A5068588368- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Testicular diseases and treatments
- Endometriosis Research and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Cervical Cancer and HPV Research
- Uterine Myomas and Treatments
- Reproductive Biology and Fertility
- Cancer-related molecular mechanisms research
- Cancer Risks and Factors
- Sarcoma Diagnosis and Treatment
- Reproductive System and Pregnancy
- Ovarian function and disorders
- Multiple and Secondary Primary Cancers
- Urologic and reproductive health conditions
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Breast Cancer Treatment Studies
- Epigenetics and DNA Methylation
- Cancer Treatment and Pharmacology
- Neuroblastoma Research and Treatments
- Renal cell carcinoma treatment
- Chromatin Remodeling and Cancer
- Extracellular vesicles in disease
- Kruppel-like factors research
Peking Union Medical College Hospital
2015-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Becton Dickinson (United States)
2023
National Clinical Research
2022
National Clinical Research Center for Digestive Diseases
2022
Yang Hospital
2020
Academy of Medical Sciences
2015-2018
Academia Sinica
2018
Directorate-General for Interpretation
2016
National Natural Science Foundation of China
2016
The objective of this study was to compare the efficacy and safety trabectedin plus pegylated liposomal doxorubicin (PLD) with that PLD alone in women recurrent ovarian cancer after failure first-line, platinum-based chemotherapy.Women > or = 18 years, stratified by performance status (0 1 v 2) platinum sensitivity, were randomly assigned receive an intravenous infusion 30 mg/m(2) followed a 3-hour 1.1 every 3 weeks 50 4 weeks. primary end point progression-free survival (PFS) independent...
// Huimin Bai 1, 2, * , Haixia Li Weihua 1 Ting Gui Jiaxin Yang Dongyan Cao Keng Shen Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy Sciences & College, Beijing China 2 Chao-Yang Capital University, These authors have contributed equally to this work Correspondence to: Cao, e-mail: caodongyan@pumch.cn Shen, shenkeng@vip.sina.com skpumch@126.com Keywords: ovarian cancer, intratumoral heterogeneity, cell subclones, invasion migration, RNA-Seq...
Cellular exosomes are involved in many disease processes and have the potential to be used for diagnosis treatment. In this study, we compared characteristics of derived from human ovarian epithelial cells (HOSEPiC) three cancer cell lines (OVCAR3, IGROV1, ES-2) investigate differences between originating normal malignant cells. Two established colloid-chemical methodologies, electron microscopy (EM) dynamic light scattering (DLS), a relatively new method, nanoparticle tracking analysis...
Circular RNAs (circRNAs) are regarded as a novel class of widespread endogenous non-coding RNAs, which may play important roles in tumorigenesis by regulating gene expression. Nevertheless, the characterization circRNAs epithelial ovarian cancer (EOC) remains largely unknown. This study aimed to investigate circRNA expression profiles EOC. A total 54 EOC specimens and normal tissues (controls) were collected. circRNA-sequencing based identified 4 compared with tissues. data validated reverse...
Ovarian cancer is the most lethal of gynecological malignancies. Fourier Transform Infrared (FTIR) spectroscopy has gradually developed as a convenient, inexpensive and non-destructive technique for study many diseases. In this study, FTIR spectra normal several heterogeneous ovarian cell lines well tissue samples were compared in spectral region 4000 cm- 1 - 600 1.Cell collected from human surface epithelial line (HOSEpiC) five (ES2, A2780, OVCAR3, SKOV3 IGROV1). Validation performed on...
The present study aimed to identify the stem cell characteristics of side population (SP) cells sorted from widely-used HeLa human cervical carcinoma line. SP were line using fluorescence-activating sorting (FACS). Stem cells, including proliferation, self-renewal, differentiation and ability form xenografts, investigated in vitro vivo. demonstrated strong tumorigenesis following vivo transplantation into five six-week-old female Balb/c mice. observed be more resistant chemotherapy...
Fertility-sparing surgery is indicated for patients with stage I epithelial ovarian cancers. We sought to evaluate the clinical outcomes and oncofertility in a cohort of reproductive age cancer (EOC). Overall, 108 (≤ 40 years) diagnosed EOC who were treated at Peking Union Medical College Hospital between 1999 2013 included study. The Kaplan-Meier model Cox regression analyses used survival analysis. type fertility-sparing (FSS) (48.1%) radical (RS) (51.9%). After median follow-up 83 months,...
Introduction: Ovarian cancer is a highly malignant with poor prognosis. At present, there no accurate strategy for predicting the prognosis of ovarian cancer. A prediction signature associated DNA repair genes in was explored this study. Methods: Gene expression profiles were downloaded from GEO, UCSC, and TCGA databases. Cluster analysis, univariate stepwise regression used to identify as potential targets prognostic survival prediction. The top evaluated by immunohistochemical staining...
Introduction: Endometrial cancer is one of the most common uterine cancers worldwide. AKT reported to regulate progesterone receptor B dependent transcription and angiogenesis in endometrial cancer. However, potential mechanisms tumor progression remain unclear. Methods: We used GSE72708 with gene expression profiles regulation from GEO database. performed GSEA analysis explore pathway enrichments. found that upregulated enriched pathways siAKT group were associated acid metabolism immune...
Owing to the rarity of sex cord tumor with annular tubules (SCTAT), it is difficult recognize SCTAT clinically and there no standard treatment. The aim our study was investigate treatment outcomes prognosis patients ovarian SCTAT.A cohort 13 diagnosed treated in Peking Union Medical College Hospital studied. Data on clinicopathological characteristics, treatment, were retrospectively reviewed analyzed.SCTAT accounted for 1.4% stromal tumors, an average onset age 22.6 years. All presented...
Background A few inflammatory markers were studied to evaluate their possible prognostic roles in various cancers. The neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte are hypothesized reflect the systemic inflammation. objective of present study was investigate whether or not pretreatment can predict survival patients with cervical cancer treated neoadjuvant chemotherapy radical hysterectomy. Methods We performed a retrospective on (FIGO stage Ib2-IIb) who had undergone...