonavir + tenofovir/emtricitabine single zoledronic acid...
The impact of integrase strand-transfer inhibitors (INSTIs) on steatotic liver disease in women with HIV (WWH) is unknown. Using data collected the Women's Interagency Study from 2007-2020, change Fibrosis-4 index (FIB4), aspartate aminotransferase to platelet ratio (APRI), and non-alcoholic fatty fibrosis score (NFS) over 5 years was compared between virologically-suppressed WWH who switched or added an INSTI their antiretroviral therapy (ART) remaining non-INSTI ART. In participants...
OBJECTIVES: Longitudinal studies with biospecimen collection are rich for pharmacokinetics (PK)-adverse effects analyses but may lack time-after-dose (TAD). Using dolutegravir (DTG) PK and TAD in women (Women’s Interagency HIV Study; WIHS), we developed a novel method to infer men (Multicenter AIDS Cohort MACS), which never collected TAD. METHODS: We observed trimodal distribution WIHS on DTG, each of the 3 components characterized by mean, scale, shape parameters skew-normal distribution....
Abstract Background The HIV‐1 reservoir in CD4+ T cells (HR CD4 ) pose a major challenge to curing HIV, with many of its mechanisms still unclear. DNA integration and immune responses may alter the host's epigenetic landscape, potentially silencing replication. Methods This study used bisulphite capture methylation sequencing from blood 427 virally suppressed women HIV identify differentially methylated sites regions associated HR . Results average total size was 1409 copies per million...
Objectives/Goals: To assess the association between integrase strand-transfer inhibitor (INSTI) use and sarcopenia, pre-frailty, frailty in people living with HIV (PLWH) compared to non-INSTI users HIV-seronegative controls, focusing on changes muscle strength, function, physical activity over time. Methods/Study Population: We analyzed data from MACS/WIHS Combined Cohort Study (CCS) as part of SPPACE INSTI Study. Eligible participants were PLWH ART for ≥2 years or individuals at risk HIV,...
Childhood maltreatment and HIV are both associated with a greater risk for adverse mental health, including posttraumatic stress disorder (PTSD), depression, increased systemic inflammation. However, it remains unknown whether childhood interact to exacerbate PTSD, inflammation in manner that may further increase the of health outcomes people living HIV. This study investigated interaction between status on PTSD depression symptom severity, peripheral concentrations lipopolysaccharide (LPS)...
Background SARS-CoV-2 infection among People Living With HIV (PLWH) is not well-described.Objective To study COVID-19 symptoms and PCR-based swab testing participants of the Multicenter AIDS Cohort Study (MACS) Women's Interagency (WIHS).Methods A telephone survey was collected April-June 30, 2020. Symptom prevalence were explored. Multivariable logistic regression used to examine factors associated with positivity.Results The completed by 3411 participants, including 2078 (61%) PLWH 1333...
Objective: Diabetes mellitus (DM) is associated with lower antiretroviral (ART) drug exposure among persons HIV (PWH) compared to PWH without DM. The association between DM and virologic control in PWH, however, remains unknown. Methods: We included participants the Multicenter AIDS Cohort Study/Women's Interagency Study Combined (MWCCS) who had initiated ART 1999 2020 a suppressed viral load (≤200 copies/ml) within 1 year of initiation. frequency incident viremia (HIV-1 RNA >200 adult...
Weight and body mass index (BMI) change was assessed among women after switch to integrase inhibitors (INSTIs) and/or tenofovir alafenamide (TAF). From 2006 2019, 1,458 living with HIV enrolled in the Women's Interagency Study on antiretroviral therapy (ART) ≥1 study visit before switching INSTIs TAF were included. BMI compared pre- postswitch INSTI (by class type) using multivariable linear mixed effects models; all models also stratified by preswitch presence or absence of obesity (BMI ≥30...
The COVID-19 pandemic has exposed longstanding vulnerabilities in our healthcare system, and laid bare the individuals communities most threatened by insufficient public health support. In United States, persons with HIV (PWH) represent a heterogenous population complex medical sociobehavioral needs currently unmet systemically flawed care models [1,2]. Thriving on disparity, devastates same where prevalence is highest [3], illuminating catastrophic synergy of poverty, policies, structural...
We explored experiences with telemedicine among persons HIV (PWH) during the first wave of coronavirus disease 2019 (COVID-19) pandemic. A convenience sample adults (>18 years) receiving care in an urban clinic Atlanta were invited to participate. Patients completed a structured survey that assessed usefulness, quality, satisfaction, and concerns services (telephone calls) received COVID-19 pandemic (March-May 2020). Demographic, plasma HIV-1 RNA, CD4+ T cell count data obtained through...
Cocaine-one of the most frequently abused illicit drugs among persons living with HIV [people (PLWH)]-slows decline viral production after antiretroviral therapy and is associated higher load, more rapid progression, increased mortality.
Abstract Background Sex-specific, long-term, body weight change in persons with human immunodeficiency virus (PWH) following switch to regimens containing integrase strand transfer inhibitors (INSTIs) is unknown. Methods We compared PWH enrolled the MACS/WIHS Combined Cohort Study (2007–2020) who switched/added an INSTI their antiretroviral therapy (ART) regimen those remaining on non-INSTI ART and people without (PWOH), by sex. Follow-up time was since visit (or comparable controls). Linear...
Abstract Background Integrase strand transfer inhibitors (INSTIs) and the menopausal transition have been associated with body composition changes in women human immunodeficiency virus (WWH), but their interaction is unknown. Methods From 2006 to 2019, 1131 virally-suppressed WWH (419 who switched INSTI [INSTI+]; 712 did not switch [INSTI–]) 887 without HIV (WWOH) from Women's Interagency Study were included. Mixed-effects models used evaluate change waist circumference (WC) mass index (BMI)...