A5014460750- interferon and immune responses
- Peptidase Inhibition and Analysis
- Influenza Virus Research Studies
- RNA modifications and cancer
- MicroRNA in disease regulation
- COVID-19 Clinical Research Studies
- Immune Response and Inflammation
- Inflammasome and immune disorders
- Aquaculture disease management and microbiota
- Extracellular vesicles in disease
- Enzyme Production and Characterization
- Chromosomal and Genetic Variations
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Effects of Radiation Exposure
- Cancer-related Molecular Pathways
- Inhalation and Respiratory Drug Delivery
- Genomics and Chromatin Dynamics
- Cancer, Stress, Anesthesia, and Immune Response
- Invertebrate Immune Response Mechanisms
- Protease and Inhibitor Mechanisms
- Virus-based gene therapy research
- DNA Repair Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Nanyang Normal University
2021-2025
University of North Carolina at Chapel Hill
2022-2025
UNC Lineberger Comprehensive Cancer Center
2024
Second Affiliated Hospital of Zhejiang University
2023
Indiana University
2018-2023
Guizhou University
2023
Cell Technology (China)
2023
Shandong Provincial Hospital
2022
Shandong First Medical University
2022
Indiana University – Purdue University Indianapolis
2020-2022
Differing from the mouse Foxp3 gene that encodes only one protein product, human FOXP3 two major isoforms through alternative splicing—a longer isoform (FOXP3 FL) containing all coding exons and a shorter lacking amino acids encoded by exon 2 ΔE2). The are naturally expressed in humans, yet their differences controlling regulatory T cell phenotype functionality remain unclear. In this study, we show patients expressing fail to maintain self-tolerance develop immunodeficiency,...
Despite IL-9 functioning as a pleiotropic cytokine in mucosal environments, the IL-9–responsive cell repertoire is still not well defined. Here, we found that mediates proallergic activities lungs by targeting lung macrophages. inhibits alveolar macrophage expansion and promotes recruitment of monocytes develop into CD11c + − interstitial populations. Interstitial macrophages were required for IL-9–dependent allergic responses. Mechanistically, affected function inducing Arg1 activity....
Prolonging the reproductive lifespan is beneficial for preserving physical and psychological health of women. The transplantation mesenchymal stem cell (MSC)‑derived exosomes (MSC‑Exos) has been reported to be a promising regenerative therapeutic strategy restoring function aging ovaries. present study thus evaluated efficacy derived from human umbilical cord‑MSCs (hUCMSC‑Exos) in mouse model natural ovarian (NOA), further investigated role exosomal microRNAs (miRNAs/miRs) mechanisms this...
The p53 tumor suppressor controls cell growth, metabolism, and death by regulating the transcription of various target genes. target-specific transcriptional activity is highly regulated. Here we demonstrate that acetylation at Lys-120 up-regulates its toward Apaf-1, a core component in mitochondrial apoptotic pathway, thus sensitizes caspase activation apoptosis. We found histone deacetylase (HDAC) inhibitors, including butyrate, augment Apaf-1 expression inhibiting HDAC1. In p53-null...
Abstract Extracellular vesicles (EVs) derived from human umbilical cord mesenchymal stem cells (hUCMSCs) have emerged as promising candidates for cell-free therapy in various diseases, including chronic cutaneous wounds. However, the lack of standardized protocols EVs’ preparation and identification poses a significant challenge to their clinical application. Thus, objective was develop safe efficient method large-scale production hUCMSC-derived EVs while establishing comprehensive protocol...
RIG-I-like (where RIG-I is retinoic acid inducible gene I) receptor LGP2 laboratory of genetics and physiology) an important intracellular that recognizes viral RNAs in innate immunity, but its origin evolution remains unknown. Here we clearly demonstrate the presence a receptor, BjLGP2, basal chordate amphioxus. It predominantly expressed hepatic caecum hindgut, upregulated following challenge with poly(I:C). BjLGP2 distributed cytoplasm both grouper spleen flounder gill (FG) cells,...
Abstract Aspergillus niger has the ability to produce a large variety of proteases, which are particular importance for protein digestion, intracellular turnover, cell signaling, flavour development, extracellular matrix remodeling and microbial defense. However, A. degradome (the full repertoire peptidases encoded by genome) available is not accurate comprehensive. Herein, we have utilized annotations proteases in AspGD, JGI, version 12.2 MEROPS database compile an index at least 232...
Thrombocytopenia, hemorrhage, anemia, and infection are life-threatening issues following accidental or intentional radiation exposure. Since few therapeutics available, safe efficacious small molecules to mitigate radiation-induced injury need be developed. Our previous study showed the synthetic TLR2/TLR6 ligand fibroblast stimulating lipopeptide (FSL-1) prolonged survival provided MyD88-dependent mitigation of hematopoietic acute syndrome (H-ARS) in mice. Although mice humans differ TLR...
Histone acetylation is a key histone post-translational modification that shapes chromatin structure, dynamics, and function. Bromodomain (BRD) proteins, the readers of acetyl-lysines, are located in center acetylation-signaling network. How they regulate DNA repair genome stability remains poorly understood. Here, conserved function yeast Factor 1 (Bdf1) its human counterpart TAF1 reported promoting double-stranded break by homologous recombination (HR). Depletion either BDF1 or TAF1,...
Mitogen-activated protein kinases (MAPKs) and heat shock proteins (HSPs) are ubiquitous that functional mediators in both normal stressed states of the cell. In this study, we performed stress (37 °C) experiments on turbot kidney (TK) cells. Heat expression patterns HSP90, as well phosphorylation levels extracellular-regulated signal (ERKs) transcription factor HSF1 c-Fos, were examined. The results show activates ERK1/2 HSF1, induces HSP90 gene TK Inhibition ERK activation attenuates...
OPINION article Front. Immunol., 12 September 2022Sec. Nutritional Immunology Volume 13 - 2022 | https://doi.org/10.3389/fimmu.2022.967215
Xaa-Pro dipeptidase (XPD, EC 3.4.13.9; also known as prolidase) catalyzes the hydrolysis of iminopeptide bond in trans-Xaa-Pro dipeptides (Xaa represents any amino acid except proline), which makes it find wide applications food, medical and environmental protection fields. In present study, a novel from Aspergillus phoenicis ATCC 14332 (ApXPD) was heterologously expressed biochemically characterized. Reclassification based on phylogenetic analysis version 12.5 MEROPS database showed that...
Mink enteritis virus (MEV), as a parvovirus, is among the smallest of animal DNA viruses. The limited genome leads to multifunctional sequences and complex gene expression regulation. Here, we show that viral capsid protein 2 (VP2) MEV requires its 5' untranslated regions (5' UTR) which promote VP2 at both transcriptional translational levels. was inhibited in several common eukaryotic vectors. Our data showed UTR enhanced transcription but not increased stability or promotes...