A5060686285- Blood Pressure and Hypertension Studies
- COVID-19 Impact on Reproduction
- Renal Transplantation Outcomes and Treatments
- Birth, Development, and Health
- Polyomavirus and related diseases
- SARS-CoV-2 and COVID-19 Research
- Complement system in diseases
- COVID-19 Clinical Research Studies
- Cardiovascular Syncope and Autonomic Disorders
- Renal Diseases and Glomerulopathies
- Family Caregiving in Mental Illness
- Family and Disability Support Research
- Family and Patient Care in Intensive Care Units
- Organ and Tissue Transplantation Research
- Neuroblastoma Research and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Function and Risk Factors
- Neonatal Health and Biochemistry
- Cardiovascular Effects of Exercise
- Migration, Health and Trauma
- Renal function and acid-base balance
- Dialysis and Renal Disease Management
- Biomedical Research and Pathophysiology
- Parvovirus B19 Infection Studies
- Obesity, Physical Activity, Diet
Lurie Children's Hospital
2012-2025
Northwestern University
2012-2025
Northwestern Memorial Hospital
2012
Immediate-release cysteamine bitartrate (Cystagon; Mylan Pharmaceuticals, Canonsburg, PA) may prevent or delay kidney transplantation and other serious outcomes in patients with cystinosis, but has never been subjected to a prospective clinical trial. Cystagon efficacy requires strict lifelong dosing every 6 hours. Such schedule Cystagon-associated side effects are often cited by as reasons for nonadherence.This open-label, randomized, controlled, crossover trial was powered show that new...
There are limited data on the impact of COVID-19 in children with a kidney transplant (KT). We conducted prospective cohort study through Improving Renal Outcomes Collaborative (IROC) to collect clinical outcome about pediatric KT patients. Twenty-two IROC centers that care for 2732 patients submitted testing and outcomes 281 tested SARS-CoV-2 by PCR. Testing indications included symptoms and/or potential exposures (N = 134, 47.7%) per hospital policy 154, 54.8%). Overall, 24 (8.5%)...
Abstract Background BK viremia after kidney transplantation (KT) poses significant risk for virus‐associated nephropathy and impacts graft survival. Conventional treatment involves reduction of immunosuppression, which in turn may increase rejection. To address this dilemma, use anti‐viral therapy with immunosuppressive properties such as leflunomide is an attractive option. Methods We performed a multi‐center, retrospective chart review to report tolerability effectiveness the eradication...
Hypertension is highly prevalent in pediatric kidney transplant recipients and contributes to cardiovascular death graft loss. Improper blood pressure (BP) measurement limits the ability control hypertension this population. Here, we report multicenter efforts from Improving Renal Outcomes Collaborative (IROC) standardize improve appropriate BP patients.Seventeen centers participated structured quality improvement activities facilitated by IROC, including formal training methods. The primary...
Abstract Renal failure is a rare complication of neuroblastoma or its therapy. To our knowledge, no reports describe treatment children with chemotherapy in the setting renal and maintenance hemodialysis. We report 6‐year‐old child high‐risk who developed requiring long‐term She was subsequently treated 13 cycles intravenous irinotecan 20 mg/m 2 /day oral temozolomide 100 for 5 days before disease progression without any dose adjustments, transfusions, febrile neutropenia diarrhea. This case...
Matossian D, Langman CB, Cohn RA, Ali FN. Obstructive uropathy is associated with polyomavirus viremia in pediatric kidney transplantation. Abstract: BKVN leads to allograft dysfunction following transplantation and preceded by BK viremia. Studies transplant recipients reveal an incidence of viruria ranging from 18% 33%, 6–16%, 2–8%. Specific risk factors have not been clearly elucidated. Retrospective chart review transplants performed January 2005 through December 2009; identify a single...
Abstract Background Adult kidney transplant recipients (KTRs) fully vaccinated against COVID‐19 have substantial morbidity and mortality related to SARS‐CoV‐2 infection compared with the general population. However, little is known regarding safety efficacy of vaccination series in pediatric KTRs. Methods A multicenter, retrospective observational study was performed across nine transplantation centers. Eligible KTRs were enrolled data collected pertaining incidence severity, graft outcomes...
<title>Abstract</title> Background While the increased burden on caregivers of children and adolescents with kidney disease is described, full scope this remains unrecognized unquantified. The Pediatric Renal Caregiver Burden Scale (PR-CBS) a validated tool that evaluates caregiver in population. Objective To assess pediatric failure at tertiary center hospital pre-kidney transplant (KT) dialysis, early post-KT (30 days to 364 days), late (> 1 year). We also aimed demonstrate feasibility...
Romero, Carlos C. Becerril; Kula, Alexander J.; Verghese, Priya S.; Matossian, Debora Author Information