A5038668692- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Liver Disease and Transplantation
- Transplantation: Methods and Outcomes
- Renal and Vascular Pathologies
- Liver Disease Diagnosis and Treatment
- HIV/AIDS Research and Interventions
- Polyomavirus and related diseases
- COVID-19 Clinical Research Studies
- COVID-19 Impact on Reproduction
- COVID-19 and healthcare impacts
- Grief, Bereavement, and Mental Health
- Healthcare Policy and Management
- Viral-associated cancers and disorders
- Palliative Care and End-of-Life Issues
- HIV/AIDS drug development and treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Hepatitis C virus research
- Emergency and Acute Care Studies
- Organ and Tissue Transplantation Research
- Cardiac, Anesthesia and Surgical Outcomes
- Abdominal vascular conditions and treatments
- Nonmelanoma Skin Cancer Studies
- Autoimmune and Inflammatory Disorders
New York University
2023-2025
NYU Langone Health
2024-2025
Miami Transplant Institute
2024
Johns Hopkins Medicine
2019-2023
Johns Hopkins University
2018-2023
Yale University
2023
University of Minnesota
2023
Washington University in St. Louis
2023
Winterthur Museum Garden and Library
2023
Angion (United States)
2023
We studied the safety and reactogenicity SARS-CoV-2 mRNA vaccines in transplant recipients because immunosuppressed patients were excluded from vaccine trials.US recruited into this prospective cohort study through social media; those who completed full series between December 9, 2020 March 1, 2021 included. collected demographics, medical history, information within 7 d after doses 1 2 (D1, D2). Associations characteristics reactions evaluated using modified Poisson regression.We 741...
Background Pre-liver transplant (LT) sarcopenia is associated with poor survival. Methods exist for measuring body composition use of CT scans; however, it unclear which components best predict post-LT outcomes. Purpose To quantify the association between abdominal CT-based measurements and mortality in a large North American cohort. Materials This was retrospective cohort adult first-time deceased-donor LT recipients from 2009 to 2018 who underwent pre-LT scans, including at L3 vertebral...
This study uses a national registry to characterize temporal trends in perioperative mortality donors and risk factors associated with this event.
ABSTRACT Introduction Some living organ donors will decide to donate again at a later date. Evidence has indicated that this practice may have increased in recent years. We evaluated the incidence and outcomes of inform counseling potential repeat donors. Methods Using SRTR data from 1994 2023, we identified 220 their 415 recipients. constructed donor comparison groups using weighting by odds. described clinical lab results 6 months, 1 year, 2 years post‐donation separately for kidney‐second...
ABSTRACT Purpose In October 2018, the OPTN changed adult heart transplant (HT) allocation policy, increasing number of candidates that had higher priority than pediatric candidates, potentially disadvantaging waitlist registrants. Methods To understand impact this policy change, we used SRTR data to identify 1469 pre‐policy (7/2016–9/2018) and 2901 (10/2018–12/2022) post‐policy (< 18 years) HT We quantified mortality risks using weighted cause‐specific hazard models, then competing...
Orthotopic heart transplantation is considered to be the best treatment for end-stage failure, with improved survival and quality of life patients.1 Despite number adult pediatric transplants performed in US having reached >4000 annually, patients waiting a allograft continues exceed available supply.2 Xenotransplantation has emerged as promising alternative address demand by providing source organs that readily practically inexhaustible.3 Given their anatomical physiological similarity...
Organ Procurement and Transplantation Network (OPTN) policy requires 2 years of follow-up for living kidney donors (LKDs); however, many transplant hospitals struggle to meet this requirement. We developed tested a mobile health (mHealth) system LKD in pilot randomized-controlled trial (RCT). LKDs were randomly assigned either the intervention (mHealth + standard care) or control arm (standard care). assessed OPTN policy-defined completeness timeliness 6-month, 1-year, 2-year follow-ups....
Infections remain a major threat to successful kidney transplantation (KT). To characterize the landscape and impact of post-KT infections in modern era, we used United States Renal Data System (USRDS) data linked Scientific Registry Transplant Recipients (SRTR) study 141 661 Medicare-primary transplant recipients from January 1, 1999 December 31, 2014. Infection diagnoses were ascertained by International Classification Diseases, Ninth Revision (ICD-9) codes. The cumulative incidence...
The first sustained increase in live kidney donation the United States 15 years was observed from 2017 to 2019. To help sustain this surge, we studied 35 900 donors (70.3% white, 14.5% Hispanic, 9.3% black, 4.4% Asian) understand 2017-2019 vs 2014-2016 using Poisson regression. Among biologically related aged <35, 35-49, and ≥50 years, number of did not change across race/ethnicity but increased by 38% 29% for Hispanic black ≥50. unrelated ≥50, white 18%, 14%, 27%; <35 22% 35% 35-49 ≥50;...
