A5055326025- Endometriosis Research and Treatment
- Cancer-related molecular mechanisms research
- Uterine Myomas and Treatments
- Insect and Pesticide Research
- Endometrial and Cervical Cancer Treatments
- Cholesterol and Lipid Metabolism
- Cervical Cancer and HPV Research
- Epigenetics and DNA Methylation
- Nanoparticle-Based Drug Delivery
- Radiomics and Machine Learning in Medical Imaging
- Insect and Arachnid Ecology and Behavior
- Cancer, Stress, Anesthesia, and Immune Response
- RNA Research and Splicing
- Glycosylation and Glycoproteins Research
- Genetic factors in colorectal cancer
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Urinary and Genital Oncology Studies
- Drug Transport and Resistance Mechanisms
- Nanoplatforms for cancer theranostics
- Lipid metabolism and biosynthesis
- Genomics and Chromatin Dynamics
- Insect symbiosis and bacterial influences
- Cancer-related gene regulation
- Nutrition, Genetics, and Disease
Shanghai Jiao Tong University
2012-2024
International Peace Maternity & Child Health Hospital
2013-2024
University of Oslo
2015-2024
Ruijin Hospital
2024
Shanghai Municipal People's Government
2020-2023
Shanghai Clinical Research Center
2022
Jinzhou Central Hospital
2020
Shanghai Public Health Clinical Center
2020
Jinzhou Medical University
2019
China Animal Disease Control Center
2019
Abstract Background Implementation of high-risk human papillomavirus (hrHPV) screening has greatly reduced the incidence and mortality cervical cancer. However, a triage strategy that is effective, noninvasive, independent from subjective interpretation pathologists urgently required to decrease unnecessary colposcopy referrals in hrHPV-positive women. Methods A total 3251 women aged 30–82 years (median = 41 years) International Peace Maternity Child Health Hospital were included training...
There are rapidly emerging efforts to explore tumor-associated macrophages (TAMs) as a tumor therapy target. Tumor cells express CD47, which can interact with the macrophages’ SIRP α transmitting “don’t eat me” signal macrophages. The expression of CD47 increases in various tumors evade immune attack. However, endometrial cancer (EC) and role CD47-SIRP TAMs mediate progression EC remain unclear. Our study shows that there increased dominantly consist M2 contribute EC. We confirm is highly...
Perineural invasion (PNI) has guiding significances for nerve preservation in cervical cancer, but there is no definite marker indicating PNI. Two cancer cell lines (HeLa and ME-180) showed significant abilities to migrate along neurites vitro vivo. Morphological observation revealed that Schwann cells (SC) arrived at the sites of before onset metastasis. We used high-throughput antibody array screen signals mediating interaction found high expression CCL2 dorsal root ganglion (DRG)....
Liver X receptor (LXR)α and LXRβ play key roles in hepatic de novo lipogenesis through their regulation of lipogenic genes, including sterol regulatory element-binding protein (SREBP)-1c carbohydrate responsive (ChREBP). LXRs activate gene transcription response to feeding, which is believed be mediated by insulin. We have previously shown that are targets for glucose-hexosamine-derived O-linked β-N-acetylglucosamine (O-GlcNAc) modification enhancing ability regulate SREBP-1c promoter...
Abstract Heterogeneity and drug resistance of tumor cells are the leading causes incurability poor survival for patients with recurrent breast cancer. In order to accurately deliver biological anticancer drugs different subtypes malignant omnidirectional targeted treatment cancer, a distinct design is demonstrated by embedding liposome‐based nanocomplexes containing pro‐apoptotic peptide survivin siRNA (LPR) into Herceptin/hyaluronic acid cross‐linked nanohydrogels (Herceptin‐HA) fabricate...
Perineural invasion (PNI) is a new approach of cervical cancer and metastasis, involving the cross-talk between tumor nerve. However, initiating signals cellular interaction mechanisms PNI remain largely elusive. The nerve-sparing radical hysterectomy (NSRH) proposed to improve postoperative quality life only applicable patients without PNI. Therefore, it important elucidate underlying PNI, suggest effective biomarkers predict before NSRH surgery. Here, we found that characteristic advanced...
// Mei-Ting Qiu 1, * , Qiong Fan Zhu 2, Suet-Ying Kwan 2 Limo Chen 3 Jin-Hong 4 Zuo-Lin Ying 5 Ye Zhou 1 Wei Gu Li-Hua Wang Wei-Wei Cheng Jianfang Zeng 6 Xiao-Ping Wan Samuel C. Mok Kwong-Kwok Wong Bao Departments of Obstetrics and Gynecology, International Peace Maternity & Child Health Hospital affiliated with the Shanghai Jiao Tong University School Medicine, Shanghai, China Department Gynecologic Oncology Reproductive The Texas MD Anderson Cancer Center, Houston, TX, USA Thoracic/Head...
The aberrant expression of miR107‑5p is closely related to the development several types human cancers. However, role miR‑107‑5p in endometrial carcinoma (EC) has not been fully confirmed. In present study, we aimed explore function EC carcinogenesis. samples and normal tissues were obtained by laser capture microdissection. It was determined that significantly higher than endometrium, advanced FIGO stages, lymph node metastasis myometrial invasion patients. Blocking inhibited cell...
