A5002605572- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Congenital Diaphragmatic Hernia Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inhalation and Respiratory Drug Delivery
- Neuroscience of respiration and sleep
- Cystic Fibrosis Research Advances
- Birth, Development, and Health
- Respiratory and Cough-Related Research
- Infant Development and Preterm Care
- Allergic Rhinitis and Sensitization
- Pediatric health and respiratory diseases
- Tracheal and airway disorders
- Dermatology and Skin Diseases
- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- Respiratory viral infections research
- Pregnancy and preeclampsia studies
- Pulmonary Hypertension Research and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Advanced Sensor and Energy Harvesting Materials
- Climate Change and Health Impacts
- High Altitude and Hypoxia
- Child and Adolescent Health
Hofstra University
2025
Cohen Children's Medical Center
2025
Northwell Health
2025
Indiana University – Purdue University Indianapolis
2016-2025
Indiana University School of Medicine
2016-2025
Indiana University
1993-2024
Cohort (United Kingdom)
2024
University of South Dakota
2024
Avera Health
2024
Oregon Health & Science University
2019-2023
T helper 9 (Th9) cells are specialized for the production of IL-9, promote allergic inflammation in mice, and associated with disease humans. It has not been determined whether Th9 express a characteristic transcriptional signature. In this study, we performed microarray analysis to identify genes enriched compared other Th subsets. This defined regulatory network required expression subset Th9-enriched genes. The activator protein 1 (AP1) family transcription factor BATF (B cell, activating...
Importance The COVID-19 pandemic led to widespread lockdowns and school closures that may have affected screen time among children. Although restrictions were strongest early in the pandemic, it is unclear how changed as progressed. Objective To evaluate change children’s from before during July 2019 through August 2021. Design, Setting, Participants This a longitudinal cohort study with repeated measures of collected 2 periods. Children aged 4 12 years their parent enrolled 3 pediatric...
Most premature human infants are born in the moderate to late preterm (MLP) range, ≥30 <37 weeks gestation and demonstrate increased incidence of wheeze respiratory illness as they age. Animal models suggest that mechanical lung distention stimulates growth alveolar development. To determine if nasal continuous positive airway pressure (nCPAP) influences MLP infant development, we developed a rhesus monkey model prematurity, randomized 9 days nCPAP or sham nCPAP. Timed-pregnant fetuses were...
Extended continuous positive airway pressure (eCPAP) in the neonatal intensive care unit (NICU) for stable preterm infants increases lung volumes. Its effect on growth after discharge is unknown. To assess whether 2-weeks of eCPAP associated with increased alveolar volume (VA) at 6-months corrected age. Randomized controlled trial conducted Oregon Health & Science University. Outpatient assessors unaware treatment assignment. 100 randomized to versus CPAP discontinuation (dCPAP) room air....
The purpose of this study was to evaluate spirometric lung function in normal children ages 3 6 yr. Spirometric measurements were obtained at nursery and daycare centers by experienced pediatric pulmonary technicians. Of 307 recruited, 259 fulfilled our criteria as normal. these, 82.6% (214) able perform technically acceptable reproducible maneuvers during a testing session limited 15 min. regression model with log-transformed parameters height had the best correlations. After accounting for...
Forced expiratory flows (FEF) can be measured in infants from lung volumes initiated near total capacity. In order to establish reference values and evaluate growth, we obtained measurements 155 healthy subjects between 3 149 wk of age. vital capacity (FVC) was highly correlated with body length; however, after accounting for length, age also significant. When were divided at the median (40 wk) younger compared older had a significantly larger slope length (3.7 versus 2.8; p = 0.002). The...
The clinical pathology describing infants with chronic lung disease of infancy (CLDI) has been limited and obtained primarily from severe disease, who either died or required biopsy. As tissue clinically stable outpatients is not available, physiological measurements offer the potential to increase our understanding pulmonary pathophysiology this disease.
