A5100405026- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- interferon and immune responses
- Inflammasome and immune disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- HIV Research and Treatment
- Viral Infections and Vectors
- Phagocytosis and Immune Regulation
- Monoclonal and Polyclonal Antibodies Research
- Biochemical Analysis and Sensing Techniques
- Inflammation biomarkers and pathways
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cell Adhesion Molecules Research
- Nanoplatforms for cancer theranostics
- Adipokines, Inflammation, and Metabolic Diseases
- Viral Infections and Outbreaks Research
- Tuberculosis Research and Epidemiology
- Kawasaki Disease and Coronary Complications
- Autophagy in Disease and Therapy
- RNA Research and Splicing
- IL-33, ST2, and ILC Pathways
Third Xiangya Hospital
2022-2025
Central South University
2022-2025
Wuhan Institute of Virology
2018-2025
Wuhan University
2018-2025
Guizhou University
2025
Zhejiang University
2024
Stanford University
2024
Guangxi Medical University
2023
Harbin Medical University
2023
Fourth Affiliated Hospital of Harbin Medical University
2023
•The periportal zone of the hepatic lobules plays an essential role in emergence endotoxemia-associated liver injury.•The reprogramming hepatocytes into a proinflammatory subpopulation is key endotoxemia-induced immune response.•Proinflammatory recruit circulating monocytes to form RMs via CCL2-CCR2 during endotoxemia.•RMs induce inhibitory ligand expression by hepatocytes, leading T lymphocyte suppression partly PD-1/PD-L1 interactions. Background & AimsThe crucial roles regulation defense...
CD47 performs a vital function in cancer therapy by binding to different SIRPα, thrombospondin 1, and integrin. However, its role tumor immunity correlation with prognosis among many types remain unknown. The raw mRNA expression data of patients was downloaded from TCGA GTEx datasets. protein detected using microarray. Kaplan Meier analysis forest plot were performed compare the effects high low on overall survival cancers. In addition, correlations between immune cell infiltration, stromal...
γδ T cells are essential for immune defense and modulating physiological processes. While they have the potential to recognize large numbers of antigens through somatic gene rearrangement, which trigger most cell response remain unidentified, role antigen recognition in function is contentious. Here, we show that some receptors (TCRs) exhibit polyspecificity, recognizing multiple ligands diverse molecular nature. These include haptens, metabolites, neurotransmitters, posttranslational...
Abstract Hantaan virus (HTNV) infection causes severe hemorrhagic fever with renal syndrome (HFRS) in humans and the infectious process can be regulated by autophagy. The phosphatase tensin homolog (PTEN) protein has antiviral effects plays a critical role autophagy pathway. However, relationship between PTEN HTNV is not clear whether PTEN‐regulated involves replication unknown. Here, we identified that inhibits expression vitro vivo. glycoprotein Gc promotes ubiquitination degradation...
Abstract Regulatory T (T reg ) cells are a distinct T-cell lineage characterized by sustained Foxp3 expression and potent suppressor function, but the upstream dominant factors that preserve lineage-specific features mostly unknown. Here, we show Lkb1 maintains cell identity stabilizing enforcing function. Upon receptor (TCR) stimulation protein is upregulated in not conventional cells. Mice with cell-specific deletion of develop fatal early-onset autoimmune disease, no most stabilizes...
Neutrophil extracellular traps (NETs) have been categorized as a form of inflammatory cell death mode neutrophils (NETosis) involved in natural immunity and the regulation adaptive immunity. More more studies revealed ability NETs to reshape tumor immune microenvironment (TIME) by limiting antitumor effector cells, which may impair efficacy immunotherapy. To explore whether NETs-related genes make vital impacts on Colon carcinoma (COAD), we carried out systematic analysis showed several...
Abstract Vascular calcification is a highly regulated process in cardiovascular disease (CVD) and strongly correlated with morbidity mortality, especially the adverse stage of vascular remodeling after coronary artery bypass graft surgery (CABG). However, pathogenesis calcification, particularly role endothelial‐smooth muscle cell interaction, still unclear. To test how ECs interact SMCs grafts, single‐cell analysis wild‐type mice first performed using an arterial isograft mouse model found...
Retroviruses selectively package two copies of their unspliced genomes by what appears to be a dimerization-dependent RNA packaging mechanism. Dimerization human immunodeficiency virus Type-1 (HIV-1) is initiated "kissing" interactions between GC-rich palindromic loop residues conserved hairpin (DIS), and indirectly promoted long-range base pairing overlapping the gag start codon (AUG) an upstream Unique 5′ element (U5). The DIS U5:AUG structures are phylogenetically among divergent...
