A5023255066- Ovarian cancer diagnosis and treatment
- Acute Myeloid Leukemia Research
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Endometrial and Cervical Cancer Treatments
- Immune Cell Function and Interaction
- Histone Deacetylase Inhibitors Research
- T-cell and B-cell Immunology
- interferon and immune responses
- Neonatal Health and Biochemistry
- Immunotherapy and Immune Responses
- Pancreatic and Hepatic Oncology Research
- Inflammatory Biomarkers in Disease Prognosis
- Cancer-related gene regulation
- Blood groups and transfusion
- Mitochondrial Function and Pathology
- Hemoglobinopathies and Related Disorders
- Endometriosis Research and Treatment
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Liver Disease Diagnosis and Treatment
- Gold and Silver Nanoparticles Synthesis and Applications
- RNA Research and Splicing
- Immune cells in cancer
- Lung Cancer Treatments and Mutations
Fujian Medical University
2017-2025
Union Hospital
2017-2025
First Affiliated Hospital of Zhengzhou University
2024
Zhengzhou University
2023
Northwest Women's and Children's Hospital
2019-2022
Fuzhou Maternity and Child Health Care Hospital
2022
Peking Union Medical College Hospital
2008
Chinese Academy of Medical Sciences & Peking Union Medical College
2008
Abstract Regulatory T (T reg ) cells are a distinct T-cell lineage characterized by sustained Foxp3 expression and potent suppressor function, but the upstream dominant factors that preserve lineage-specific features mostly unknown. Here, we show Lkb1 maintains cell identity stabilizing enforcing function. Upon receptor (TCR) stimulation protein is upregulated in not conventional cells. Mice with cell-specific deletion of develop fatal early-onset autoimmune disease, no most stabilizes...
Human FOXP3
To balance immunity and tolerance, the endogenous pool of Foxp3+ regulatory T (Treg) cells is tightly controlled, but underlying mechanisms this control remain poorly understood. Here we show that number Treg negatively regulated by kinase Lkb1 in dendritic (DCs). Conditional knockout gene DCs leads to excessive cell expansion multiple organs dampens antigen-specific immunity. Lkb1-deficient are capable enhancing, compared with wild-type DCs, proliferation via cell-cell contact involving...
Abstract Diffuse large B-cell lymphoma (DLBCL), an invasive with substantial heterogeneity, can be mainly categorised into germinal centre B-cell-like (GCB) and non-GCB subtypes. DLBCL cells are highly susceptible to ferroptosis, which offers effective avenue for treating recurrent refractory DLBCL. Moreover, various heat shock proteins involved in regulating the sensitivity of tumour ferroptosis. Among these proteins, tailless complex polypeptide 1 (TCP1), a subunit chaperonin-containing...
Although melatonin has been shown to exert marked antitumor effects against a variety of cancers, the underlying mechanisms remain be fully elucidated. It hypothesized that anticancer properties are associated with its ability suppress epithelial‑to‑mesenchymal transition (EMT) cancer cells. In present study, effectively suppressed interleukin (IL)‑1β‑induced EMT in human gastric adenocarcinoma (GA) Sequential treatment GA cells after IL‑1β challenge markedly reversed IL‑1β‑induced...
Acute myeloid leukemia (AML), an aggressive hematopoietic malignancy, exhibits poor prognosis and a high recurrence rate largely because of primary secondary drug resistance. Elevated serum IL6 levels have been observed in patients with AML are associated chemoresistance. Chemoresistant cells highly dependent on oxidative phosphorylation (OXPHOS), mitochondrial network remodeling is essential for function. However, IL6-mediated regulation its effectiveness as therapeutic target remain...
Hsa_circ_0001756 was reported to be upregulated in serum samples of ovarian cancer (OC) patients and may serve as a potential OC biomarker. This study aimed investigate the role molecular mechanisms hsa_circ_0001756 procession. Herein, we detected expression tissues cell lines with RT-qPCR assay, which showed that lines. Then small interfering RNA targeting (si-hsa_circ_0001756) transfected into SKOV3 A2780 cells, proliferation, invasion, epithelial-mesenchymal transition (EMT) marker...