Importance Physical and social neighborhood attributes may have implications for children’s growth development patterns. The extent to which these are associated with body mass index (BMI) trajectories obesity risk from childhood adolescence remains understudied. Objective To examine associations of neighborhood-level measures opportunity vulnerability BMI birth adolescence. Design, Setting, Participants This cohort study used data 54 cohorts (20 677 children) participating in the...
Despite IL-9 functioning as a pleiotropic cytokine in mucosal environments, the IL-9–responsive cell repertoire is still not well defined. Here, we found that mediates proallergic activities lungs by targeting lung macrophages. inhibits alveolar macrophage expansion and promotes recruitment of monocytes develop into CD11c + − interstitial populations. Interstitial macrophages were required for IL-9–dependent allergic responses. Mechanistically, affected function inducing Arg1 activity....
Importance Preeclampsia, gestational hypertension, and diabetes, the most common pregnancy complications, are associated with substantial morbidity mortality in mothers children. Little is known about biological processes that link occurrence of these complications adverse child outcomes; altered aging growing fetus up to birth one molecular pathway increasing interest. Objective To evaluate whether exposure each 3 (gestational preeclampsia) accelerated or decelerated age children at birth....
Because of the wide utilization rodents as animal models in respiratory research and limited data on measurements input impedance (Zrs) small animals, we measured Zrs between 0.25 9.125 Hz at different levels (0–7 hPa) positive end-expiratory pressure (PEEP) mice, rats, guinea pigs, rabbits using a computer-controlled small-animal ventilator (Schuessler TF Bates JHT, IEEE Trans Biomed Eng 42: 860–866, 1995). was fitted with model, including Newtonian resistance (R) inertance series...
Shen, X., M. F. Wu, R. S. Tepper, and J. Gunst. Mechanisms for the mechanical response of airway smooth muscle to length oscillation. Appl. Physiol. 83(3): 731–738, 1997.—Airway tone in vitro is profoundly affected by oscillations length, suggesting that effects lung volume changes on result from direct stretch muscle. We analyzed effect oscillation active force length-force hysteresis canine tracheal at different rates amplitudes during contraction with acetylcholine. During shortening...
Abstract The purpose of this study was to examine lung function and bronchodilator responsiveness in infants with a history prematurity bronchopulmonary dysplasia (BPD), using the raised volume rapid thoracoabdominal compression technique as well whole‐body plethysmography. Spirometric measurements were obtained 28 BPD, defined preterm birth O 2 requirement at 36 weeks postmenstrual age (gestational birth, 26.4 ± 2.1 weeks, mean SD; birthweight, 898 353 g; study, 68.0 35.6 weeks). Fractional...
Because the presence of bronchial smooth muscle reactivity in infants remains controversial, airway was assessed 10 normal, asymptomatic male less than 15 mo age by measuring changes that occurred maximal expiratory flows at functional residual capacity (VmaxFRC) during a methacholine challenge test. Sleeping inhaled doubling concentrations 2 min tidal breathing, starting with concentration 0.075 mg/ml, and stopped when VmaxFRC decreased least 40%. The threshold required to produce decrease...
It remains unclear whether premature birth, in the absence of neonatal respiratory disease, results abnormal growth and development lung. We previously reported that a group healthy infants born at 32-34 weeks' gestation without complications had decreased forced expiratory flows normal vital capacities 2 months age.Our current study evaluated these prematurely exhibited improvement or "catch-up" their lung function during second year life.Longitudinal measurements by raised volume rapid...
Seventeen ventilator-dependent premature infants with bronchopulmonary dysplasia (BPD) were enrolled in a double-blind, placebo-controlled study to determine the effect of 3 days intravenously administered dexamethasone (0.5 mg/kg/day) on pulmonary function, inflammation, and requirement for respiratory support (FiO2, ventilator peak pressure [PP], rate [RR]). Assessment function included measurement FVC, flow at 25% vital capacity (25), static compliance system (Crs), whereas inflammation...