A5005636038- Cervical Cancer and HPV Research
- Endometrial and Cervical Cancer Treatments
- Endometriosis Research and Treatment
- Ovarian cancer diagnosis and treatment
- Advanced Sensor and Energy Harvesting Materials
- Uterine Myomas and Treatments
- Conducting polymers and applications
- Nanoplatforms for cancer theranostics
- Urinary and Genital Oncology Studies
- Genital Health and Disease
- Ectopic Pregnancy Diagnosis and Management
- Genetics and Neurodevelopmental Disorders
- Global Cancer Incidence and Screening
- Graphene and Nanomaterials Applications
- Nerve injury and regeneration
- Urological Disorders and Treatments
- Ultrasound and Hyperthermia Applications
- RNA modifications and cancer
- Molecular Biology Techniques and Applications
- Endoplasmic Reticulum Stress and Disease
- Carbon and Quantum Dots Applications
- PARP inhibition in cancer therapy
- Nanoparticle-Based Drug Delivery
- Cancer Immunotherapy and Biomarkers
- Reproductive System and Pregnancy
International Peace Maternity & Child Health Hospital
2022-2025
Shanghai Jiao Tong University
2021-2025
Shanghai Institute of Hematology
2023
Gynecologic Oncology Group
2022
Abstract Background Implementation of high-risk human papillomavirus (hrHPV) screening has greatly reduced the incidence and mortality cervical cancer. However, a triage strategy that is effective, noninvasive, independent from subjective interpretation pathologists urgently required to decrease unnecessary colposcopy referrals in hrHPV-positive women. Methods A total 3251 women aged 30–82 years (median = 41 years) International Peace Maternity Child Health Hospital were included training...
Abstract Tumors often overexpress glucose‐regulated proteins, and agents that interfere with the production or activity of these proteins may represent novel cancer treatments. The chlorpromazine derivative JX57 exhibits promising effects against endometrial minimal extrapyramidal side effects; however, its mechanisms action are currently unknown. Here, protein 75 kD (GRP75) is identified as a direct target using activity‐based profiling loss‐of‐function experiments. findings show GRP75...
Chemodynamic therapy (CDT) relies on the tumor microenvironment (e.g., high H2 O2 level) responsive Fenton-like reactions to produce hydroxyl radicals (·OH) against tumors. However, endogenous is insufficient for effective chemodynamic responses. An NAD(P)H: quinone oxidoreductase 1 (NQO1)high catalase (CAT)low therapeutic window use of NQO1 bioactive drug β-lapachone (β-Lap) first identified in endometrial cancer (EC). Accompanied by NADH depletion, catalyzes β-Lap excess and initiate...
Perineural invasion (PNI) is a new approach of cervical cancer and metastasis, involving the cross-talk between tumor nerve. However, initiating signals cellular interaction mechanisms PNI remain largely elusive. The nerve-sparing radical hysterectomy (NSRH) proposed to improve postoperative quality life only applicable patients without PNI. Therefore, it important elucidate underlying PNI, suggest effective biomarkers predict before NSRH surgery. Here, we found that characteristic advanced...
Rationale and ObjectivesHigh-intensity focused ultrasound (HIFU) has been increasingly used for treatment of uterine leiomyoma. The superiority HIFU therapy targeting leiomyoma blood vessels, however, still needs to be further explored. This study aims evaluate the long-term efficacy fibroid devascularization with ultrasound-guided (USgHIFU) effects on ovarian reserve endometrial injury.Materials MethodsFibroid was assessed Adler grade obtained by color Doppler flow imaging power (PDI)....
We aimed to evaluate changes in ovarian reserve and quality of life women treated with ultrasound-guided high-intensity focused ultrasound (USgHIFU) for uterine fibroids. In this single-center prospective study, a total 69 patients fibroids USgHIFU from October 2018 November 2021 were enrolled. Fibroid volume, anti-Müllerian hormone (AMH) levels, fibroid symptom scores, symptoms (UFS-QOL) questionnaire scores before 1, 3, 6 months after treatment analyzed. Correlations between AMH levels...
