A5103055413- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Liver Diseases and Immunity
- Magnesium Oxide Properties and Applications
- Inflammatory Bowel Disease
- Mesenchymal stem cell research
- Cytomegalovirus and herpesvirus research
- MicroRNA in disease regulation
- Microscopic Colitis
- Gut microbiota and health
- Cytokine Signaling Pathways and Interactions
- Layered Double Hydroxides Synthesis and Applications
- Digestive system and related health
- Organ Transplantation Techniques and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Advanced Neural Network Applications
- Multiferroics and related materials
- Acupuncture Treatment Research Studies
- Fungal Biology and Applications
- Enhanced Recovery After Surgery
- Lipid metabolism and disorders
- Materials Engineering and Processing
- Cystic Fibrosis Research Advances
- Phosphorus and nutrient management
Second Hospital of Hebei Medical University
2013-2024
Liaoning Planning and Design Institute of Post and Telecommunication
2022-2024
Hebei Medical University
2012-2024
Zhejiang University
2024
Anhui University
2022
Fudan University
2021
Zhongshan Hospital
2021
Abstract Background Inflammatory bowel disease (IBD) is a global health problem in which gut microbiota dysbiosis plays pivotal pathogenic role. Mesenchymal stem cells (MSCs) therapy has emerged as prospective novel tool for managing IBD, and can also regulate the composition of microbiota. However, functional significance MSCs-induced changes microbiome poorly understood. Methods Here, we investigated first time role mediating protective effect human umbilical cord MSCs (HUMSCs) on...
To investigate the hepatic differentiation potential of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) and to evaluate their therapeutic effect on liver fibrosis/cirrhosis.A CCl4-induced fibrotic/cirrhotic rat model was used assess hUC-MSCs. Histopathology assessed by hematoxylin eosin (H&E), Masson trichrome Sirius red staining. The biochemical profile measured using a Beckman Coulter analyzer. Expression analysis performed immunofluorescent staining, immunohistochemistry,...
Retarders are important factors controlling the hydration and properties of magnesium potassium phosphate cements (MKPCs). Boric acid borax most commonly used retarders for MKPC which could control setting time in a wide range upon changing their content. However, with increase content, early strength can be reduced, boron compounds now included EU candidate list substances very high concern authorization, due to reproductive toxicity. Exploring alternative set is, thus, significance. This...
Background. The sympathetic nervous system (SNS) is responsible for hepatic stellate cells (HSCs) activation and the accumulation of collagen that occurs in fibrogenesis. Carvedilol has been widely used complication cirrhosis clinic. Furthermore, it powerful antioxidant properties. We assessed potential antifibrotic effects carvedilol underlying mechanisms may further enhance its clinical benefits. Methods. Using a bile duct ligation rat model fibrosis, we studied on deposition, oxidative...
Macrophages are the master regulator of dynamic fibrogenesis–fibrosis resolution paradigm. TNF-like ligand 1 aberrance (TL1A) was found to be able induce intestinal inflammation and fibrosis. Furthermore, significantly increased TL1A had been detected in liver tissues mononuclear cells patients with primary biliary cirrhosis (PBC). This study investigate effect myeloid constitutive expression on fibrogenesis. We that expressions macrophages were mice fibrosis induced by injection carbon...
To evaluate the change in phosphatase and tensin homology deleted on chromosome ten (PTEN) expression liver fibrogenesis, particularly reversal of fibrogenic tissues, to investigate relation with proliferation apoptosis hepatic stellate cells (HSCs) vivo, a rat model fibrosis was established by hypodermic injection carbon tetrachloride (CCl4) mixed olive oil at concentration 40% for 5 weeks (2 ml/kg, twice week). Reversal achieved normal feedings 4 after CCl4 weeks. The PTEN measured...
Vehicle re-identification (Re-ID) task has far-reaching practical application value and research significance in busy traffic monitoring scenes. Most existing works are based on the single RGB modality or RGB-IR (Infrared) cross-modality. Still, it is difficult to be widely applied multi-scene real life because of inadequacy a at limited daytime. Recently, multi-spectral Re-ID been proposed simultaneously use IR spectral data build cell that can complement each other deal with this...
Abstract Magnesium potassium phosphate hexahydrate (MgKPO 4 ·6H 2 O) was used as solidification matrix to immobilize some radioactive element and heavy metal ions, the stability of MgKPO O under different conditions had become focus. This work gives new insights on synthesized in temperatures pH values solutions. The solid phase transformed from characterized by X‐ray diffractometer (XRD), thermal gravity analysis (TG/DSC), Fourier‐transform infrared spectrum (FTIR) scanning electron...
Background: The progression of liver disorders is frequently associated with inflammatory bowel disease through the gut-liver axis. However, no direct evidence showed mechanisms ulcerative colitis (UC) in development fibrosis per se . Thus, this study aimed to evaluate effects UC on and its potential mechanism experimental model. Methods: Male C57BL/6 mice were allocated into five groups ( n = 10 group) receive either drinking water (control), 2% dextran sulfate sodium (DSS), olive oil,...
Nonalcoholic steatohepatitis (NASH) is a progressive, chronic liver disease worldwide which imposes large economic burden on society. M1/M2 macrophage balance destruction and recruitment of mononuclear immune cells to the play critical roles in NASH. Several studies have shown that expression TNF-like ligand 1 aberrance (TL1A) increased macrophages associated with many inflammatory diseases, for example, bowel disease, primary biliary cholangitis, fibrosis. One recent research showed weight,...
CCN6 is a secretory protein with functions of maintaining mitochondrial homeostasis and anti-oxidative stress; yet, whether it involved in the pathogenesis non-alcoholic steatohepatitis (NASH) still obscure. We investigated role mechanism development NASH.Human liver tissue samples were collected to detect expression profile CCN6. High-fat-high-cholesterol (HFHC) methionine choline-deficient (MCD) diet applied mice establish NASH animal models. Liver-specific overexpression was induced by...
Objectives To investigate the effect of tumor necrosis factor ligand-related molecule 1A (TL1A) on intestinal mucosal barrier in mice with chronic colitis. Methods Male TL1A-overexpressing transgenic and male C57BL/6 wild-type were used to establish a dextran sodium sulfate (DSS)-induced colitis model. The expression occludin claudin-1 was observed. Bacterial distribution mucosa Th9/interleukin (IL)-9 detected. In vitro co-culture systems naive CD4 + T cells Caco-2 established TL1A added....
<title>Abstract</title> Intestinal fibrosis is a serious complication of inflammatory bowel disease (IBD). Proteinase-activated receptor (PAR) 1 highly conserved G protein-coupled that relevant to IBD. We investigated the expression PAR1 in progression intestinal human tissues and mice with chronic enteritis. acquired biopsy samples from 6 patients stenotic UC, CD, without IBD (control individuals). Biopsy were analyzed through histology test for immunohistochemistry RT‒qPCR measure levels...
Magnesium phosphate cement (MPC), as a rapid-hardening and early-strengthening cementitious material, is commonly used for repairing concrete defects. To enhance the repair efficiency of MPC its mortar, mortar paste with addition 40% fly ash 20% slag were studied designed to evaluate performance in different types defects such cracks surface spalling. The test results flexural bond strength, splitting tensile pull-off fracture toughness indicate that neat exhibits highest cut surfaces...
Due to the limited active surface area of perovskite oxides, improving their electrocatalytic performance faces many challenges. To solve this problem, defect engineering and hollow nanostructures have become effective strategies....