A5101856026- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- interferon and immune responses
- Glioma Diagnosis and Treatment
- Cancer-related gene regulation
- Ferrocene Chemistry and Applications
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Histone Deacetylase Inhibitors Research
- Cancer Mechanisms and Therapy
- Kruppel-like factors research
- Ferroptosis and cancer prognosis
- Macrophage Migration Inhibitory Factor
- Ubiquitin and proteasome pathways
- Hepatocellular Carcinoma Treatment and Prognosis
- Electrocatalysts for Energy Conversion
- T-cell and Retrovirus Studies
- NF-κB Signaling Pathways
- Polyoxometalates: Synthesis and Applications
- Endoplasmic Reticulum Stress and Disease
- Mesoporous Materials and Catalysis
- Cancer Cells and Metastasis
Southern University of Science and Technology
2022-2025
Shantou University
2025
Shantou University Medical College
2025
Ministry of Education of the People's Republic of China
2022-2024
Sun Yat-sen University
2017-2024
The First Affiliated Hospital, Sun Yat-sen University
2022-2024
Nanjing Agricultural University
2010-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Sichuan University
2023-2024
Southwest University
2023
Breast cancer (BC) has a marked tendency to spread the bone, resulting in significant skeletal complications and mortality. Recently, circular RNAs (circRNAs) have been reported contribute initiation progression. However, function mechanism of circRNAs BC bone metastasis (BC-BM) remain largely unknown.Bone-metastatic were screened using deep sequencing validated situ hybridization tissues with or without metastasis. The role circIKBKB inducing pre-metastatic niche formation was determined...
Magnetite nanoparticles were fabricated using a biopolymer (sodium alginate)-assisted route via redox-based hydrothermal method FeCl3·6H2O and urea as the starting materials. The morphology, composition, phase structure of as-prepared powders characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), photoelectron spectroscopy (XPS). results show that plays dual roles, reduction, stabilization, in formation products. This can be easily controlled is expected to applicable...
Abstract Background The plasticity of cancer stem cells (CSCs)/tumor-initiating (T-ICs) suggests that multiple CSC/T-IC subpopulations exist within a tumor and oncogenic pathways collaborate to maintain the state. Here, we aimed identify potential therapeutic targets concomitantly regulate T-IC CSC/T-IC-associated pathways. Methods A chemoresistant patient-derived xenograft (PDX) model human esophageal squamous cell carcinoma (ESCC) was employed microRNAs contribute ESCC aggressiveness....
It has been reported that the transcription factor activating enhancer-binding protein 4 (TFAP4) is upregulated and associated with an aggressive phenotype in several cancers. However, precise mechanisms underlying oncogenic role of TFAP4 remain largely unknown. Methods: expression levels hepatocellular carcinoma (HCC) cells tissues were detected by quantitative real-time PCR (qPCR) immunohistochemistry (IHC). In vitro vivo assays performed to investigate function tumor-initiating cell...
Mitochondrial dynamics play vital roles in the tumorigenicity and malignancy of various types cancers by promoting tumor-initiating potential cancer cells, suggesting that targeting crucial factors drive mitochondrial may lead to promising anticancer therapies. In current study, we report overexpression fission factor (MFF), which is upregulated significantly liver cancer-initiating cells (LCIC), promotes enhances stemness capability non-LCICs. MFF-induced evoked mitophagy asymmetric stem...
Abstract Sustaining DNA damage response (DDR) signalling via retention of DDR factors at damaged sites is important for transmitting damage-sensing and repair signals. Herein, we found that provoked the association ribosomes with IRES region in lncRNA CTBP1-DT, which overcame negative effect upstream open reading frames (uORFs), elicited novel microprotein damage-upregulated protein (DDUP) translation a cap-independent mechanism. Activated ATR kinase-mediated phosphorylation DDUP induced...
Abstract Purpose: The development of resistance to platinum-based chemotherapy remains the unsurmountable obstacle in cancer treatment and consequently leads tumor relapse. This study aims investigate mechanism by which loss RBMS3 induced chemoresistance epithelial ovarian (EOC). Experimental Design: FISH IHC were used determine deletion frequency expression 15 clinical EOC tissues 150 clinicopathologically characterized specimens. effects CBP/β-catenin antagonist PRI-724 examined clone...