Prioritization of highly sensitized (HS) candidates under the kidney allocation system (KAS) and growth large, multicenter kidney-paired donation (KPD) clearinghouses have broadened transplant modalities available to HS candidates. To quantify temporal trends in utilization these modalities, we used SRTR data from 2009 2017 study 39 907 adult (cPRA ≥ 80%) waitlisted 19 003 recipients. We competing risks regression likelihood DDKT, KPD, non-KPD LDKT for (Era 1: January 1, 2009-December 31,...
Historically, deceased organ donation was lower among Black compared with White populations, motivating efforts to reduce racial disparities. The overarching effect of these in and other racial/ethnic groups remains unclear.To examine changes over time.This population-based cohort study used data from January 1, 1999, through December 31, 2017, the Scientific Registry Transplant Recipients quantify number actual donors, Centers for Disease Control Prevention Wide-ranging Online Data...
Kidney transplant (KT) candidates with HIV face higher mortality on the waitlist compared without HIV. Because Organ Policy Equity (HOPE) Act has expanded donor pool to allow donors (D + ), it is crucial understand whether this impacted rates for population.
Steatotic donor livers (SDLs) (macrosteatosis ≥30%) represent a possible pool expansion, but are frequently discarded due to historical association with mortality and graft loss. However, changes in recipient/donor demographics, allocation policy, clinical protocols might have altered utilization outcomes of SDLs. We used Scientific Registry Transplant Recipients data from 2005 2017 adjusted multilevel regression quantify temporal trends discard rates (logistic) posttransplant (Cox) SDLs,...
In March 2020, COVID-19 infections began to rise exponentially in the USA, placing substantial burden on healthcare system. As a result, there was rapid change transplant practices and policies, with cessation of most procedures. Our goal understand changes pediatric kidney transplantation (KT) at national level during epidemic.Using SRTR data, we examined waitlist registration, removal or inactivation, deceased donor living (DDKT/LDKT) events start disease transmission USA compared same...
Individuals considering living kidney donation face geographic, financial, and logistical challenges. Telemedicine can facilitate healthcare access/care coordination. Yet difficulties exist in telemedicine implementation sustainability. We sought to examine centers' practices providers' attitudes toward improve services for donors. surveyed multidisciplinary providers from 194 active adult US donor transplant centers; 293 128 unique centers responded the survey (center representation rate =...
Background. Donor livers with ≥30% macrosteatosis (steatotic livers) represent a possible expansion to the donor pool, but are frequently discarded as they associated an increased risk of mortality and graft loss. We hypothesized that there certain recipient phenotypes would tolerate steatosis well, therefore best suited receive these grafts. Methods. Using national registry data from Scientific Registry Transplant Recipients between 2006 2017, we compared 2048 liver transplant recipients...
Background. Transplant recipients with HIV may have worse outcomes coronavirus disease 2019 (COVID-19) due to impaired T-cell function coupled immunosuppressive drugs. Alternatively, immunosuppression might reduce inflammatory complications and/or antiretrovirals could be protective. Methods. Prospective reporting of all cases SARS-CoV-2 infection was required within the HOPE in Action Multicenter Consortium, a cohort kidney and liver transplant who received organs from donors without at 32...
The Kidney Allocation System (KAS) has resulted in fewer pediatric kidneys being allocated to deceased donor kidney transplant (pDDKT) recipients. This had prompted concerns that post-pDDKT outcomes may worsen. To study this, we used SRTR data compare the of 953 pre-KAS pDDKT (age <18 years) recipients (December 4, 2012-December 3, 2014) with 934 post-KAS 2014-December 2016). We analyzed mortality and graft loss by using Cox regression, delayed function (DGF) logistic length stay (LOS)...
Historically, donation after circulatory death (DCD) livers were frequently discarded because of higher mortality and graft loss liver transplantation (LT). However, the demand for LT continues to outstrip supply "acceptable" organs. Additionally, changes in donor pool, organ allocation, clinical management donors recipients, improved protocols might have altered post-DCD-LT outcomes.We studied 5975 recovered DCD using US Scientific Registry Transplant Recipients data from 2005 2017, with a...
Abstract Background Organ transplantation from donors with human immunodeficiency virus (HIV) to recipients HIV (HIV D+/R+) presents risks of donor-derived infections. Understanding clinical, immunologic, and virologic characteristics HIV-positive is critical for safety. Methods We performed a prospective study false-positive (FP) test results within the Policy Equity (HOPE) Act in Action studies D+/R+ (ClinicalTrials.gov NCT02602262, NCT03500315, NCT03734393). compared clinical versus FP...
Kidneys from older (age ≥50 years) donation after cardiac death (DCD50) donors are less likely to be transplanted due inferior posttransplant outcomes. However, candidates who decline a DCD50 offer must wait for an uncertain future offer. To characterize the survival benefit of accepting kidneys, we used 2010-2018 Scientific Registry Transplant Recipients (SRTR) data identify 92 081 adult kidney transplantation were offered that was eventually accepted transplantation. kidneys increased 590...