A5061190763- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Liver Disease and Transplantation
- HIV-related health complications and treatments
- Hepatitis B Virus Studies
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- HIV, Drug Use, Sexual Risk
- Hepatitis Viruses Studies and Epidemiology
- Liver Diseases and Immunity
- Renal Transplantation Outcomes and Treatments
- Pancreatitis Pathology and Treatment
- Food Security and Health in Diverse Populations
- Reproductive System and Pregnancy
- Reproductive Physiology in Livestock
- Organ Transplantation Techniques and Outcomes
- Gut microbiota and health
- Immune Response and Inflammation
- Folate and B Vitamins Research
- Telemedicine and Telehealth Implementation
- Diet, Metabolism, and Disease
- Gestational Diabetes Research and Management
- Tryptophan and brain disorders
- Diet and metabolism studies
University of California, San Francisco
2016-2025
University of San Francisco
2015-2024
The Royal Free Hospital
2019-2021
University College London
2019-2021
Swansea University
2012-2019
Johns Hopkins University
2006-2016
Johns Hopkins Medicine
2014-2016
Georgetown University Medical Center
2016
Georgetown University
2016
Rush University Medical Center
2016
The aim of this document is to provide a concise scientific review the currently available COVID-19 vaccines and those in development, including mRNA, adenoviral vectors, recombinant protein approaches. anticipated use patients with chronic liver disease (CLD) transplant (LT) recipients reviewed practical guidance provided for health care providers involved LT about vaccine prioritization administration. Pfizer Moderna mRNA are associated 94%-95% efficacy compared placebo against COVID-19....
The Infectious Diseases Society of America and the American Association for Study Liver have collaboratively developed evidence-based guidance regarding diagnosis, management, treatment hepatitis C virus (HCV) infection since 2013. A panel clinicians investigators with extensive infectious diseases or hepatology expertise specific to HCV periodically review evidence from field update existing recommendations introduce new as warrants. This focuses on changes previous 2020 published update,...
Human immunodeficiency virus (HIV) infection and antiretroviral therapy (ART) may increase the risk of fatty liver disease. We determined prevalence factors for by comparing HIV-infected men with HIV-uninfected who have sex in Multicenter AIDS Cohort Study (MACS).In 719 MACS participants consumed less than three alcoholic drinks daily, was defined as a liver-to-spleen attenuation ratio <1 on noncontrast computed tomography (CT). genotyped single nucleotide polymorphisms patatin-like...
Bacterial infections of the uterus or mammary gland commonly cause disease and infertility by perturbing growth steroidogenesis dominant follicle in ovary cattle. Cells innate immune system use Toll-like receptors TLR2, TLR4, TLR5 to recognize pathogen-associated molecular patterns (PAMPs) expressed bacteria, leading activation MAPK nuclear factor-κBκ pathways production inflammatory cytokines such as IL-1β IL-6, chemokine IL-8. The present study tested whether granulosa cells from follicles...
Summary Background Metabolic dysfunction‐associated steatotic liver disease (MASLD) has recently been proposed as a replacement term for NAFLD. Aims To assess the effects of this new nomenclature on prevalence and distribution different SLD categories in people with HIV (PWH) identified factors associated MASLD clinically significant fibrosis (CSF). Methods PWH were prospectively enrolled from 9 US centres underwent clinical evaluation vibration‐controlled transient elastography controlled...
Characterizing the genetically diverse HIV sequences that persist in reservoir despite antiretroviral therapy (ART) is critical to cure efforts. Our observations confirm proviruses persisting blood on ART, which are largely defective, broadly reflect extent of within-host evolution pre-ART. Moreover, on-ART clonal expansion not appreciably accompanied by loss distinct proviral lineages. In fact, genetic composition remained stable all but one participant, whom, after 12 years dating around...
