A5062442867- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Cancer-related molecular mechanisms research
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Reproductive System and Pregnancy
- Cancer Mechanisms and Therapy
- Pregnancy and preeclampsia studies
- Cancer Risks and Factors
- Maternal and fetal healthcare
- RNA Interference and Gene Delivery
- Ginseng Biological Effects and Applications
- Circular RNAs in diseases
- Cytokine Signaling Pathways and Interactions
- Gynecological conditions and treatments
- Epigenetics and DNA Methylation
- Estrogen and related hormone effects
- Reproductive tract infections research
- Genetic factors in colorectal cancer
- Antifungal resistance and susceptibility
- Cancer Research and Treatments
- Intraperitoneal and Appendiceal Malignancies
- CAR-T cell therapy research
- Lipid metabolism and disorders
- Kruppel-like factors research
Southwest University
2025
Second Affiliated Hospital of Jilin University
2014-2023
Jilin University
2007-2023
Peking Union Medical College Hospital
2017
Chinese Academy of Medical Sciences & Peking Union Medical College
2017
Bethune Second Hospital
2012
Daqing Oilfield General Hospital
2010
Guangdong Pharmaceutical University
2008
Jilin Province Tumor Hospital
2007
The mechanisms underlying cisplatin resistance in tumors are not fully understood. Previous studies have reported that cellular to oxidative stress is accompanied by cisplatin. However, the relationship between and drug human ovarian cancer cells (HOCCs) clear. Here, we reveal a critical role for multifunctional protein p62/SQSTM1 (HOCCs). (sequestosome 1) plays important roles cell differentiation, proliferation as an antiapoptotic molecule. We found cisplatin-resistant SKOV3/DDP express...
Ginsenosides are main components extracted from ginseng, and ginsenoside Rg3 is one of the most important parts. Ginsenoside has been found to inhibit several kinds tumor growth metastasis. The present study was undertaken investigate effect on human ovarian cancer metastasis possible mechanism.The experimental lung models SKOV-3 assay tumor-induced angiogenesis were used observe inhibitory effects angiogenesis. invasive ability cells in vitro detected by Boyden chamber, immunofluorescence...
Background Ginsenoside Rg3, the main component isolated from ginseng, inhibits some kinds of tumour growth and angiogenesis. The combination low dose chemotherapy antiangiogenesis inhibitors suppresses experimental tumours more effectively than conventional therapy. effect this on ovarian cancer remains to be evaluated. Therefore, we investigated synergism ginsenoside Rg3 cyclophosphamide (CTX) angiogenesis human cancer. Methods Twenty-eight female athymic mice were divided randomly into 4...
Objectives Studies have reported the significance of circulating microRNAs (miRNAs) as biochemical markers cancer. Few reports demonstrate miRNAs in serum patients with ovarian epithelial carcinoma (EOC). The present study prospectively investigated status miRNA-92 (miR-92) EOC and healthy controls, examined potential usefulness this molecule a biomarker for diagnosis. Methods Levels miR-92 samples from controls were measured by quantitative real time reverse transcription–polymerase chain...
Ovarian cancer's poor progression is closely associated with overexpression of matrix metalloproteinase 9 (MMP-9), which belongs to the class enzymes believed be involved in degradation extracellular matrix. However, mechanisms underlying regulation MMP-9 are not completely understood. STAT (signal transducer and activator transcription) family transcription factors well known engaged diverse cellular functions. Activation STAT3 has been observed a number cancers, promoting tumorigenesis...
Abstract Objective To evaluate the efficacy and safety of PLD in treating patients who experience epithelial ovarian, fallopian tubal, peritoneal cancer progression within 12 months after first-line platinum-based therapy. Methods This was an open-label, single-arm multicenter clinical trial. The ORR interim primary objective, DCR, AEs QOL were secondary objectives. impact factors on outcomes, change trend CA125 artificial platinum-free interval exploratory endpoints. Results Totally, 115...
A growing body of evidence suggests that microRNA-494 (miR-494) could act as tumor-suppressive or oncogenic microRNAs (miRNAs) in different types tumors. However, the biological roles and underlying mechanisms miR-494 remain unknown human epithelial ovarian carcinoma (EOC). Therefore, aims this study were to investigate expression significance its clinical diagnosis patients suffering EOC analyze role molecular mechanism on carcinogenesis EOC. Here, we found was significantly decreased cell...
Abstract Aim Recent studies have demonstrated that the neural precursor cell expressed, developmentally downregulated 4‐like (Nedd4L) gene plays a role in progression of various cancers. However, reports describing Nedd4L expression ovarian cancer tissues are limited. Material and Methods A cohort ( n = 117) archival formalin‐fixed, paraffin embedded resected normal epithelial 10), benign tumor serous borderline 14), mucous 11), invasive 72) were assessed for protein using...
Due to the success of chimeric antigen receptors (CARs) in hematological tumors, CARs are also being studied treat solid tumors. Improving ability penetrate tumor tissues is one biggest challenges. As most malignant cancer female reproductive system, survival rate ovarian has not been significantly improved by traditional therapy methods; therefore, it necessary develop new therapeutic targets and immunotherapy methods for cancer. UPAR a glysocylphosphatidylinositol (GPI) anchoring membrane...
Preoperative neoadjuvant chemotherapy (NACT) has been widely used in developing countries for the treatment of patients with International Federation Gynecology and Obstetrics (FIGO) stages IB3 IIA2 cervical cancer. However, effectiveness NACT options NACT-insensitive have concerning. This study will assess prognostic differences between primary surgery (PST), determine factors associated prognosis, explore better adjuvant modalities patients.
The aim of the study was to investigate suppressive effects pSilencer2.1-U6-siRNA-stat3 recombinant plasmids on growth ovarian cancer in vitro. MATERIAL AND METHODS.: Three pairs DNA template (stat3-1, stat3-2, stat3-3) specific for different target sites stat3 mRNA were synthesized reconstruct pSilencer2.1-U6-siRNA-stat3s, which transfected into SKOV3 cells. expressions STAT3, BcL-2, cyclin D1 and C-myc these cells detected by Western blot Northern blot. cell cycle determined flow cytometry...
X-box-binding protein 1-transfected neural stem cells were transplanted into the right lateral ventricles of rats with rotenone-induced Parkinson's disease. The survival capacities and differentiation rates expressing dopaminergic marker tyrosine hydroxylase higher in compared to non-transfected cells. Moreover, dopamine 3,4-dihydroxyphenylacetic acid levels substantia nigra significantly increased, α-synuclein expression was decreased, neurological behaviors ameliorated following...
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder in women of reproductive age and commonly complicated by adverse endometrial outcomes. Long non-coding RNAs (lncRNAs) are class non-protein-coding transcripts that more than 200 nucleotides length. Accumulating evidence indicates lncRNAs involved the development various human diseases. Among these lncRNAs, lncRNA CD36-005 (CD36-005) indicated to be associated with pathogenesis PCOS. However, mechanisms action have not yet...