A5100767689- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Endometriosis Research and Treatment
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Uterine Myomas and Treatments
- RNA modifications and cancer
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Reproductive System and Pregnancy
- Mesenchymal stem cell research
- PARP inhibition in cancer therapy
- Cancer Mechanisms and Therapy
- Immunotherapy and Immune Responses
- Cancer Risks and Factors
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Ferroptosis and cancer prognosis
- Ubiquitin and proteasome pathways
- Pregnancy and preeclampsia studies
- Cancer Immunotherapy and Biomarkers
- Extracellular vesicles in disease
- Renal Diseases and Glomerulopathies
- Epigenetics and DNA Methylation
- Complement system in diseases
Soochow University
2014-2024
First Affiliated Hospital of Soochow University
2014-2024
Huazhong University of Science and Technology
2022
Tongji Hospital
2022
Suzhou Research Institute
2017-2019
Soochow University
2019
Wenzhou Medical University
2010
Zhejiang Taizhou Hospital
2010
Huangshi Central Hospital
2008
Hypoxia and a dense extracellular matrix within the tumor microenvironment can often lead to resistance of tumors radiotherapy. Herein, we use bovine serum albumin (BSA) as template induce growth both gold (Au) nanoclusters manganese dioxide (MnO2) via biomineralization. In obtained BSA-Au-MnO2 composite nanoparticles, Au embedded BSA not only show strong red fluorescence facilitate imaging, but also act radio-sensitizer by absorbing depositing X-ray energy enhance Meanwhile, MnO2 core,...
Healing of full-thickness skin wounds remains a major challenge. Recently, human umbilical cord mesenchymal stem cells (hUC-MSCs) were shown to possess an extraordinary potential promote repair in clinical settings. However, their low survival rate after transplantation limits therapeutic efficiency treating wounds. Hydrogels are considered ideal cell vector owing three-dimensional mesh structure, good biosafety, and biodegradation. The objective this study was investigate the wound healing...
Salt-inducible kinase 2 (SIK2; also known as serine/threonine-protein SIK2) is overexpressed in several cancers and has been implicated cancer progression. However, the mechanisms by which SIK2 regulates cell motility, migration metastasis ovarian have not fully discovered. Here, we identify that promotes vitro vivo. Mechanistically, regulated motility myosin light chain kinase, smooth muscle (MYLK)-meditated phosphorylation of (MYL2). directly phosphorylated MYLK at Ser343 activated its...
The development of smart drug delivery nanocarriers for tumor-targeted and controllable release therapeutic agents is appealing to achieve effective cancer chemotherapy. We herein use CaCO3 nanoparticles as the core load doxorubicin (DOX) direct assembly amphiphilic oxaliplatin prodrugs (Pt(IV)) in presence other commercial lipids. obtained DOX-Pt(IV)-CaCO3-PEG with excellent physiological stability exhibits instant pH-responsive degradation, thus enabling efficient pH-dependent DOX. Via...
Radiotherapy (RT) has been used clinically to overcome cancer in recent decades.
Ovarian cancer is the most lethal gynecologic malignancy worldwide. Olaparib, an inhibitor of poly (ADP-ribose) polymerase (PARP), becoming widely used in ovarian treatment. The overall survival has not been significantly changed over past decades and become increasingly resistant to Olaparib. Ubiquitin-conjugating enzyme E2S (UBE2S) proved promote malignant behaviors many cancers. However, function UBE2S development Olaparib resistance are unclear.In this study, we detected expression...
Long non-coding RNA plasmacytoma variant translocation 1 (PVT1) is a dysregulated gene in malignancy and associated with oncogenesis.In this study, we found PVT1 was an ovarian specific expressing gene, overexpressed multiple cancer types, including (OV).Higher expression levels of are related to shorter survival time OV patients, especially patients advanced stage grade.Recent studies indicated circular also had important role progression, whose roles remain unclear.Knockdown significantly...
In women of reproductive age, severe injuries to the ovary are often accompanied by premature ovarian failure (POF), which can result in amenorrhea or infertility. Hormone replacement therapy has been used treat POF; however, it limited therapeutic efficiency and may cause several side effects. this study, we aimed fabricate a Matrigel scaffold loaded with human umbilical cord-derived mesenchymal stem cells (MSCs) explore its potential restore function repair structures vitro vivo. POF mouse...
