A5086238803- Genetic and Kidney Cyst Diseases
- Adolescent Sexual and Reproductive Health
- Renal and related cancers
- HIV/AIDS Research and Interventions
- Hedgehog Signaling Pathway Studies
- Biomedical Research and Pathophysiology
- Obesity, Physical Activity, Diet
- HIV, Drug Use, Sexual Risk
- Homelessness and Social Issues
- Genetic Syndromes and Imprinting
- Sleep and related disorders
- COVID-19 Impact on Reproduction
- Renal Diseases and Glomerulopathies
- Early Childhood Education and Development
- Child Nutrition and Water Access
- LGBTQ Health, Identity, and Policy
- COVID-19 Clinical Research Studies
- Online and Blended Learning
- Geriatric Care and Nursing Homes
- Innovative Teaching Methods
- Child Nutrition and Feeding Issues
- Entrepreneurship Studies and Influences
- Sphingolipid Metabolism and Signaling
- Innovation and Knowledge Management
- Service-Learning and Community Engagement
California State University, San Bernardino
2003-2024
Cincinnati Children's Hospital Medical Center
2018-2024
Sanofi (United States)
2020-2024
University of Southern California
2024
University of Pittsburgh
2024
The Lundquist Institute
2022
UCLA Medical Center
2022
Ronald Reagan UCLA Medical Center
2022
Lancaster University
2016
Institute of Cell Biology
2012
Significant progress in understanding the molecular mechanisms of polycystic kidney disease (PKD) has been made recent years. Translating this into effective therapeutics will require testing animal models that closely resemble human PKD by multiple parameters. Similar to autosomal dominant PKD, juvenile cystic (jck) mice develop cysts nephron segments, including cortical collecting ducts, distal tubules, and loop Henle. The jck display gender dimorphism progression with more aggressive male...
There are limited data on the impact of COVID-19 in children with a kidney transplant (KT). We conducted prospective cohort study through Improving Renal Outcomes Collaborative (IROC) to collect clinical outcome about pediatric KT patients. Twenty-two IROC centers that care for 2732 patients submitted testing and outcomes 281 tested SARS-CoV-2 by PCR. Testing indications included symptoms and/or potential exposures (N = 134, 47.7%) per hospital policy 154, 54.8%). Overall, 24 (8.5%)...
Autosomal dominant polycystic kidney disease (ADPKD) and other forms of PKD are associated with dysregulated cell cycle proliferation. Although no effective therapy for the treatment is currently available, possible mechanism-based approaches beginning to emerge. A therapeutic intervention targeting aberrant cilia-cell connection using CDK-inhibitor R-roscovitine showed arrest in jck cpk models that not orthologous human ADPKD. To evaluate whether CDK inhibition approach will translate into...
Prenatal fish intake is a key source of omega-3 (ω-3) polyunsaturated fatty acids needed for brain development, yet generally low, and studies addressing associations with autism spectrum disorder (ASD) related traits are lacking. This study aimed to examine prenatal ω-3 supplement use both diagnosis broader autism-related traits. Participants were drawn from 32 cohorts in the Environmental influences on Child Health Outcomes Cohort Consortium. Children born between 1999 2019 part ongoing...
Polycystic kidney diseases (PKDs) comprise a subgroup of ciliopathies characterized by the formation fluid-filled cysts and progression to end-stage renal disease. A mechanistic understanding cystogenesis is crucial for development viable therapeutic options. Here, we identify CDK5, kinase active in post mitotic cells, as new important mediator PKD progression. We show that long-lasting attenuation juvenile cystic kidneys ( jck ) mouse model nephronophthisis pharmacological inhibition CDK5...
A county agency and a social work research class partnered to conduct state-mandated needs assessment of older gay, lesbian, bisexual, transgendered people (GLBT). survey design with purposive sampling GLBT over 60 yielded 38 participants. Findings included that the Internet was viable means reach this population student awareness increased. Areas greatest unmet need were GLBT-oriented/friendly legal advice, events, grief loss counseling, workers, assisted living. Some participants perceived...
This study investigates gender and ethnicity differences in the experience of not using a condom due to partner s influence (unwanted noncondom use). Analysis 247 anonymous questionnaires from students at urban community college campuses revealed that 46.7% had experienced unwanted use since age 16, 37% with their current or most recent partner. Males females reported equal levels use. However, African-American Latino participants higher than Whites. The findings indicate females, males,...
Development of novel therapies for polycystic kidney disease (PKD) requires assays that adequately reflect biology and are adaptable to high-throughput screening. Here we describe an embryonic cystic organ culture model demonstrate a new mutant allele the Pkd1 gene ( tm1Bdgz ) modulates cystogenesis in this model. Cyst formation induced by cAMP is influenced dosage allele: −/− cultures develop larger area compared with +/+ counterparts, while +/− show intermediate phenotype. A similar...
Genetic forms of polycystic kidney diseases (PKDs), including nephronophthisis, are characterized by formation fluid-filled cysts in the kidneys and progression to end-stage renal disease. No therapies currently available treat cystic diseases, making it imperative dissect molecular mechanisms search therapeutic targets. Accumulating evidence suggests a pathogenic role for glucosylceramide (GlcCer) multiple PKD. It is not known, however, whether other structural glycosphingolipids (GSLs) or...
Development of a disease-modifying therapy to treat autosomal dominant polycystic kidney disease (ADPKD) requires well-characterized preclinical models that accurately reflect the pathology and biochemical changes associated with disease. Using Pkd1 conditional knockout mouse, we demonstrate subtly altering timing extent deletion can have significant impact on origin severity cyst formation. postnatal day 1 or 2 results in cysts arising from both cortical medullary regions, whereas days 3–8...
Sleep is necessary for optimal functioning. Little known about the extent to which race and opportunities be active influence sleep in preschool-aged children attending full-day child care. Participants (n = 359) this cross-sectional study attended 30 randomly selected, childcare centers Cincinnati, OH. Data collection occurred from November 2009 January 2011. Hierarchical linear regression generalized estimating equations tested associations between nighttime duration race, outdoor/indoor...
Among new technologies for enhancing classroom-based education are audience response systems (ARS), also known as "clickers." These handheld devices record student responses to instructor questions and send them electronically a receiver that tallies the responses. Summary results then projected, usually graph. Instructors piloted use of clickers in undergraduate social work research practice courses. Instructor experiences with were examined by type course, frequency use, ease perceived...
Abstract Bardet–Biedl syndrome (BBS) is a pleiotropic autosomal recessive ciliopathy affecting multiple organs. The development of potential disease-modifying therapy for BBS will require concurrent targeting multi-systemic manifestations. Here, we show the first time that monosialodihexosylganglioside accumulates in Bbs2−/− cilia, indicating impairment glycosphingolipid (GSL) metabolism BBS. Consequently, tested whether pathology mice can be reversed by underlying ciliary defect via...
Designing an effective research learning experience for undergraduate social work students is challenging. Similarly, although content on elderly adults a natural fit in many parts of the curriculum, doing so course can be difficult challenge. Described this article that has achieved both these goals and also made significant contributions to aging agency and, ultimately, its clients. The authors discuss relevant literature, influential factors course's development, outcome data, elements...
In this paper we evaluate action learning for leaders of social enterprises and charities. Based on ethnographic research including participant observation, facilitator reflective diary notes in-depth, qualitative interviews with participants two sets undertaken over eight months, analysed using Wenger, Trayner, de Laat [2011, "Promoting Assessing Value Creation in Communities Networks: A Conceptual Framework." Open universiteit, Ruud Moor Centrum....