A5065175925- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- Organ Transplantation Techniques and Outcomes
- SARS-CoV-2 and COVID-19 Research
- Organ Donation and Transplantation
- COVID-19 Clinical Research Studies
- Pregnancy and Medication Impact
- Animal Virus Infections Studies
- Vasculitis and related conditions
- Complement system in diseases
- COVID-19 Impact on Reproduction
- Liver Disease and Transplantation
- COVID-19 and healthcare impacts
- Adolescent and Pediatric Healthcare
- Systemic Lupus Erythematosus Research
- Hepatitis Viruses Studies and Epidemiology
- Organ and Tissue Transplantation Research
- Transplantation: Methods and Outcomes
- Cytomegalovirus and herpesvirus research
- Healthcare Systems and Technology
- Innovations in Medical Education
- Chronic Kidney Disease and Diabetes
- Infectious Encephalopathies and Encephalitis
- Genetic and Kidney Cyst Diseases
- Migration, Health and Trauma
Johns Hopkins University
2019-2024
Johns Hopkins Children's Center
2021-2024
Johns Hopkins Medicine
2020-2024
Children's National
2017-2019
Johns Hopkins Hospital
2018
University of Maryland, College Park
2014
Abstract HLA eplet mismatch load has been suggested as an improvement to antigen determination for organ selection. Given that mismatches are determined based on amino acid sequence difference among alleles, and the frequency of alleles varies between racial groups, we investigated correlation allograft outcomes in 110 pediatric kidney transplant recipients who received their first from a donor same race (SRT) versus different (DRT). Adjusted modified Poisson regression was used assess...
In March 2020, COVID-19 infections began to rise exponentially in the USA, placing substantial burden on healthcare system. As a result, there was rapid change transplant practices and policies, with cessation of most procedures. Our goal understand changes pediatric kidney transplantation (KT) at national level during epidemic.Using SRTR data, we examined waitlist registration, removal or inactivation, deceased donor living (DDKT/LDKT) events start disease transmission USA compared same...
Abstract Background Adolescent solid organ transplant recipients (aSOTRs) who received three doses of the COVID‐19 mRNA vaccine experience high seroconversion rates and antibody persistence for up to 3 months. Long‐term durability beyond this timeframe following SARS‐CoV‐2 remains unknown. We describe responses 6 months third dose (D3) BNT162b2 vaccination among aSOTRs. Methods Participants in a multi‐center, observational cohort were analyzed antibodies spike protein receptor‐binding domain...
Background. HLA-DQ mismatch has been identified as a predictor of de novo donor-specific HLA antibody formation and antibody-mediated rejection. There are insufficient data to guide the incorporation DQ into organ allocation decisions. Methods. We used retrospective longitudinal cohort adult living donor kidney transplant recipients from 11 centers across United States for whom high-resolution class II typing was available. HLA-DQαβ heterodimer allele quantified all donor-recipient pairs,...
Few reports have focused on newer coronavirus disease 2019 (COVID-19) therapies (remdesivir, dexamethasone, and convalescent plasma) in solid organ transplant recipients; concerns had been raised regarding possible adverse impact allograft function or secondary infections.We studied 77 inpatients with COVID-19 during 2 therapeutic eras (Era 1: March-May 2020, 21 patients; Era 2: June-November 56 patients) 52 outpatients.In 1, no patients received remdesivir 4 of (19.4%) plasma, whereas 2,...
Abstract Background Prior to transplantation, effects of advanced CKD contribute malnutrition and impaired growth. After transplant, children are expected thrive, however, in a subset transplant recipients this does not occur. Factors associated with post‐transplant FTT poorly understood. Objective A retrospective cohort study was conducted determine factors association infections hospitalizations. Methods Records 119 transplanted between 2005 2016 were reviewed. defined by ≥2 the following...
Abstract The development of dn DSA anti‐ HLA antibodies has been shown to be a significant risk factor for graft failure. In 2008, we instituted routine protocol standardized monitoring and treatment in pediatric kidney transplant recipients. Of 67 first‐time recipients, 26 (38%) developed after 1.36 ( IQ 1‐2.14) years. Coefficient variance tacrolimus, surrogate marker non‐adherence, was found the single most important development. Overall, there reduction with 19 (76%) children. No...
Stakeholders have expressed concerns regarding decreased deceased donor kidney transplant (DDKT) rates for pediatric candidates under the Kidney Allocation System (KAS). To better understand what might be driving this, we studied Scientific Registry of Transplant Recipients offer data 3642 (age <18 years) kidney-only between December 31, 2012 to 3, 2014 (pre-KAS) and 4, January 6, 2017 (post-KAS). We used negative binomial regression multilevel logistic compare acceptance pre- post-KAS....
Introduction: Childhood nephrotic syndrome is frequently seen in pediatric nephrology practice and often requires patient hospitalization for management. Numerous complications of this disease can be managed an outpatient setting if brought to the attention medical team a timely manner. Outpatient management will reduce healthcare cost improve safety. The goal quality improvement initiative was admissions relapse from 8 <5 at single center 3-month period. Methods: Fish-bone analysis used...
Abstract Despite correction of underlying solid organ failure by transplantation, pediatric transplant recipients still have increased mortality rates compared to the general population, in part due cardiovascular risk. In particular, kidney and non‐kidney with chronic disease significant risk that worsens declining function. Biomarkers associated future such as casual ambulatory hypertension, dyslipidemia, vascular stiffness calcification, left ventricular hypertrophy can be detected...
Abstract In March 2020, COVID-19 infections began to rise exponentially in the United States, placing substantial burden on healthcare system. As a result, there was rapid change transplant practices and policies, with cessation of most procedures. Our goal understand changes pediatric kidney transplantation (KT) at national level during epidemic. Using SRTR data, we examined waitlist registration, removal or inactivation, deceased donor living (DDKT/LDKT) events start disease transmission...
Abstract Background Adult kidney transplant recipients (KTRs) fully vaccinated against COVID‐19 have substantial morbidity and mortality related to SARS‐CoV‐2 infection compared with the general population. However, little is known regarding safety efficacy of vaccination series in pediatric KTRs. Methods A multicenter, retrospective observational study was performed across nine transplantation centers. Eligible KTRs were enrolled data collected pertaining incidence severity, graft outcomes...
The original version of this article unfortunately contained a mistake. In the third paragraph “Discussion,” two references were missing.
Due to changes in duty hour restrictions implemented 2011, the number of formal didactic sessions for pediatrics residents at University Maryland Children's Hospital was reduced by half.The potential negative impact on resident education resulting from restricted hours has been a frequent topic graduate medical literature. This echoed our residency leadership who were concerned that decrease time would adversely affect education, board pass rate and preparedness independent practice.To...