A5101506752- Circadian rhythm and melatonin
- Advanced biosensing and bioanalysis techniques
- Genetics, Aging, and Longevity in Model Organisms
- Plant Molecular Biology Research
- Alzheimer's disease research and treatments
- Urinary and Genital Oncology Studies
- Cervical Cancer and HPV Research
- Plant nutrient uptake and metabolism
- Plant Reproductive Biology
- Cancer Research and Treatments
- Cancer Mechanisms and Therapy
- Ovarian cancer diagnosis and treatment
- Protein Interaction Studies and Fluorescence Analysis
- Bioactive Compounds and Antitumor Agents
- Spaceflight effects on biology
- Advanced Nanomaterials in Catalysis
- Selenium in Biological Systems
- Neurobiology and Insect Physiology Research
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cholinesterase and Neurodegenerative Diseases
- PI3K/AKT/mTOR signaling in cancer
- Metal-Organic Frameworks: Synthesis and Applications
- Developmental Biology and Gene Regulation
Chinese PLA General Hospital
2024
Nankai University
2024
Central South University of Forestry and Technology
2024
Central South University
2024
Fujian Medical University
2024
Shanghai Jiao Tong University
2021-2022
Gynecologic Oncology Group
2022
International Peace Maternity & Child Health Hospital
2022
Lanzhou University
2021
Linzi District People's Hospital
2020
Summary Exogenous application of CLAVATA3 (CLV3)/EMBRYO SURROUNDING REGION (CLE) peptides suppresses protophloem differentiation and leads to the consumption proximal root meristem. However, exact CLE corresponding receptor complex regulating have not yet been clarified. Through expression pattern phylogenetic analyses, CLE25/26/45 were identified as candidate peptides. Further genetic physiological assays specific marker observations indicated that CLE25/26/45, BARELY ANY MERISTEM1/3...
Gengnianchun (GNC), a traditional Chinese medicine (TCM), is believed to have beneficial effects on ageing‐related diseases, such as antioxidant properties and against A β ‐induced toxicity. We previously found that GNC extended the lifespan of Caenorhabditis elegans . However, mechanism underlying this effect was unclear. In study, we further explored mechanisms using C. model. significantly increased enhanced oxidative thermal stress resistance. Moreover, chemotaxis after treatment....
Objective. Gengnianchun (GNC), a traditional Chinese medicine (TCM), is primarily used to improve declining functions related aging. In this study, we investigated its prolongevity and stress resistance properties explored the associated regulatory mechanism using Caenorhabditis elegans model. Methods. Wild‐type C. N2 was for lifespan analysis oxidative assays. Transgenic animals were investigate pathways with antioxidative activity. The effects of GNC on levels reactive oxygen species (ROS)...
Alzheimer's disease (AD) is an age-related neurodegenerative disorder, and the few drugs that are currently available only treat symptoms. Traditional medicine or phytotherapy has been shown to protect against AD. In our previous studies, Gengnianchun (GNC), a traditional Chinese formula with prolongevity effect, protected Aβ-induced cytotoxicity in pheochromocytoma cells (PC-12 cells) hippocampal cells. Here, we investigated effects possible mechanisms by which GNC Aβ toxicity using...
To minimize the incidence and mortality of cancer, dye trace method was used to explore mechanism drug inhibition. 60 mice were selected as research objects randomly divided into five groups: model group, shikonin aconitine notoginsenoside R1 compound group. When establishing model, begin administrate medicine by gavage. The permeability lung barrier measured, H.E staining, immunohistochemical Western blot test carried out. results showed that in group had decreased autonomic activity,...
Basilepta melanopus is a pest that severely affects oil tea plants, and the Notch signaling pathway plays significant role in early development of insect ovaries. In this study, we explored function notch gene within reproductive system B. melanopus. The functional domains expression patterns Bmnotch were analyzed. contains 45 epidermal growth factor-like (EGF-like) domains, one negative regulatory region, NODP domain repeat-containing superfamily. qPCR reveals heightened developmental...
Background: Forkhead box protein C2 (FOXC2) is an epithelial-to-mesenchymal transition (EMT)—inducing transcription factor and involved in several cancer developments. In this study, we aimed to investigate the role of FOXC2 ovarian cancer. Methods: A total 13 tissues (11 cases epithelial cancer, one case borderline serous cystadenoma normal tissue) were collected tissue specimens stained detect expression location by immunohistochemistry. Then shRNAs targeting mRNA designed construct...
Vaginal intraepithelial neoplasia (VaIN) is frequently underdiagnosed. The aim of this study was to explore the clinical characteristics patients with VaIN and identify more sensitive diagnostic methods. This retrospectively analyzed 657 from International Peace Maternal Child Health Hospital during a ten-year period. Among patients, 26.5% were diagnosed 2/3. proportions 2/3 among those who did not undergo hysterectomy 39.5% 24.7%, respectively. sensitivity cytology testing for in only VaIN,...
Abstract Objective : The aim of this study was to explore the clinical characteristics patients with VaIN and identify more sensitive diagnostic methods. Methods This retrospectively analyzed 657 from International Peace Maternal Child Health Hospital in Shanghai during a ten-year period. Results: Among patients, 26.5% were diagnosed 2/3. proportions 2/3 among those who did not undergo hysterectomy 39.5% 24.7%, respectively. sensitivity cytology for only VaIN, concomitant cervical or vulvar...