Tripartite motif-containing 21 (TRIM21) has been reported to have a cancer-promoting or anticancer effect in various tumors; however, its role ovarian cancer (OC) remains be elucidated. In this study, we explored the biological function of TRIM21 OC progression and investigated potential mechanisms. We found that was remarkably decreased tissues cell lines compared with adjacent-cancerous normal epithelium cell. Decreased expression patients significantly correlated shorter overall...
Uterine leiomyomata (UL) is a common gynecological disease in women. Studied on the relationship between single metabolites of urinary phytoestrogens and UL, especially for combined effects mixed UL still are insufficient.In this cross-sectional study, we included 1,579 participants from National Health Nutrition Examination Survey. Urinary were assessed by measuring excretion daidzein, genistein, equol, O-desmethylangolensin, enterodiol enterolactone. The outcome was defined as UL. Weighted...
Abstract Ovarian cancer (OC) is among the most common and deadly solid malignancies in women. Despite many advances OC research, incidence of continues to rise, its pathogenesis remains largely unknown. Herein, we elucidated function hsa_circ_0061179 OC. The levels hsa_circ_0061179, miR‐143‐3p, TIMELESS, DNA damage repair‐related proteins or normal ovarian tissues cells were measured using real‐time quantitative polymerase chain reaction immunoblotting. biological effects miR‐143‐3p on...
The aim of the present study was to investigate functions RACK1 and its involvement in mechanisms prostate cancer (PC) cell proliferation, invasion metastasis. metastasis stably transfected DU145 cells with evaluated vitro as well vivo following establishment nude mouse models. expression Ki67, RACK1, PTEN androgen receptor (AR) PC detected by immunohistochemical analysis. Our results indicated that promotes vivo. However, knockdown siRNA inhibited migration invasion. downregulation Ki67...
Preoperative neoadjuvant chemotherapy (NACT) has been widely used in developing countries for the treatment of patients with International Federation Gynecology and Obstetrics (FIGO) stages IB3 IIA2 cervical cancer. However, effectiveness NACT options NACT-insensitive have concerning. This study will assess prognostic differences between primary surgery (PST), determine factors associated prognosis, explore better adjuvant modalities patients.
Rationale and ObjectivesHigh-intensity focused ultrasound (HIFU) has been increasingly used for treatment of uterine leiomyoma. The superiority HIFU therapy targeting leiomyoma blood vessels, however, still needs to be further explored. This study aims evaluate the long-term efficacy fibroid devascularization with ultrasound-guided (USgHIFU) effects on ovarian reserve endometrial injury.Materials MethodsFibroid was assessed Adler grade obtained by color Doppler flow imaging power (PDI)....
We aimed to investigate the effect of Kelch-like ECH-associated protein 1/NF-E2 p45-related factor 2 (Keap1/Nrf2) pathway on biological function trophoblast cells in oxidative stress model at cellular level, and analyzed expression level clinical significance Keap1/Nrf2 related antioxidant factors placental tissues Preeclampsia (PE) patients level. In present study, we found that under hypoxia/reoxygenation conditions, activity stress-related enzymes (CAT, GSH-Px, SOD) HTR8/SVneo was...
Hyperthermic intraperitoneal chemotherapy (HIPEC) has been shown to be clinically effective, but the mechanisms by which hyperthermia enhances sensitivity of cells chemotherapeutic drugs not yet elucidated.To identify key molecules involved in thermochemotherapy, this study used mass spectrometry (MS)-based quantitative proteomics technology analyze effects thermochemotherapy on heat-sensitive ovarian cancer cell line A2780. We divided A2780 into four groups, one group served as blank...
To compare the gene expressional levels of receptors for activins and inhibins in ovarian tissues between women with polycystic ovary syndrome (PCOS) normal controls, to analyze their biologically relevant associations serum hormone levels.Total RNA from PCOS (n = 14) controls 21) were isolated during follicular phase menstrual cycle. Real-time PCRs performed examine relative mRNA expression activin receptors, including receptor type IA (ActRIA), IB (ActRIB), IIA (ActRIIA), IIB (ActRIIB),...