Importance Injection drug use is the primary risk factor for hepatitis C virus (HCV) infection in adults. More than one-third of newly reported HCV cases occur women, particularly among persons aged 20 to 39 years. However, nationally representative data on during pregnancy are limited. Objective To estimate temporal trend HCV-positive pregnancies opioid epidemic and identify HCV-associated maternal perinatal outcomes. Design, Setting, Participants A cross-sectional study was performed with...
Background.Although liver disease commonly causes morbidity and mortality among human immunodeficiency virus (HIV)-infected individuals, data are limited on its prevalence in HIV monoinfection.We used the aspartate aminotransferase-to-platelet ratio index (APRI) as a surrogate marker of hepatic fibrosis to characterize Multicenter AIDS Cohort Study.Methods.Men were categorized based their viral hepatitis status: uninfected (n 5 1170), monoinfected 509), 74), HIV-viral coinfected...
The COVID‐19 pandemic has exposed healthcare inequities in the USA and highlighted importance of social conditions shaping health persons. In field hepatology, determinants (SDOH) are closely linked to disparities liver disease prevalence, outcomes, access treatment. economic disruption physical distancing policies brought on by have further exacerbated these disparities, may long‐lasting consequences for marginalized patients with chronic disease. There several ways that hepatology...
Abstract In this international, multicenter open-label study (ACTG A5379) of HepB-CpG vaccine in people with human immunodeficiency virus (HIV) without prior hepatitis B (HBV) vaccination, all 68 participants achieved HBV seroprotective titers after the 3-dose series primary analysis. No unexpected safety issues were observed.
Importance Disparities persist in testing and treatment for hepatitis C virus (HCV), leaving socially marginalized populations less likely to benefit from curative treatment. Linkage services are often insufficient overcome barriers navigating the medical system contextual factors. Objective To determine feasibility, acceptability, safety of HCV at point infection diagnosis disclosure a nonclinical community setting. Design, Setting, Participants In this single-arm nonrandomized controlled...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic among US children. Studies have associated food insecurity with MASLD in adults, but there are few studies of pediatric MASLD, particularly high-risk populations. We assessed impact household at 4 years age on Latinx
Summary Background Metabolic dysfunction‐associated steatotic liver disease (MASLD) is common in people with HIV (PWH). The morphological spectrum of MASLD compared to matched controls and the correlation between NAFLD activity score (NAS) fibrosis stage PWH remains unknown. Methods Overall, 107 biopsies from (MASLD‐PWH) were individuals without (MASLD controls) on age at biopsy, race/ethnicity, sex, type 2 diabetes, body mass index (BMI) alanine aminotransferase (ALT) level. Biopsies scored...
Abstract Background Disparities persist in testing and treatment for hepatitis C virus (HCV), leaving socially marginalized populations, including people who inject drugs (PWID), less likely to benefit from curative treatment. Linkage services are often insufficient overcome barriers navigating the medical system contextual factors. Methods The You’re Empowered Treatment Initiation (YETI) Partner trial is a single-site randomized controlled evaluating efficacy of two-session behavioral...
The impact of integrase strand-transfer inhibitors (INSTIs) on steatotic liver disease in women with HIV (WWH) is unknown. Using data collected the Women's Interagency Study from 2007-2020, change Fibrosis-4 index (FIB4), aspartate aminotransferase to platelet ratio (APRI), and non-alcoholic fatty fibrosis score (NFS) over 5 years was compared between virologically-suppressed WWH who switched or added an INSTI their antiretroviral therapy (ART) remaining non-INSTI ART. In participants...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is highly prevalent in people living with HIV. Gut microbial translocation and gut damage may play a role MASLD pathogenesis. We determined associations of circulating biomarkers hepatic steatosis fibrosis large US cohort women HIV (WWH) without Vibration controlled transient elastography (VCTE) was conducted from 2013-2018 among 854 WWH 349 Serum were measured within 6 months the VCTE: kynurenine to tryptophan (KT) ratio,...