A5046238628- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Testicular diseases and treatments
- Cervical Cancer and HPV Research
- Intraperitoneal and Appendiceal Malignancies
- Gynecological conditions and treatments
- Ovarian function and disorders
- Sarcoma Diagnosis and Treatment
- Renal cell carcinoma treatment
- Reproductive Biology and Fertility
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Cancer Risks and Factors
- Neuroendocrine Tumor Research Advances
- Gestational Trophoblastic Disease Studies
- Soft tissue tumors and treatment
- Estrogen and related hormone effects
- Chromatin Remodeling and Cancer
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Urologic and reproductive health conditions
- Cancer, Lipids, and Metabolism
Peking Union Medical College Hospital
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
National Clinical Research Center for Digestive Diseases
2021-2024
National Clinical Research
2021-2024
Academia Sinica
2022
Fudan University Shanghai Cancer Center
2015
Creative Commons
2015
There are limited data comparing the prognosis and fertility outcomes of patients with early cervical cancer treated by trans-vaginal radical trachelectomy (VRT) or abdominal (ART).The objective this study was to compare surgical pathologic characteristics, VRT ART. Matched-case based on a prospectively maintained database underwent in 10 centres China designed Totally 150 cases, 77 73 ART group, were included. provide similar pathological except larger specimens obtained In no patient...
The aim of this study was to evaluate the efficacy and safety with gonadotropin-releasing hormone agonist (GnRHa) combined a levonorgestrel-releasing intrauterine system or an aromatase inhibitor (letrozole) in young women well-differentiated early endometrial carcinoma (EC) complex atypical hyperplasia (CAH).We performed retrospective analysis including clinical characteristics 29 patients younger than 45 years endometrioid adenocarcinoma uterus CAH who were treated at Department Obstetrics...
Fertility-sparing surgery is indicated for patients with stage I epithelial ovarian cancers. We sought to evaluate the clinical outcomes and oncofertility in a cohort of reproductive age cancer (EOC). Overall, 108 (≤ 40 years) diagnosed EOC who were treated at Peking Union Medical College Hospital between 1999 2013 included study. The Kaplan-Meier model Cox regression analyses used survival analysis. type fertility-sparing (FSS) (48.1%) radical (RS) (51.9%). After median follow-up 83 months,...
Introduction: Endometrial cancer is one of the most common uterine cancers worldwide. AKT reported to regulate progesterone receptor B dependent transcription and angiogenesis in endometrial cancer. However, potential mechanisms tumor progression remain unclear. Methods: We used GSE72708 with gene expression profiles regulation from GEO database. performed GSEA analysis explore pathway enrichments. found that upregulated enriched pathways siAKT group were associated acid metabolism immune...
Around 4% of women receive an endometrial cancer diagnosis before turning 40, mainly those without prior childbirth experience and a strong desire to preserve their ability conceive. Consequently, for young patients diagnosed with atypical hyperplasia (AEH) or early carcinoma (EC), fertility-preserving approach employing high-dose oral progesterone has been adopted. However, previous research shown notable relapse rate. Furthermore, the extended use substantial doses may hinder ovarian...
To provide a comprehensive understanding and propose strategy for the management of extragonadal malignant germ cell tumors (EMGCTs) arising from extracranial nonvaginal sites. We retrospectively reviewed cases 12 patients with EMGCTs sites treated in our center over past 38 years. Data on clinicopathological characteristics, treatment modalities, follow-up information were analyzed. Among 209 diagnosed EMGCTs, women (5.7%) identified. These had sacrococcygeal region (n = 4), abdominal...
Owing to the rarity of sex cord tumor with annular tubules (SCTAT), it is difficult recognize SCTAT clinically and there no standard treatment. The aim our study was investigate treatment outcomes prognosis patients ovarian SCTAT.A cohort 13 diagnosed treated in Peking Union Medical College Hospital studied. Data on clinicopathological characteristics, treatment, were retrospectively reviewed analyzed.SCTAT accounted for 1.4% stromal tumors, an average onset age 22.6 years. All presented...
The aim of this study is to evaluate the accuracy magnetic resonance imaging (MRI) in preoperative assessments primary tumor size, parametrial invasion, and pelvic lymph node metastasis patients with early-stage cervical cancer.A cohort 125 International Federation Gynecology Obstetrics stage IA2 IIA cancer who had MRI underwent radical hysterectomy were enrolled analyzed. scan examination measurement size was assessed based on postoperative pathologic findings. detection status invasion...
To assess the clinical outcomes and fertility of young women with stage I low-grade endometrial stromal sarcoma (ESS) treated fertility-sparing surgery.Seventeen patients ESS (stage IA, n = 6; IB, 11) were entered into this study. Adjuvant hormone therapy was administered to 15 (88.2%) patients. At a median follow-up 39 months (range, 4-106 months), 10 (58.8%) developed recurrence. All had IB disease; among them, first recurrence limited uterus observed in 6 17 alive disease-free at time...
Endometrial intraepithelial neoplasia (EIN), also known as endometrial atypical hyperplasia (EAH) is believed to be the precursor lesion of endometrioid carcinoma (EEC). Many genetic factors play important roles in process carcinogenesis, however, key alterations from dysplasia cancer remains poorly understood. Germline mutations Lynch syndrome genes are associated with hereditary carcinoma. The role other susceptibility unclear. aim this study was investigate genomic premalignant and EEC,...
Abstract Endometrial cancer is highly malignant and has a poor prognosis in the advanced stage, thus, prediction of its important. DNA methylation rapidly gained clinical attention as biomarker for diagnostic, prognostic predictive purposes various cancers. In present study, differentially methylated positions expressed genes were identified according to RNA-Seq data. Functional analyses interaction network performed identify hub genes, overall survival analysis validated. The top evaluated...
Abstract Objective To evaluate the efficacy and safety of PLD in treating patients who experience epithelial ovarian, fallopian tubal, peritoneal cancer progression within 12 months after first-line platinum-based therapy. Methods This was an open-label, single-arm multicenter clinical trial. The ORR interim primary objective, DCR, AEs QOL were secondary objectives. impact factors on outcomes, change trend CA125 artificial platinum-free interval exploratory endpoints. Results Totally, 115...