Cervical cancer is the most common gynecological in women worldwide. Human papillomavirus (HPV) required but not sufficient for developing cervical cancer. HPV E6 and E7 proteins are able to directly interact with certain nuclear receptors; however, whether steroid hormone receptors mediate carcinogenesis completely understood. The present study demonstrated via immunohistochemistry that estrogen receptor α (ERα) androgen (AR) expression were decreased a sequential manner from healthy...
Breast cancer is a highly aggressive malignancy and always has poor prognosis. The current therapeutic strategies including surgery, chemotherapy radiotherapy benefit little for patients survival. Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can induce apoptosis in wide range of cells, such as breast cancer, it also cytotoxicity to normal cells. To improve the selectivity TRAIL expression we inserted miRNA response elements (MREs) let-7 miR-122 into...
Abstract Flavopiridol (FP) is a pan-cyclin dependent kinase inhibitor, which shows strong efficacy in inducing cancer cell apoptosis. Although FP potent against most cells vitro , unfortunately it proved less efficacious clinical trials various aggressive cancers. To date, the molecular mechanisms of resistance are mostly unknown. Here, we report that small fraction human prostate DU145 can survive long-term treatment and emerge as FP-resistant (DU145 ). These show accumulated mitochondrial...
Many mammalian genes exhibit circadian expression patterns concordant with periodic binding of transcription factors, chromatin modifications, and chromosomal interactions. Here we investigate whether periodically associates nuclear lamins. Entrainment the clock is accompanied, in mouse liver, by a net gain lamin B1-chromatin interactions genome-wide, after which majority lamina-associated domains (LADs) are conserved during cycle. By tailoring bioinformatics pipeline designed to identify...
Oncogenic high-risk human papillomavirus (HR-HPV) infection causes a majority of cases cervical cancer and pre-cancerous lesions. However, the mechanisms underlying direct evolution from HPV-16/18-infected epithelium to intraepithelial neoplasia (CIN) III, which can progress cancer, remain poorly identified. Here, we performed RNA-seq after laser capture microdissection, found that APOBEC3B was highly expressed in specimens compared with CIN III HPV-16/18 infection. Furthermore,...
Abstract Background Rather low vaccination rates for Human papillomavirus (HPV) and pre-existing cervical cancer patients with limited therapeutic strategies ask more precise prognostic model development. On the other side, clinical significance of circadian clock signatures in lacks investigation. Methods Subtypes classification based upon eight core genes were implemented TCGA-CESC through k-means clustering methods. Afterwards, KEGG, GO GSEA analysis conducted differentially expressed...
Liver X receptors (LXRα/β) and carbohydrate response element-binding proteins (ChREBPα/β) are key players in the transcriptional control of hepatic de novo lipogenesis. LXRα/β double knockout (LXRα−/−/β−/−) mice have reduced feeding-induced nuclear O-linked N-acetylglucosamine (O-GlcNAc) signaling, ChREBPα activity, lipogenic gene expression livers, suggesting important roles for LXRs linking glucose utilization to lipid synthesis. However, role fructose-induced ChREBP activation lipogenesis...
The LMNA gene encodes lamins A and C with key roles in nuclear structure, signaling, regulation, genome integrity. Mutations cause over 12 diseases (‘laminopathies’). Lamins are identical for their first 566 residues. However, they form separate filaments vivo, apparently distinct roles. We report that lamin is β-O-linked N-acetylglucosamine-(O-GlcNAc)-modified human hepatoma (Huh7) cells mouse liver. In vitro assays purified O-GlcNAc transferase (OGT) enzyme showed robust O-GlcNAcylation of...
Abstract Monocytes play multiple roles in the immune system, and are active both acute chronic diseases. Patients exposed to bacterial infections depend on monocytes defense reactions, but excessive reactions may also cause morbidity through systemic inflammatory responses. Few studies have addressed importance of proteoglycans, particular, hematopoietic serglycin, such monocyte reactions. Adherent primary were cultured absence presence LPS. Media analyzed by ELISA for detection serglycin....
Background Deformed wing virus (DWV) is one of many viruses that infect honeybees and has been extensively studied because its close association with honeybee colony collapse induced by Varroa destructor . However, genotypes, sequence characteristics, genetic variations DWV remain unknown in China. Methods Two strains were isolated from Jinzhou Qinhuangdao cities China, named China1-2017 (accession number: MF770715 ) China2-2018 MH165180 ), respectively, their complete genome sequences...
Epidermal growth factor receptor pathway substrate 8 (Eps8) has been identified as a novel for epidermal (EGFR) kinase and is involved in EGFR‑mediated signaling pathways correlated with tumorigenesis, proliferation metastasis various cancer types. However, the precise role of Eps8 cervical remains to be elucidated. Immunohistochemistry revealed that was significantly increased specimens compared squamous intraepithelial lesion normal tissues. Additionally, it expression not only...