A5071298692- Hematopoietic Stem Cell Transplantation
- Monoclonal and Polyclonal Antibodies Research
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- thermodynamics and calorimetric analyses
- Immunotherapy and Immune Responses
- Effects of Radiation Exposure
- Reliability and Agreement in Measurement
- Hemodynamic Monitoring and Therapy
- T-cell and B-cell Immunology
- Analytical Methods in Pharmaceuticals
- Advanced Biosensing Techniques and Applications
Wake Forest University
2014-2023
Pfizer (United States)
2017-2018
Electrical impedance aggregometry (EIA) has gained popularity in clinical and research applications. Nonhuman primates are used to study disease drug-related mechanisms that affect hemostasis, therefore establishing normal EIA parameters necessary. The anticoagulants sodium heparin, hirudin citrate three agonists, ADP, ASPI, collagen were evaluated. Whole blood from 12 adult male rhesus macaques was collected evaluate anticoagulants, using agonists (ADP, ASPI collagen), on the Multiplate®...
Thrombocytopenia, hemorrhage, anemia, and infection are life-threatening issues following accidental or intentional radiation exposure. Since few therapeutics available, safe efficacious small molecules to mitigate radiation-induced injury need be developed. Our previous study showed the synthetic TLR2/TLR6 ligand fibroblast stimulating lipopeptide (FSL-1) prolonged survival provided MyD88-dependent mitigation of hematopoietic acute syndrome (H-ARS) in mice. Although mice humans differ TLR...