Abstract Gadolinium‐based complex contrast agents (GBCAs), frequently applied in magnetic resonance imaging (MRI), are associated with severe acute anaphylactic shock and incurable nephrogenic systemic fibrosis. Besides, the repeated use of GBCAs may result accumulation various tissues. Given these potential adverse effects, have not been well used during pregnancy. Herein, a novel metal‐free T 2 ‐weighted MRI nanoprobe, designated fluorinated small‐sized graphene oxide optimized fluorine...
The aim was to descriptively analyze the clinical characteristics, cytopathology, and outcomes of pregnant patients with high-risk human papillomavirus (HPV) infection. Clinical data 151,516 female HPV infection were retrospectively collected. Baseline data, cervical cytology results, histopathology, types, delivery mode, follow-up recorded for descriptive analysis. A total 157 identified as positive HPV. There 32 (24.2%), 6 (4.5%), 107 (81.1%) cases HPV-16, HPV-18, other respectively....
The impact of para-aortic lymphadenectomy (PALD) on prognosis and quality life (QoL) for IB2-IIA2 cervical cancer patients remain controversial. And whether intraoperative frozen pathology exam common iliac lymph nodes could help predict node (PALN) metastasis was unanswered with high-level evidence.A multi-center, randomized controlled study is intended to investigate the effect PALD QoL in assess value pathological evaluation prediction PALN metastasis. After choosing receive examination...
Endometrial cancer (EC) is one of the most common gynecologic malignancies, which lacking effective drugs for intractable conditions or patients unsuitable surgeries. Recently, patient-derived organoids (PDOs) are found feasible research and drug discoveries. Here, we established a series PDOs from EC performed repurposing screening mechanism analysis treatment. We confirmed that regulatory β subunit methionine adenosyltransferase (MAT2B) highly correlated with malignant progression in...
Abstract Clinical evidence suggests that high‐intensity focused ultrasound (HIFU) is emerging as an increasingly viable non‐invasive treatment for various gynecological diseases, demonstrating both high safety and effectiveness. Nevertheless, HIFU presents challenges in terms of energy dissipation prolonged time during the therapeutic process. In this study, liposomes containing ammonium bicarbonate (NH 4 HCO 3 ) paclitaxel (PTX), a first‐line chemotherapy drug, are utilized to enhance...
Radical hysterectomy (RH) is commonly used to treat early-stage cervical cancer in women of childbearing age and sexual dysfunction due postoperative vaginal shortening a major concern. The impact intraoperative vaginoplasty on prognosis quality life patients with remains controversial lacks high-level evidence. However, there are few reports after RH lengthen vagina patients. This prospective, multi-center, randomized controlled trial aims explore the peritoneal or without ovarian...
The aim of this study is to investigate the role human chorionic gonadotropin (hCG) daily variations and levels prior methotrexate treatment as predictors for outcome.This retrospective included patients who had a sonographically confirmed ectopic pregnancy at International Peace Maternity Child Health Hospital between November 2015 June 2020. associations hCG with success were evaluated by multivariable logistic regression receiver operator characteristic (ROC) curve. Establish nomogram...
Vaginal intraepithelial neoplasia (VaIN) is frequently underdiagnosed. The aim of this study was to explore the clinical characteristics patients with VaIN and identify more sensitive diagnostic methods. This retrospectively analyzed 657 from International Peace Maternal Child Health Hospital during a ten-year period. Among patients, 26.5% were diagnosed 2/3. proportions 2/3 among those who did not undergo hysterectomy 39.5% 24.7%, respectively. sensitivity cytology testing for in only VaIN,...
Abstract Objective : The aim of this study was to explore the clinical characteristics patients with VaIN and identify more sensitive diagnostic methods. Methods This retrospectively analyzed 657 from International Peace Maternal Child Health Hospital in Shanghai during a ten-year period. Results: Among patients, 26.5% were diagnosed 2/3. proportions 2/3 among those who did not undergo hysterectomy 39.5% 24.7%, respectively. sensitivity cytology for only VaIN, concomitant cervical or vulvar...
Evidence highlighted the immune environment as a critical feature in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC). The aim of this study was to characterize relationship between CESC microenvironment. Expression profiles (303 CESCs) clinical data were obtained from Cancer Genome Atlas (TCGA). We divided cases into subtypes performed differential gene expression analysis. Gene Ontology (GO) set enrichment analysis (GSEA) identify potential molecular mechanisms. Data...