BackgroundAberrant fatty acid (FA) metabolism is a unique vulnerability of cancer cells and may present promising target for therapy. Our study aims to elucidate the molecular mechanisms by which NKX2–8 deletion reprogrammed FA metabolism-induced chemoresistance in epithelial ovarian (EOC).MethodsThe frequency expression 144 EOC specimens were assayed using Fluorescence situ hybridization immunochemical assays. The effects oxidation (FAO) antagonist Perhexiline on examined Annexin V colony...
Abstract Tumor‐derived extracellular vesicles (EVs) function as critical mediators in selective modulation of the microenvironment distant organs to generate a pre‐metastatic niche that facilitates organotropic metastasis. Identifying organ‐specific molecular determinants EVs can develop potential anti‐metastatic therapeutic targets. In current study, large oncosomes (LOs), atypically cancer‐derived EVs, are found play crucial role facilitating bone‐tropic metastasis hepatocellular carcinoma...
Microvascular invasion (MVI) is a major unfavorable prognostic factor for intrahepatic metastasis and postoperative recurrence of hepatocellular carcinoma (HCC). However, the intervention preoperative prediction MVI remain clinical challenges due to absent precise mechanism molecular marker(s). Herein, we aimed investigate mechanisms underlying vascular that can be applied in HCC.
Proteasome is an essential organelle responsible for maintaining cellular protein homeostasis, but its relationship with DNA methylation remains unknown. In this study, we assessed of colorectal cancer (CRC) cells following treatment proteasome inhibitors, and investigated the underlying mechanism changes biological effects on CRC cells. We established that inhibition leads to significant alterations in profile by suppressing synthesis methyltransferases (DNMTs). found treating inhibitors...
Blocking genotoxic stress-induced NF-κB activation would substantially enhance the anticancer efficiency of chemotherapy. Unlike well-established classical pathway, agents-induced "nuclear-to-cytoplasmic" pathway is initiated from nucleus and transferred to cytoplasm. However, mechanism linking nuclear DNA damage signaling cytoplasmic IKK remains unclear. Here, we report that TRIM37, a novel E3 ligase, plays vital role in via monoubiquitination NEMO at K309 nucleus, consequently resulting...
Abstract The mechanisms underlying how cells subjected to genotoxic stress reestablish reduction-oxidation (redox) homeostasis scavenge stress-induced reactive oxygen species (ROS), which maintains the physiological function of cellular processes and cell survival, remain unclear. Herein, we report that, via a TCF-independent mechanism, induces enrichment β-catenin in chromatin, where it forms complex with ATM phosphorylated-JDP2 PRMT5. This elicits histone H3R2me1/H3R2me2s-induced...
Melatonin shows therapeutic benefits in gastric cancer, but the mechanism underlying its anticancer effects remains elusive. The aim of this study was to determine whether melatonin inhibits lung metastasis cancer.A model cancer established nude mice injected with human adenocarcinoma MGC80-3 cells. Mice were divided into control, IL-1β-treated, melatonin-treated, and IL-1β plus melatonin-treated groups analyzed for formation metastatic nodules by flow cytometry hematoxylin eosin staining....
Temporal lobe epilepsy (TLE) is a common neurological disorder, which characterized by recurrent spontaneous seizures. Exploring the mechanisms of epileptogenesis has been considered as priority. The aim this study to investigate effects LncRNA MEG3 in epileptiform discharges (SREDs) and rats with TLE.Rat model TLE was produced intraperitoneal injection lithium chloride pilocarpine. Rat hippocampal neuronal SREDs established Mg2+-free treatment. overexpressed transfection AAV-MEG3 model....
Abstract The incidence of bone metastases in hepatocellular carcinoma (HCC) has increased prominently over the past decade owing to prolonged overall survival HCC patients. However, mechanisms underlying bone‐metastasis remain largely unknown. In current study, HCC‐secreted lectin galactoside‐binding soluble 3 (LGALS3) is found be significantly upregulated and correlates with shorter bone‐metastasis‐free Overexpression LGALS3 enhances metastatic capability cells induces skeletal‐related...