Cindy T. McEvoy
A5064371166- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Infant Development and Preterm Care
- Congenital Diaphragmatic Hernia Studies
- Neuroscience of respiration and sleep
- Birth, Development, and Health
- Air Quality and Health Impacts
- Obesity, Physical Activity, Diet
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Gestational Diabetes Research and Management
- Maternal Mental Health During Pregnancy and Postpartum
- Health disparities and outcomes
- Epigenetics and DNA Methylation
- Pregnancy and preeclampsia studies
- Congenital Heart Disease Studies
- Climate Change and Health Impacts
- Neonatal and fetal brain pathology
- Early Childhood Education and Development
- Smoking Behavior and Cessation
- Child and Adolescent Psychosocial and Emotional Development
- Breastfeeding Practices and Influences
- Prenatal Substance Exposure Effects
- Obesity and Health Practices
- Tracheal and airway disorders
Oregon Health & Science University
2016-2025
RTI International
2024
Northern Arizona University
2024
Johns Hopkins University
2023-2024
Pennsylvania State University
2024
Doernbecher Children's Hospital
2020-2024
Cohort (United Kingdom)
2024
Oregon Clinic
2023
Indiana University – Purdue University Indianapolis
2019-2023
Oregon National Primate Research Center
2014-2023
Maternal smoking during pregnancy adversely affects offspring lung development, with lifelong decreases in pulmonary function and increased asthma risk. In a primate model, vitamin C blocked some of the in-utero effects nicotine on development function.To determine if newborns pregnant smokers randomized to receive daily would have improved results tests (PFTs) decreased wheezing compared those placebo.Randomized, double-blind trial conducted 3 sites Pacific Northwest between March 2007...
Abstract The Environmental Influences on Child Health Outcomes (ECHO)-Wide Cohort Study (EWC), a collaborative research design comprising 69 cohorts in 31 consortia, was funded by the National Institutes of (NIH) 2016 to improve children’s health United States. EWC harmonizes extant data and collects new using standardized protocol, ECHO-Wide Data Collection Protocol (EWCP). EWCP visits occur at least once per life stage, but frequency timing vary across cohorts. As March 4, 2022,...
Importance The COVID-19 pandemic led to widespread lockdowns and school closures that may have affected screen time among children. Although restrictions were strongest early in the pandemic, it is unclear how changed as progressed. Objective To evaluate change children’s from before during July 2019 through August 2021. Design, Setting, Participants This a longitudinal cohort study with repeated measures of collected 2 periods. Children aged 4 12 years their parent enrolled 3 pediatric...
Most premature human infants are born in the moderate to late preterm (MLP) range, ≥30 <37 weeks gestation and demonstrate increased incidence of wheeze respiratory illness as they age. Animal models suggest that mechanical lung distention stimulates growth alveolar development. To determine if nasal continuous positive airway pressure (nCPAP) influences MLP infant development, we developed a rhesus monkey model prematurity, randomized 9 days nCPAP or sham nCPAP. Timed-pregnant fetuses were...
Extended continuous positive airway pressure (eCPAP) in the neonatal intensive care unit (NICU) for stable preterm infants increases lung volumes. Its effect on growth after discharge is unknown. To assess whether 2-weeks of eCPAP associated with increased alveolar volume (VA) at 6-months corrected age. Randomized controlled trial conducted Oregon Health & Science University. Outpatient assessors unaware treatment assignment. 100 randomized to versus CPAP discontinuation (dCPAP) room air....
Use of e-cigarettes, especially among the young, is increasing at near-exponential rates. This coupled with a perception that e-cigarettes are safe and unlimited advertising geared toward vulnerable populations, groups most likely to smoke or vape during pregnancy. There now wide appreciation dangers maternal smoking pregnancy lifelong consequences this has on offspring lung function, including increased risk childhood wheezing subsequent asthma. Recent evidence strongly supports much effect...
Observational studies suggest that minimal gestational weight gain (GWG) may optimize pregnancy outcomes for obese women. This trial tested the efficacy of a group-based management intervention limiting GWG among women.One hundred and fourteen women (BMI [mean ± SD] 36.7 4.9 kg/m(2) ) were randomized between 7 21 weeks' (14.9 2.6) gestation to (n = 56) or usual care control conditions 58). The included individualized calorie goals, advice maintain within 3% randomization follow Dietary...
Infants whose mothers smoked during pregnancy demonstrate lifelong decreases in pulmonary function. DNA methylation changes associated with maternal smoking have been described placenta and cord blood at delivery, fetal lung, buccal epithelium childhood. We demonstrated a randomized clinical trial ( ClinicalTrials.gov identifier, NCT00632476) that vitamin C supplementation to pregnant smokers can lessen the impact of on offspring function decrease incidence wheeze 1 year age.To determine...
Experts hypothesized increased weight gain in children associated with the coronavirus disease 2019 (COVID-19) pandemic. Our objective was to evaluate whether rate of change child body mass index (BMI) during COVID-19 pandemic compared prepandemic years. The study population 1996 ages 2 19 years at least 1 BMI measure before and drawn from 38 pediatric cohorts across United States participating Environmental Influences on Child Health Outcomes-wide cohort study. We modeled using linear mixed...
Importance Preeclampsia, gestational hypertension, and diabetes, the most common pregnancy complications, are associated with substantial morbidity mortality in mothers children. Little is known about biological processes that link occurrence of these complications adverse child outcomes; altered aging growing fetus up to birth one molecular pathway increasing interest. Objective To evaluate whether exposure each 3 (gestational preeclampsia) accelerated or decelerated age children at birth....
Importance The prevalence of cannabis use in pregnancy is rising and associated with adverse perinatal outcomes. In parallel, combined prenatal nicotine also increasing, but little known about the impact both substances on offspring outcomes compared each substance alone. Objective To assess exposure alone during pregnancy. Design, Setting, Participants This retrospective population-based cohort study included linked hospital discharge data (obtained from California Department Health Care...
Widespread exposure to organophosphate ester (OPE) flame retardants with potential reproductive toxicity raises concern regarding the impacts of gestational on birth outcomes. Previous studies prenatal OPE and outcomes had limited sample sizes, inconclusive results.
Objective. To determine the changes in pulmonary mechanics before and during early dexamethasone therapy, to evaluate effect of on duration mechanical ventilation very low birth weight (VLBW) ventilator-dependent infants at risk for chronic lung disease (CLD). Methods. A prospective randomized trial was conducted. Forty-three patients (birth 600 1500 g, gestational age 24 32 weeks) who failed be weaned from respirator 7 14 days were enrolled; 23 received a 7-day course (0.5 mg/kg/day...
Earlier pubertal onset may be associated with an increased risk of chronic diseases. However, the extent to which growth in first 5 years life-an important developmental life stage that lays foundation for later health outcomes-is remains understudied.
Abstract Background Epigenetic clocks are promising tools for assessing biological age. We assessed the accuracy of pediatric epigenetic in gestational and chronological age determination. Results Our study used data from seven tissue types on three DNA methylation profiling microarrays found that Knight Bohlin performed similarly blood cells, while Lee clock was superior placental samples. The pediatric-buccal-epigenetic best buccal samples, Horvath is recommended children's cell NeoAge...
Objective This analysis was focused on 1‐year maternal and infant follow‐up of a randomized trial that tested weight management intervention conducted during pregnancy. Methods One hundred fourteen women with obesity (mean BMI 36.7 kg/m 2 ) were randomly assigned at mean 15 weeks gestation to or usual care control condition. The ended delivery resulted in less gestational gain lower proportion large‐for‐gestational‐age newborns among compared participants. primary outcome 12 months...