PUM1 is an RNA binding protein shown to regulate the stability and function of mRNAs bearing a specific sequence. We report following: (i) A key that repressor innate immunity genes by repressing expression LGP2. Thus, between 12 48 hours after transfection human cells with siPUM1 there was initial (phase 1) upsurge transcripts encoding LGP2, CXCL10, IL6, PKR. This followed 24 later 2) significant accumulation RIG-I, SP100, MDA5, IFIT1, PML, STING, IFNβ. The were not activated encoded HDAC4...
Abstract The expression, biological functions and underlying molecular mechanisms of endothelial cell-specific molecule 1 (ESM1) in human cervical cancer remain unclear. Bioinformatics analysis revealed that ESM1 expression was significantly elevated tissues, correlating with patients’ poor prognosis. Moreover, mRNA protein upregulation detected local tissues various cells. In established primary cells, shRNA or CRISPR/Cas9-induced KO hindered cell proliferation, cycle progression, vitro...
RIPK1 is crucial in the inflammatory response. The process of vascular graft remodeling also involved endothelial inflammation, which can influence behavior smooth muscle cells. However, role arterial bypass grafts remains unknown. Here, we established an isograft mouse model wild-type and conditional knockout mice. Progressive neointima formation occurred artery, showing SMC accumulation together with adhesion molecule cytokine expression. Endothelial exacerbated stenosis by increasing...
There has been a great deal of evidence indicating that cytokines participate in meningeal inflammation. Different cytokine profiles may be presented central nervous system (CNS) infection due to different pathogens. We have attempted investigate cerebrospinal fluid (CSF) patients with CNS infection. Forty-three including tuberculous meningitis, purulent meningitis and cryptococcal were enrolled 11 normal CSF as control group. The concentrations Th1-, Th2- Th17-type detected using multiplex...
Background and Objective: As bronchopulmonary dysplasia (BPD) can lead to considerable mortality morbidity, this disease is the focus of attention in neonatology. Vitamin D (VD) , which has anti-inflammatory properties promotes lung growth, may have a therapeutic effect on BPD. Neutrophil extracellular traps (NETs) overexpression were demonstrated be involved pathogenesis BPD our previous study. This study aimed elucidate VD role NETs process. Methods: Newborn rats exposed 90% oxygen...
Indoleamine 2,3-dioxygenase (IDO), with an immunoregulatory effect related to tryptophan metabolism, has emerged as attractive target for cancer immunotherapy. Here, a polymeric IDO inhibitor based on the poly(ethylene glycol)-b-poly(L-tyrosine-co-1-methyl-D-tryptophan) copolymer (PEG-b-P(Tyr-co-1-MT)) was developed facile trident PEG-b-P(Tyr-co-1-MT) could self-assemble into nanoparticles (NPs), which were subject enzyme degradation and capable of retarding metabolism L-tryptophan (TRP)...
The lung microbiota have been found to be substantially altered in numerous pulmonary disorders, and crosstalk between the host pathophysiology plays critical roles regulation of disease states. aim this study was investigate dynamic changes during different stages acute injury respiratory distress syndrome (ALI/ARDS). Rats receiving an intraperitoneal administration lipopolysaccharide (LPS) were sacrificed at 12 48 h after injection, hematological parameters, serum cytokine levels,...
RIG-I-like (where RIG-I is retinoic acid inducible gene I) receptor LGP2 laboratory of genetics and physiology) an important intracellular that recognizes viral RNAs in innate immunity, but its origin evolution remains unknown. Here we clearly demonstrate the presence a receptor, BjLGP2, basal chordate amphioxus. It predominantly expressed hepatic caecum hindgut, upregulated following challenge with poly(I:C). BjLGP2 distributed cytoplasm both grouper spleen flounder gill (FG) cells,...
Analyses of the levels mRNAs encoding IFIT1, IFI16, RIG-1, MDA5, CXCL10, LGP2, PUM1, LSD1, STING, and IFNβ in cell lines from which gene PML, HDAC4, IRF3, or HDAC 1 had been knocked out, as well ability these to support replication HSV-1, revealed following: (i) Cell lacking HDAC4 (cluster 1) exhibited increased expression partially overlapping networks. Concurrently, produced 5 fold 12 lower yields HSV-1 than parental cells. (ii) genes 2) decreased virus that did not differ those by line....
Background: Ceftiofur is an effective antibiotic against respiratory infections in livestock. However, ceftiofur concentration that found lungs after intravenous injection not effective. Fortunately, ceftiofur-loaded gelatin microsphere (Cef-MS) enjoys advantages of lung-targeting and can achieve concentration. no study has been reported on this modality drug delivery.Objective: We investigated the properties delivery modality—lung targeting ceftiofur-Cef-MSs.Methods: prepared Cef-MS...