Abstract Acute myeloid leukemia (AML) cell survival and chemoresistance are influenced by the existence of bone marrow mesenchymal stem cells (BMMSCs); however, pathways which BMMSCs contribute to these processes remain unclear. We earlier revealed that methyltransferase-like 3 (METTL3) expression is significantly reduced in AML METTL3 mediates BMMSC adipogenesis promote human lines vitro. In this investigation, we evaluated function vivo. Mice exhibiting a conditional removal Mettl3 were...
Hepatocellular carcinoma (HCC) represents the second highest cause of cancer-associated deaths worldwide, and hepatitis B virus (HBV) infection is a major risk factor. Here, we aimed to identify genetic signatures HBV-positive (HBV+) HCC uncover potential carcinogenic mechanisms.Gene expression profiles 124 samples, including tumor non-tumor tissues were subjected bioinformatics analysis. The levels thymidylate synthase (TYMS) CDC45 in patients' samples validated by immunohistochemistry...
Bioengineered marine microalgae Schizochytrium sp. is currently used to produce docosahexaenoic acid (DHA). However, following DHA extraction, the remaining protein-rich materials are not well utilized. In this study, we report that bioengineered hydrolysate (MESH), which exhibits a unique peptide profile as identified by Ultra Performance Liquid Chromatography coupled with Q-TOF mass spectrometry(UPLC/Q-TOF-MS), ameliorated bowel inflammation in mice. mouse model of experimentalcolitis...
Objective This study aimed to determine the association of asymptomatic sexually transmitted infections (STIs), including Ureaplasma urealyticum (UU), Mycoplasma hominis (MH), genitalium, Chlamydia trachomatis, and herpes simplex virus type 2, with high-risk human papillomavirus (hrHPV) in cervical intraepithelial lesions neoplasms. Methods A total 320 hrHPV-positive 160 hrHPV-negative women were divided into high-grade squamous lesion (HSIL) + invasive cancer low-grade normal subgroups,...
Alveolar macrophages (AMs) are pivotal for maintaining lung immune homeostasis. We demonstrated that deletion of liver kinase b1 (Lkb1) in CD11c+ cells led to greatly reduced AM abundance the due impaired self-renewal AMs but not impeded pre-AM differentiation. Mice with Lkb1-deficient exhibited deteriorated diseases during airway Staphylococcus aureus (S. aureus) infection and allergic inflammation, excessive accumulation neutrophils more severe pathology. Drug-mediated depletion...
We aimed to evaluate whether the systemic inflammatory response index (SIRI) and platelet lymphocyte ratio (PLR) are associated with ovarian malignancy their diagnostic value. Design: This retrospective study compared SIRI, PLR, cancer antigen 125 (CA125), 153 (CA153), 199 (CA199), A carcinoma embryonic (CEA) alpha fetal protein (AFP) of two groups in Fujian Maternity Child Health Hospital, Affiliated Hospital Medical University from January 2018 December 2020, divided into based on...
Background:The prognostic significance of the red blood cell distribution width to albumin ratio (RAR) spans various diseases, yet its utility as a biomarker for hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) remains unclear.Methods: We retrospectively studied 1,413 patients with HBV-HCC.Receiver operating characteristic curves identified optimal RAR cut-offs, stratifying into H-RAR and L-RAR groups.Propensity score matching helped balance baseline characteristics.We further...
Objectives: Red blood cell distribution width (RDW) is a widely used clinical parameter recently deployed in predicting various cancers.This study aimed to evaluate the prognostic value of RDW patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC).Methods: We conducted retrospective 745 HBV-related HCC, 253 chronic (CHB), and 256 healthy individuals compare their hematological parameters analyze levels.Potential risk factors for long-term all-cause mortality HCC were...